4-benzo[b]thiophen-2-ylmethyl-5-oxo-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

Base Information

• Chemical Name: 4-benzo[b]thiophen-2-ylmethyl-5-oxo-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester
• CAS No.: 1025971-36-1
• Molecular Formula: C₂₆H₂₇NO₅S
• Molecular Weight: 465.57

Synonyms:4-benzo[b]thiophen-2-ylmethyl-5-oxo-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

Chemical Property of 4-benzo[b]thiophen-2-ylmethyl-5-oxo-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-benzo[b]thiophen-2-ylmethyl-5-oxo-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

There total 4 articles about 4-benzo[b]thiophen-2-ylmethyl-5-oxo-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromomethylbenzo[b]thiophene (10133-20-7) + 2-benzyl 1-(tert-butyl) (R)-5-oxopyrrolidine-1,2-dicarboxylate (400626-71-3) → 4-benzo[b]thiophen-2-ylmethyl-5-oxo-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester (1025971-36-1)

Guidance literature:

2-benzyl 1-(tert-butyl) (R)-5-oxopyrrolidine-1,2-dicarboxylate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

2-bromomethylbenzo[b]thiophene; In tetrahydrofuran; at -78 ℃; for 2h;

DOI:10.1021/jm020901d

Reference yield:

benzothiophene-2-carboxaldehyde (3541-37-5) → 4-benzo[b]thiophen-2-ylmethyl-5-oxo-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester (1025971-36-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: DIBAL-H / tetrahydrofuran; hexane / 1 h / -78 °C

2.1: aq. HBr; H₂SO₄ / CH₂Cl₂ / 1.5 h

3.1: lithium hexamethyldisilazide / tetrahydrofuran / 1 h / -78 °C

3.2: tetrahydrofuran / 2 h / -78 °C

With sulfuric acid; hydrogen bromide; diisobutylaluminium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/jm020901d

Reference yield:

benzothiophene-2-methanol (17890-56-1) → 4-benzo[b]thiophen-2-ylmethyl-5-oxo-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester (1025971-36-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aq. HBr; H₂SO₄ / CH₂Cl₂ / 1.5 h

2.1: lithium hexamethyldisilazide / tetrahydrofuran / 1 h / -78 °C

2.2: tetrahydrofuran / 2 h / -78 °C

With sulfuric acid; hydrogen bromide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm020901d

upstream raw materials:

2-bromomethylbenzo[b]thiophene

2-benzyl 1-(tert-butyl) (R)-5-oxopyrrolidine-1,2-dicarboxylate

benzothiophene-2-carboxaldehyde

benzothiophene-2-methanol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1025971-36-1 4-benzo[b]thiophen-2-ylmethyl-5-oxo-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send