[((S)-2-Acetoxy-6-benzyloxycarbonylamino-hexanoyl)-(4-methoxy-phenyl)-amino]-acetic acid ethyl ester

Base Information

• Chemical Name: [((S)-2-Acetoxy-6-benzyloxycarbonylamino-hexanoyl)-(4-methoxy-phenyl)-amino]-acetic acid ethyl ester
• CAS No.: 126111-19-1
• Molecular Formula: C₂₇H₃₄N₂O₈
• Molecular Weight: 514.576
• Mol file: 126111-19-1.mol

Synonyms:[((S)-2-Acetoxy-6-benzyloxycarbonylamino-hexanoyl)-(4-methoxy-phenyl)-amino]-acetic acid ethyl ester

Chemical Property of [((S)-2-Acetoxy-6-benzyloxycarbonylamino-hexanoyl)-(4-methoxy-phenyl)-amino]-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [((S)-2-Acetoxy-6-benzyloxycarbonylamino-hexanoyl)-(4-methoxy-phenyl)-amino]-acetic acid ethyl ester

There total 3 articles about [((S)-2-Acetoxy-6-benzyloxycarbonylamino-hexanoyl)-(4-methoxy-phenyl)-amino]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-6-[[(Phenylmethoxy)carbonyl]amino]-2-hydroxyhexanoic acid (59221-35-1) → [((S)-2-Acetoxy-6-benzyloxycarbonylamino-hexanoyl)-(4-methoxy-phenyl)-amino]-acetic acid ethyl ester (126111-19-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / triethylamine / tetrahydrofuran / 2 h / 0 °C

2: Et₃N, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / 0 °C

3: 2.) pyridine / tetrahydrofuran / 1.) room temp., 16 h, 2.) room temp., 24 h

With pyridine; dmap; triethylamine; In tetrahydrofuran;

DOI:10.1021/jm00167a028

Reference yield:

(S)-2-(acetyloxy)-6-<<(phenylmethoxy)carbonyl>amino>hexanoic acid (126111-17-9) → [((S)-2-Acetoxy-6-benzyloxycarbonylamino-hexanoyl)-(4-methoxy-phenyl)-amino]-acetic acid ethyl ester (126111-19-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / 0 °C

2: 2.) pyridine / tetrahydrofuran / 1.) room temp., 16 h, 2.) room temp., 24 h

With pyridine; dmap; triethylamine; In tetrahydrofuran;

DOI:10.1021/jm00167a028

Reference yield:

N-(4-methoxy)phenylglycine ethyl ester (50845-77-7) + C21H29NO7 → [((S)-2-Acetoxy-6-benzyloxycarbonylamino-hexanoyl)-(4-methoxy-phenyl)-amino]-acetic acid ethyl ester (126111-19-1)

Guidance literature:

With pyridine; In tetrahydrofuran; Yield given; 1.) room temp., 16 h, 2.) room temp., 24 h;

DOI:10.1021/jm00167a028

upstream raw materials:

N-(4-methoxy)phenylglycine ethyl ester

(S)-6-[[(Phenylmethoxy)carbonyl]amino]-2-hydroxyhexanoic acid

(S)-2-(acetyloxy)-6-<<(phenylmethoxy)carbonyl>amino>hexanoic acid

Downstream raw materials:

[{(S)-6-Benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-(4-methoxy-phenyl)-amino]-acetic acid benzhydryl ester

[((S)-6-Benzyloxycarbonylamino-2-hydroxy-hexanoyl)-(4-methoxy-phenyl)-amino]-acetic acid benzhydryl ester

[{(S)-6-Amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-(4-methoxy-phenyl)-amino]-acetic acid