126111-17-9

Upstream product

• 59221-35-1 (S)-6-[[(Phenylmethoxy)carbonyl]amino]-2-hydroxyhexanoic acid 
• 75-36-5 acetyl chloride 
• 1155-64-2 N₆-[(benzyloxy)carbonyl]-L-lysine 

Downstream Products

• 126110-73-4 [{(S)-6-Benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-(3,4-dimethoxy-phenyl)-amino]-acetic acid benzhydryl ester 
• 126110-74-5 (Benzo[1,3]dioxol-5-yl-{(S)-6-benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-amino)-acetic acid benzhydryl ester 
• 126110-72-3 [{(S)-6-Benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-(4-methoxy-phenyl)-amino]-acetic acid benzhydryl ester 
• 126110-71-2 ({(S)-6-Benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-phenyl-amino)-acetic acid benzhydryl ester 
• 126110-96-1 (S)-<<2-hydroxy-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>(2,3-dimethoxyphenyl)amino>acetic acid diphenylmethyl ester 
• 126110-97-2 [Benzo[1,3]dioxol-5-yl-((S)-6-benzyloxycarbonylamino-2-hydroxy-hexanoyl)-amino]-acetic acid benzhydryl ester 
• 126110-95-0 [((S)-6-Benzyloxycarbonylamino-2-hydroxy-hexanoyl)-(4-methoxy-phenyl)-amino]-acetic acid benzhydryl ester 
• 126110-94-9 [((S)-6-Benzyloxycarbonylamino-2-hydroxy-hexanoyl)-phenyl-amino]-acetic acid benzhydryl ester 
• 126111-21-5 [((S)-2-Acetoxy-6-benzyloxycarbonylamino-hexanoyl)-benzo[1,3]dioxol-5-yl-amino]-acetic acid methyl ester 
• 126111-20-4 (S)-<<2-(acetyloxy)-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>(3,4-dimethoxyphenyl)amino>acetic acid methyl ester 
• 126132-90-9 [{(S)-6-Amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-(3,4-dimethoxy-phenyl)-amino]-acetic acid 

Relevant academic research and scientific papers

Conformational studies on peptides of α-aminoxy acids with functionalized side-chains

Peptides of homochiral α- aminoxy acids of nonpolar side chains can form a 1.88-helix. In this paper, we report the conformational studies of α- aminoxy peptides 1-3, which have functionalized side chains, in both non- polar and polar solvents.

(Phosphinyloxy)acid amino acid inhibitors of angiotensin converting enzyme. 2. Terminal amino acid analogues of (S)-1-[6-Amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]- L-proline

Analogues of (S)-1-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]- L-proline (1, SQ 29,852) in which the terminal proline residue has been replaced by a variety of substituted and heteroatom-substituted prolines, N-arylglycines, N-cycloalkylglycines, and bicyclic amino acids have been synthesized and evaluated as inhibitors of angiotensin converting enzyme in vitro an in vivo. In general, the addition of lipophilic substituents to the 4-position of proline of the parent phosphate 1 resulted in substantial increases in vitro activity. The largest improvements were observed in the case of cis-benzyl (36-fold) and dithioketal (24-fold) analogues 2r and 2x, respectively. These enhancements of in vitro activity were accompanied by modest increases (2-3.5-fold) in in vivo (iv) activity. Among the various terminal amino acid replacements examined in this study, the indoline-based analogue 2i was by far the most potent compound on iv administration in the normotensive rat.