(R)-N-methoxy-N-methyl-2-(4-trifluoromethylphenyl)-4,5-dihydrothiazole-4-carboxamide

Base Information

• Chemical Name: (R)-N-methoxy-N-methyl-2-(4-trifluoromethylphenyl)-4,5-dihydrothiazole-4-carboxamide
• CAS No.: 1135797-78-2
• Molecular Formula: C₁₃H₁₃F₃N₂O₂S
• Molecular Weight: 318.32

Synonyms:(R)-N-methoxy-N-methyl-2-(4-trifluoromethylphenyl)-4,5-dihydrothiazole-4-carboxamide

Chemical Property of (R)-N-methoxy-N-methyl-2-(4-trifluoromethylphenyl)-4,5-dihydrothiazole-4-carboxamide

Chemical Property:

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Technology Process of (R)-N-methoxy-N-methyl-2-(4-trifluoromethylphenyl)-4,5-dihydrothiazole-4-carboxamide

There total 2 articles about (R)-N-methoxy-N-methyl-2-(4-trifluoromethylphenyl)-4,5-dihydrothiazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

(R)-2-(4-trifluoromethylphenyl)-4,5-dihydrothiazole-4-carboxylic acid (1196463-65-6) + N,0-dimethylhydroxylamine (1117-97-1) → (R)-N-methoxy-N-methyl-2-(4-trifluoromethylphenyl)-4,5-dihydrothiazole-4-carboxamide (1135797-78-2)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

DOI:10.1021/jm801449a

Reference yield: 62.0%

→ (R)-N-methoxy-N-methyl-2-(4-trifluoromethylphenyl)-4,5-dihydrothiazole-4-carboxamide (1135797-78-2)

Guidance literature:

Reference yield:

(R)-N-methoxy-N-methyl-2-(4-trifluoromethylphenyl)-4,5-dihydrothiazole-4-carboxamide (1135797-78-2) → C13H11F3N2O2S (1202516-98-0)

Guidance literature:

With Bromotrichloromethane; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jm801449a

upstream raw materials:

(R)-2-(4-trifluoromethylphenyl)-4,5-dihydrothiazole-4-carboxylic acid

N,0-dimethylhydroxylamine

Downstream raw materials:

C₁₃H₁₁F₃N₂O₂S

(2-(4-(trifluoromethyl)phenyl)thiazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

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