benzhydryl 7β-t-butoxycarbonylamino-3-[(Z)-2-(imidazo[1,2-b]pyridazine-6-yl)thiovinyl]-3-cephem-4-carboxylate

Base Information

Chemical Name:benzhydryl 7β-t-butoxycarbonylamino-3-[(Z)-2-(imidazo[1,2-b]pyridazine-6-yl)thiovinyl]-3-cephem-4-carboxylate
CAS No.:181784-83-8
Molecular Formula:C₃₃H₃₁N₅O₅S₂
Molecular Weight:641.772
Hs Code.:

Synonyms:benzhydryl 7β-t-butoxycarbonylamino-3-[(Z)-2-(imidazo[1,2-b]pyridazine-6-yl)thiovinyl]-3-cephem-4-carboxylate

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Chemical Property of benzhydryl 7β-t-butoxycarbonylamino-3-[(Z)-2-(imidazo[1,2-b]pyridazine-6-yl)thiovinyl]-3-cephem-4-carboxylate

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Technology Process of benzhydryl 7β-t-butoxycarbonylamino-3-[(Z)-2-(imidazo[1,2-b]pyridazine-6-yl)thiovinyl]-3-cephem-4-carboxylate

There total 3 articles about benzhydryl 7β-t-butoxycarbonylamino-3-[(Z)-2-(imidazo[1,2-b]pyridazine-6-yl)thiovinyl]-3-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 181784-82-7
benzhydryl 7β-t-butoxycarbonylamino-3-[(Z)-2-(imidazo[1,2-b]pyridazine-6-yl)thiovinyl]-1-oxide-3-cephem-4-carboxylate

: 181784-83-8
benzhydryl 7β-t-butoxycarbonylamino-3-[(Z)-2-(imidazo[1,2-b]pyridazine-6-yl)thiovinyl]-3-cephem-4-carboxylate

Guidance literature:: With phosphorus trichloride; In dichloromethane; N,N-dimethyl acetamide; at -10 ℃; for 1h;
DOI:10.7164/antibiotics.54.257

Reference yield:

: 6775-78-6
6-chloroimidazo[1,2-b]pyridazine

: 181784-83-8
benzhydryl 7β-t-butoxycarbonylamino-3-[(Z)-2-(imidazo[1,2-b]pyridazine-6-yl)thiovinyl]-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / NaOMe / methanol / 3 h / 80 °C

2: 82 percent / dimethylformamide / 1 h / 20 °C

3: 82 percent / PCl₃ / CH₂Cl₂; N,N-dimethyl-acetamide / 1 h / -10 °C

With sodium methylate; phosphorus trichloride; In methanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.7164/antibiotics.54.257

Reference yield:

: sodium imidazo[1,2-b]pyridazine-6-thiolate

: 181784-83-8
benzhydryl 7β-t-butoxycarbonylamino-3-[(Z)-2-(imidazo[1,2-b]pyridazine-6-yl)thiovinyl]-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / dimethylformamide / 1 h / 20 °C

2: 82 percent / PCl₃ / CH₂Cl₂; N,N-dimethyl-acetamide / 1 h / -10 °C

With phosphorus trichloride; In dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.7164/antibiotics.54.257