(+)-(1R,2S,3S)-2-amino-7-<2,3-bis<(benzyloxy)methyl>cyclobutyl>pyrrolo<2,3-d>-pyrimidin-4(3H)-one

Base Information

Chemical Name:(+)-(1R,2S,3S)-2-amino-7-<2,3-bis<(benzyloxy)methyl>cyclobutyl>pyrrolo<2,3-d>-pyrimidin-4(3H)-one
CAS No.:142343-78-0
Molecular Formula:C₂₆H₂₈N₄O₃
Molecular Weight:444.533
Hs Code.:

Synonyms:(+)-(1R,2S,3S)-2-amino-7-<2,3-bis<(benzyloxy)methyl>cyclobutyl>pyrrolo<2,3-d>-pyrimidin-4(3H)-one

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Chemical Property of (+)-(1R,2S,3S)-2-amino-7-<2,3-bis<(benzyloxy)methyl>cyclobutyl>pyrrolo<2,3-d>-pyrimidin-4(3H)-one

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Technology Process of (+)-(1R,2S,3S)-2-amino-7-<2,3-bis<(benzyloxy)methyl>cyclobutyl>pyrrolo<2,3-d>-pyrimidin-4(3H)-one

There total 12 articles about (+)-(1R,2S,3S)-2-amino-7-<2,3-bis<(benzyloxy)methyl>cyclobutyl>pyrrolo<2,3-d>-pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 142343-77-9
(+)-(1R,2S,3S)-2-amino-7-<2,3-bis<(benzyloxy)methyl>cyclobutyl>-4-chloropyrrolo<2,3-d>-pyrimidine

: 142343-78-0
(+)-(1R,2S,3S)-2-amino-7-<2,3-bis<(benzyloxy)methyl>cyclobutyl>pyrrolo<2,3-d>-pyrimidin-4(3H)-one

Guidance literature:: With sodium hydroxide; In methanol;
DOI:10.1016/S0040-4039(00)74181-5

Reference yield:

: 100-39-0
benzyl bromide

: 142343-78-0
(+)-(1R,2S,3S)-2-amino-7-<2,3-bis<(benzyloxy)methyl>cyclobutyl>pyrrolo<2,3-d>-pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 11 steps

1: 1) NaH / 1) DMF

2: 100 percent / 0.5percent H₂SO₄ / acetonitrile

3: 81 percent / LS-Selectride / tetrahydrofuran / -78 °C

4: 48 percent / pyridine

5: 100 percent / KOH / methanol

6: 90 percent / pyridine

7: NaN₃ / dimethylformamide / 100 °C

8: BH₃*THF / tetrahydrofuran

9: Et₃N / butan-1-ol / 100 °C

10: 63 percent / 2 N HCl

11: 78 percent / 5percent aq. NaOH / methanol

With pyridine; hydrogenchloride; potassium hydroxide; sodium hydroxide; sodium azide; borane-THF; sulfuric acid; sodium hydride; lithium tri-sec-butyl(hydrido)borate; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile; butan-1-ol;
DOI:10.1016/S0040-4039(00)74181-5

Reference yield:

: 126261-70-9,127696-11-1,132294-14-5,132294-22-5
(+/-)-trans-1,2-bis-(3,3-diethoxycyclobutylen)methanol

: 142343-78-0
(+)-(1R,2S,3S)-2-amino-7-<2,3-bis<(benzyloxy)methyl>cyclobutyl>pyrrolo<2,3-d>-pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 11 steps

1: 1) NaH / 1) DMF

2: 100 percent / 0.5percent H₂SO₄ / acetonitrile

3: 81 percent / LS-Selectride / tetrahydrofuran / -78 °C

4: 48 percent / pyridine

5: 100 percent / KOH / methanol

6: 90 percent / pyridine

7: NaN₃ / dimethylformamide / 100 °C

8: BH₃*THF / tetrahydrofuran

9: Et₃N / butan-1-ol / 100 °C

10: 63 percent / 2 N HCl

11: 78 percent / 5percent aq. NaOH / methanol

With pyridine; hydrogenchloride; potassium hydroxide; sodium hydroxide; sodium azide; borane-THF; sulfuric acid; sodium hydride; lithium tri-sec-butyl(hydrido)borate; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile; butan-1-ol;
DOI:10.1016/S0040-4039(00)74181-5