Ethyl 2-<(trifluoroacetyl)amino>-3-(3-hydroxyphenyl)-4-fluoro-3-butenoate

Base Information

Chemical Name:Ethyl 2-<(trifluoroacetyl)amino>-3-(3-hydroxyphenyl)-4-fluoro-3-butenoate
CAS No.:160848-41-9
Molecular Formula:C₁₄H₁₃F₄NO₄
Molecular Weight:335.255
Hs Code.:

Synonyms:Ethyl 2-<(trifluoroacetyl)amino>-3-(3-hydroxyphenyl)-4-fluoro-3-butenoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 2-<(trifluoroacetyl)amino>-3-(3-hydroxyphenyl)-4-fluoro-3-butenoate

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Technology Process of Ethyl 2-<(trifluoroacetyl)amino>-3-(3-hydroxyphenyl)-4-fluoro-3-butenoate

There total 2 articles about Ethyl 2-<(trifluoroacetyl)amino>-3-(3-hydroxyphenyl)-4-fluoro-3-butenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 823809-62-7
(E)-2-Amino-4-fluoro-3-(3-hydroxy-phenyl)-but-3-enoic acid ethyl ester

: 407-25-0
trifluoroacetic anhydride

: 160848-41-9
Ethyl 2-<(trifluoroacetyl)amino>-3-(3-hydroxyphenyl)-4-fluoro-3-butenoate

Guidance literature:: 1.) -78 deg C to r.t., 2.) r.t., 5 h;
DOI:10.1021/jo00106a038

Reference yield:

: 99630-95-2
MDL 72394

: 160848-41-9
Ethyl 2-<(trifluoroacetyl)amino>-3-(3-hydroxyphenyl)-4-fluoro-3-butenoate

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / HCl / 5 h / Heating

2: 77 percent / 1.) -78 deg C to r.t., 2.) r.t., 5 h

With hydrogenchloride;
DOI:10.1021/jo00106a038