2-(4-dimethylaminosulfonylamino-3-fluoro-phenyl)-propionic acid ethylester

Base Information

Chemical Name:2-(4-dimethylaminosulfonylamino-3-fluoro-phenyl)-propionic acid ethylester
CAS No.:935520-77-7
Molecular Formula:C₁₃H₁₉FN₂O₄S
Molecular Weight:318.369
Hs Code.:

Synonyms:2-(4-dimethylaminosulfonylamino-3-fluoro-phenyl)-propionic acid ethylester

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Chemical Property of 2-(4-dimethylaminosulfonylamino-3-fluoro-phenyl)-propionic acid ethylester

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Technology Process of 2-(4-dimethylaminosulfonylamino-3-fluoro-phenyl)-propionic acid ethylester

There total 1 articles about 2-(4-dimethylaminosulfonylamino-3-fluoro-phenyl)-propionic acid ethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 95037-98-2
ethyl 2-(4-amino-3-fluorophenyl)propionate

: 13360-57-1
dimethylamino sulfonyl chloride

: 935520-77-7
2-(4-dimethylaminosulfonylamino-3-fluoro-phenyl)-propionic acid ethylester

Guidance literature:: In pyridine; at 0 - 20 ℃; for 3.1667h;

Reference yield:

: 935520-77-7
2-(4-dimethylaminosulfonylamino-3-fluoro-phenyl)-propionic acid ethylester

: 935520-78-8
2-(4-dimethylaminosulfonylamino-3-fluoro-phenyl)-propionic acid

Guidance literature:: 2-(4-dimethylaminosulfonylamino-3-fluoro-phenyl)-propionic acid ethylester; With lithium hydroxide; water; In tetrahydrofuran; at 40 ℃; for 4h;

With hydrogenchloride; In dichloromethane; water;

Reference yield:

: 935520-77-7
2-(4-dimethylaminosulfonylamino-3-fluoro-phenyl)-propionic acid ethylester

: C₂₄H₃₁F₄N₅O₃S

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / water; tetrahydrofuran / 20 °C

2: 1,2-dichloro-ethane; benzotriazol-1-ol; triethylamine / acetonitrile

With lithium hydroxide monohydrate; benzotriazol-1-ol; 1,2-dichloro-ethane; triethylamine; In tetrahydrofuran; water; acetonitrile;
DOI:10.1016/j.bmcl.2018.05.043