C₆₄H₈₃N₅O₂₄

Base Information

• Chemical Name: C₆₄H₈₃N₅O₂₄
• CAS No.: 217180-13-7
• Molecular Formula: C₆₄H₈₃N₅O₂₄
• Molecular Weight: 1306.38
• Mol file: 217180-13-7.mol

Synonyms:C₆₄H₈₃N₅O₂₄

Chemical Property of C₆₄H₈₃N₅O₂₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₄H₈₃N₅O₂₄

There total 7 articles about C₆₄H₈₃N₅O₂₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

benzyl (2S,3S,4R)-4-amino-3-hydroxy-2-methylvalerate hydrochloride + C51H66N4O22 (217180-11-5) → C64H83N5O24 (217180-13-7)

Guidance literature:

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 25 ℃; for 5h;

DOI:10.1021/ja9819458

Reference yield:

Acetic acid (2S,3R,4S,5S,6R)-3,4-bis-benzyloxy-6-chloro-5-((2R,3S,4S,5R,6R)-3,5-diacetoxy-6-acetoxymethyl-4-carbamoyloxy-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-ylmethyl ester (217180-01-3) → C64H83N5O24 (217180-13-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 11 percent / AgOTf, 1,1,3,3-tetramethylurea / 1,2-dichloro-ethane / 22 h / 48 °C

2: 64 percent / pyridine / 1 h / 25 °C

3: 54 percent / H₂ / 10percent Pd/C / ethanol / 20 h / 25 °C / 760 Torr

4: 70 percent / N,N-diisopropylethylamine, 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 5 h / 25 °C

With pyridine; hydrogen; silver trifluoromethanesulfonate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; tetramethylurea; palladium on activated charcoal; In ethanol; dichloromethane; 1,2-dichloro-ethane;

DOI:10.1021/ja9819458

Reference yield:

L-erythro-Nα,Nim-di-tert-butoxycarbonyl-β-hydroxyhistidine benzyl ester (83044-04-6) → C64H83N5O24 (217180-13-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 11 percent / AgOTf, 1,1,3,3-tetramethylurea / 1,2-dichloro-ethane / 22 h / 48 °C

2: 64 percent / pyridine / 1 h / 25 °C

3: 54 percent / H₂ / 10percent Pd/C / ethanol / 20 h / 25 °C / 760 Torr

4: 70 percent / N,N-diisopropylethylamine, 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 5 h / 25 °C

With pyridine; hydrogen; silver trifluoromethanesulfonate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; tetramethylurea; palladium on activated charcoal; In ethanol; dichloromethane; 1,2-dichloro-ethane;

DOI:10.1021/ja9819458

upstream raw materials:

C₅₁H₆₆N₄O₂₂

N^α,N^im-bis(tert-butoxycarbonyl)-erythro-β-hydroxy-L-histidine

L-erythro-N^α,N^im-di-tert-butoxycarbonyl-β-hydroxyhistidine benzyl ester

1,6-di-O-acetyl-3,4-di-O-benzyl-2-O-(2,4,6-tri-O-acetyl-3-O-carbamoyl-α-D-mannopyranosyl)-β-L-gulopyranose