1-{4-[(acetylamino)methyl]benzyl}-N-cycloheptyl-2-(2-naphthylsulfonyl)-1-hydrazinecarboxamide

Base Information

Chemical Name:1-{4-[(acetylamino)methyl]benzyl}-N-cycloheptyl-2-(2-naphthylsulfonyl)-1-hydrazinecarboxamide
CAS No.:845725-39-5
Molecular Formula:C₂₈H₃₄N₄O₄S
Molecular Weight:522.668
Hs Code.:

Synonyms:1-{4-[(acetylamino)methyl]benzyl}-N-cycloheptyl-2-(2-naphthylsulfonyl)-1-hydrazinecarboxamide

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Chemical Property of 1-{4-[(acetylamino)methyl]benzyl}-N-cycloheptyl-2-(2-naphthylsulfonyl)-1-hydrazinecarboxamide

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Technology Process of 1-{4-[(acetylamino)methyl]benzyl}-N-cycloheptyl-2-(2-naphthylsulfonyl)-1-hydrazinecarboxamide

There total 9 articles about 1-{4-[(acetylamino)methyl]benzyl}-N-cycloheptyl-2-(2-naphthylsulfonyl)-1-hydrazinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 93-11-8
2-Naphthalenesulfonyl chloride

: 2-{4-[(acetylamino)methyl]benzyl}-2-[(cycloheptylamino)carbonyl]hydrazinium chloride

: 845725-39-5
1-{4-[(acetylamino)methyl]benzyl}-N-cycloheptyl-2-(2-naphthylsulfonyl)-1-hydrazinecarboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 72h;

Reference yield:

: 66739-89-7
4-(1,3-dioxolan-2-yl)benzonitrile

: 845725-39-5
1-{4-[(acetylamino)methyl]benzyl}-N-cycloheptyl-2-(2-naphthylsulfonyl)-1-hydrazinecarboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: LiAlH₄ / tetrahydrofuran

2.1: 98 percent / ethanol / 5 h / Heating

3.1: 98 percent / H₂ / 10 percent Pd/C / methanol

4.1: diisopropylethylamine / CH₂Cl₂ / 0.5 h / 20 °C

4.2: 94 percent / CH₂Cl₂ / 1 h / 20 °C

5.1: 90 percent / HCl / ethyl acetate / 0.5 h

6.1: 76 percent / diisopropylethylamine / CH₂Cl₂ / 72 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate;

Reference yield:

: 105-07-7
4-cyanobenzaldehyde

: 845725-39-5
1-{4-[(acetylamino)methyl]benzyl}-N-cycloheptyl-2-(2-naphthylsulfonyl)-1-hydrazinecarboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: p-TsOH / toluene

2.1: LiAlH₄ / tetrahydrofuran

3.1: 98 percent / ethanol / 5 h / Heating

4.1: 98 percent / H₂ / 10 percent Pd/C / methanol

5.1: diisopropylethylamine / CH₂Cl₂ / 0.5 h / 20 °C

5.2: 94 percent / CH₂Cl₂ / 1 h / 20 °C

6.1: 90 percent / HCl / ethyl acetate / 0.5 h

7.1: 76 percent / diisopropylethylamine / CH₂Cl₂ / 72 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; toluene;