[4-(1,3-Dioxolan-2-yl)phenyl]methanamine

Base Information

• Chemical Name: [4-(1,3-Dioxolan-2-yl)phenyl]methanamine
• CAS No.: 104566-44-1
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.219
• European Community (EC) Number: 872-877-5
• Nikkaji Number: J1.127.976G
• Mol file: 104566-44-1.mol

Synonyms:104566-44-1;[4-(1,3-dioxolan-2-yl)phenyl]methanamine;(4-(1,3-DIOXOLAN-2-YL)PHENYL)METHANAMINE;4-(1,3-dioxacyclopent-2-yl)benzylamine;SCHEMBL1680897;NUKQIICQHKOVHB-UHFFFAOYSA-N;4-[1,3]Dioxolan-2-yl-benzylamine;AB9170;MFCD06213279;4-([1,3]dioxolane-2-yl)benzylamine;4-[1,3]-Dioxolan-2-yl-benzylamine;AKOS006239252;AS-44949;4-(1,3-Dioxolane-2-yl)benzenemethanamine;EN300-52282;1-[4-(1,3-DIOXOLAN-2-YL)PHENYL]METHANAMINE

Chemical Property of [4-(1,3-Dioxolan-2-yl)phenyl]methanamine

Chemical Property:

• Melting Point: 108 °C
• PSA: 44.48000
• LogP: 1.89100
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 179.094628657
• Heavy Atom Count: 13
• Complexity: 149

Purity/Quality:

[4-(1,3-Dioxolan-2-yl)phenyl]methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(O1)C2=CC=C(C=C2)CN

Technology Process of [4-(1,3-Dioxolan-2-yl)phenyl]methanamine

There total 8 articles about [4-(1,3-Dioxolan-2-yl)phenyl]methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-(1,3-dioxolan-2-yl)benzonitrile (66739-89-7) → 4-(1,3-dioxacyclopent-2-yl)benzylamine (104566-44-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; Reflux;

DOI:10.1002/ejoc.200800363

Reference yield: 87.0%

p-toluenesulfonic acid monohydrate (6192-52-5) + 4-cyanobenzaldehyde (105-07-7) → 4-(1,3-dioxacyclopent-2-yl)benzylamine (104566-44-1)

Guidance literature:

With magnesium sulfate; In tetrahydrofuran; water; ethylene glycol; ethyl acetate; toluene;

Reference yield: 78.0%

N-(4-(1,3-dioxolan-2-yl)benzyl)acetamide (738615-92-4) → 4-(1,3-dioxacyclopent-2-yl)benzylamine (104566-44-1)

Guidance literature:

With ammonium iodide; hydrazine hydrate; at 60 ℃; for 36h; Inert atmosphere; Sealed tube;

DOI:10.1039/c4cc02014f

upstream raw materials:

4-(1,3-dioxolan-2-yl)benzonitrile

4-cyanobenzaldehyde

ethylene glycol

p-toluenesulfonic acid monohydrate

Downstream raw materials:

3-(cholesteryloxy)-N-(4-(1,3-dioxolan-2-yl)benzyl)propanamide

N-[4-(1,3-dioxolane-2-yl)benzyl]perylene-3,4-dicarboximide

N-(4-formylbenzyl)perylene-3,4-dicarboximide

N-(4-phenyliminomethylbenzyl)perylene-3,4-dicarboximide