trans-3-{[(4-(Boc-methyl-amino)-cyclohexyl)-(3-chloro-benzo[b]thiophene-2-carbonyl)-amino]-methyl}-4-ethoxy-benzeneboronic acid

Base Information

Chemical Name:trans-3-{[(4-(Boc-methyl-amino)-cyclohexyl)-(3-chloro-benzo[b]thiophene-2-carbonyl)-amino]-methyl}-4-ethoxy-benzeneboronic acid
CAS No.:945997-08-0
Molecular Formula:C₃₀H₃₈BClN₂O₆S
Molecular Weight:600.972
Hs Code.:

Synonyms:trans-3-{[(4-(Boc-methyl-amino)-cyclohexyl)-(3-chloro-benzo[b]thiophene-2-carbonyl)-amino]-methyl}-4-ethoxy-benzeneboronic acid

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Chemical Property of trans-3-{[(4-(Boc-methyl-amino)-cyclohexyl)-(3-chloro-benzo[b]thiophene-2-carbonyl)-amino]-methyl}-4-ethoxy-benzeneboronic acid

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Technology Process of trans-3-{[(4-(Boc-methyl-amino)-cyclohexyl)-(3-chloro-benzo[b]thiophene-2-carbonyl)-amino]-methyl}-4-ethoxy-benzeneboronic acid

There total 6 articles about trans-3-{[(4-(Boc-methyl-amino)-cyclohexyl)-(3-chloro-benzo[b]thiophene-2-carbonyl)-amino]-methyl}-4-ethoxy-benzeneboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 21815-91-8
3-chlorobenzo[b]thiophen-2-carbonyl chloride

: 945997-05-7
trans-3-{[4-(Boc-methyl-amino)-cyclohexylamino]-methyl}-4-ethoxy-benzeneboronic acid

: 945997-08-0
trans-3-{[(4-(Boc-methyl-amino)-cyclohexyl)-(3-chloro-benzo[b]thiophene-2-carbonyl)-amino]-methyl}-4-ethoxy-benzeneboronic acid

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h;

Reference yield:

: 15803-59-5,1932261-28-3,38362-02-6
(1r,4r)-N¹-methylcyclohexane-1,4-diamine

: 945997-08-0
trans-3-{[(4-(Boc-methyl-amino)-cyclohexyl)-(3-chloro-benzo[b]thiophene-2-carbonyl)-amino]-methyl}-4-ethoxy-benzeneboronic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzaldehyde / toluene / 6 h / Heating / reflux

1.2: 3.25 h / 20 °C

2.1: acetic acid / tetrahydrofuran; toluene / 2 h / 20 °C

2.2: 16 h / 20 °C

3.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

With benzaldehyde; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 566172-79-0
trans-N-methyl-N-tert-butoxycarbonyl-1,4-diaminocyclohexane

: 945997-08-0
trans-3-{[(4-(Boc-methyl-amino)-cyclohexyl)-(3-chloro-benzo[b]thiophene-2-carbonyl)-amino]-methyl}-4-ethoxy-benzeneboronic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / tetrahydrofuran; toluene / 2 h / 20 °C

1.2: 16 h / 20 °C

2.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

With acetic acid; triethylamine; In tetrahydrofuran; dichloromethane; toluene;