trans-3-{[4-(Boc-methyl-amino)-cyclohexylamino]-methyl}-4-ethoxy-benzeneboronic acid

Base Information

Chemical Name:trans-3-{[4-(Boc-methyl-amino)-cyclohexylamino]-methyl}-4-ethoxy-benzeneboronic acid
CAS No.:945997-05-7
Molecular Formula:C₂₁H₃₅BN₂O₅
Molecular Weight:406.33
Hs Code.:

Synonyms:trans-3-{[4-(Boc-methyl-amino)-cyclohexylamino]-methyl}-4-ethoxy-benzeneboronic acid

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Chemical Property of trans-3-{[4-(Boc-methyl-amino)-cyclohexylamino]-methyl}-4-ethoxy-benzeneboronic acid

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Technology Process of trans-3-{[4-(Boc-methyl-amino)-cyclohexylamino]-methyl}-4-ethoxy-benzeneboronic acid

There total 5 articles about trans-3-{[4-(Boc-methyl-amino)-cyclohexylamino]-methyl}-4-ethoxy-benzeneboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 480424-63-3
4-ethoxy-3-formylbenzene boronic acid

: 566172-79-0
trans-N-methyl-N-tert-butoxycarbonyl-1,4-diaminocyclohexane

: 945997-05-7
trans-3-{[4-(Boc-methyl-amino)-cyclohexylamino]-methyl}-4-ethoxy-benzeneboronic acid

Guidance literature:: 4-ethoxy-3-formylbenzene boronic acid; trans-N-methyl-N-tert-butoxycarbonyl-1,4-diaminocyclohexane; With acetic acid; In tetrahydrofuran; toluene; at 20 ℃; for 2h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; methanol; toluene; at 20 ℃; for 16h;

Reference yield:

: 566172-78-9
n-butyl trans-(4-aminocyclohexyl)-carbamate

: 945997-05-7
trans-3-{[4-(Boc-methyl-amino)-cyclohexylamino]-methyl}-4-ethoxy-benzeneboronic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 18.5 h / 0 °C / Heating / reflux

1.2: 2.16 h / 0 - 20 °C

2.1: benzaldehyde / toluene / 6 h / Heating / reflux

2.2: 3.25 h / 20 °C

3.1: acetic acid / tetrahydrofuran; toluene / 2 h / 20 °C

3.2: 16 h / 20 °C

With lithium aluminium tetrahydride; benzaldehyde; acetic acid; In tetrahydrofuran; toluene;

Reference yield:

: 15803-59-5,1932261-28-3,38362-02-6
(1r,4r)-N¹-methylcyclohexane-1,4-diamine

: 945997-05-7
trans-3-{[4-(Boc-methyl-amino)-cyclohexylamino]-methyl}-4-ethoxy-benzeneboronic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzaldehyde / toluene / 6 h / Heating / reflux

1.2: 3.25 h / 20 °C

2.1: acetic acid / tetrahydrofuran; toluene / 2 h / 20 °C

2.2: 16 h / 20 °C

With benzaldehyde; acetic acid; In tetrahydrofuran; toluene;