1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(4-chloro-2-methylphenyl)methyl)piperazine-1-carboxylate

Base Information

Chemical Name:1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(4-chloro-2-methylphenyl)methyl)piperazine-1-carboxylate
CAS No.:1446817-35-1
Molecular Formula:C₂₃H₂₂Cl₂F₆N₂O₂
Molecular Weight:543.336
Hs Code.:

Synonyms:1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(4-chloro-2-methylphenyl)methyl)piperazine-1-carboxylate

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Chemical Property of 1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(4-chloro-2-methylphenyl)methyl)piperazine-1-carboxylate

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Technology Process of 1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(4-chloro-2-methylphenyl)methyl)piperazine-1-carboxylate

There total 6 articles about 1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(4-chloro-2-methylphenyl)methyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 920-66-1
1,1,1,3',3',3'-hexafluoro-propanol

: 1446818-52-5
1-(bis(4-chloro-2-methylphenyl)methyl)piperazine

: 1446817-35-1
1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(4-chloro-2-methylphenyl)methyl)piperazine-1-carboxylate

Guidance literature:: bis(trichloromethyl) carbonate; 1,1,1,3',3',3'-hexafluoro-propanol; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

1-(bis(4-chloro-2-methylphenyl)methyl)piperazine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.8b00951

Reference yield:

: 480438-47-9
(4-chloro-2-methylphenyl)magnesium bromide

: 1446817-35-1
1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(4-chloro-2-methylphenyl)methyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / -78 - 20 °C / Inert atmosphere

2.1: thionyl chloride / dichloromethane / 24 h / 20 °C / Inert atmosphere

3.1: potassium carbonate / acetonitrile / 22 h / 80 - 120 °C / Inert atmosphere

4.1: 4-methyl-morpholine; trimethylsilyl iodide / dichloromethane / 0.25 h / 0 - 4 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

5.2: 2 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; thionyl chloride; trimethylsilyl iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/acs.jmedchem.8b00951

Reference yield:

: 1446818-51-4
tert-butyl 4-(bis(4-chloro-2-methylphenyl)methyl)piperazine-1-carboxylate

: 1446817-35-1
1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(4-chloro-2-methylphenyl)methyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4-methyl-morpholine; trimethylsilyl iodide / dichloromethane / 0.25 h / 0 - 4 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; trimethylsilyl iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/acs.jmedchem.8b00951