-2-carboxy-α-<<3-methyl-2-<<(4-methylphenyl)sulfonyl>amino>-1-oxobutyl>amino>benzenepropanoic acid

Base Information

Chemical Name:-2-carboxy-α-<<3-methyl-2-<<(4-methylphenyl)sulfonyl>amino>-1-oxobutyl>amino>benzenepropanoic acid
CAS No.:148671-94-7
Molecular Formula:C₂₂H₂₆N₂O₇S
Molecular Weight:462.524
Hs Code.:

<S-(R*,R*)>-2-carboxy-α-<<3-methyl-2-<<(4-methylphenyl)sulfonyl>amino>-1-oxobutyl>amino>benzenepropanoic acid

Synonyms:-2-carboxy-α-<<3-methyl-2-<<(4-methylphenyl)sulfonyl>amino>-1-oxobutyl>amino>benzenepropanoic acid

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Chemical Property of -2-carboxy-α-<<3-methyl-2-<<(4-methylphenyl)sulfonyl>amino>-1-oxobutyl>amino>benzenepropanoic acid

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Technology Process of -2-carboxy-α-<<3-methyl-2-<<(4-methylphenyl)sulfonyl>amino>-1-oxobutyl>amino>benzenepropanoic acid

There total 5 articles about -2-carboxy-α-<<3-methyl-2-<<(4-methylphenyl)sulfonyl>amino>-1-oxobutyl>amino>benzenepropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 148672-06-4
(S)-2-[(S)-3-Methyl-2-(toluene-4-sulfonylamino)-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid

: 148671-94-7
-2-carboxy-α-<<3-methyl-2-<<(4-methylphenyl)sulfonyl>amino>-1-oxobutyl>amino>benzenepropanoic acid

Guidance literature:: With potassium permanganate; potassium carbonate; In water; for 1.5h; Ambient temperature;
DOI:10.1021/ja00063a015

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 148671-94-7
-2-carboxy-α-<<3-methyl-2-<<(4-methylphenyl)sulfonyl>amino>-1-oxobutyl>amino>benzenepropanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / conc. HCl / 4 h / 90 - 95 °C

2: 76 percent / SOCl₂ / 4.5 h / Heating

3: 40 percent / Et₃N, DCC / CH₂Cl₂ / 24 h / Ambient temperature

4: 79 percent / H₂O, NaOH / methanol / 24 h / Ambient temperature

5: K₂CO₃, KMnO₄ / H₂O / 1.5 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; potassium permanganate; thionyl chloride; water; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; water;
DOI:10.1021/ja00063a015

Reference yield:

: 74163-81-8
L-Tic-OH

: 148671-94-7
-2-carboxy-α-<<3-methyl-2-<<(4-methylphenyl)sulfonyl>amino>-1-oxobutyl>amino>benzenepropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / SOCl₂ / 4.5 h / Heating

2: 40 percent / Et₃N, DCC / CH₂Cl₂ / 24 h / Ambient temperature

3: 79 percent / H₂O, NaOH / methanol / 24 h / Ambient temperature

4: K₂CO₃, KMnO₄ / H₂O / 1.5 h / Ambient temperature

With sodium hydroxide; potassium permanganate; thionyl chloride; water; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; water;
DOI:10.1021/ja00063a015