(4S,4aR,5S,6S,7R,8R,11S,12S,12aR)-6,12-bis(benzyloxy)-11-(cyclohexyldimethylsilyloxy)-4,5-(isopropylidenedioxy)-4a-(methoxymethoxymethyl)-8,13,13-trimethyl-1-methylenetetradecahydro-7,11-methanobenzocyclododecene-7,8-dilo

Base Information

• Chemical Name: (4S,4aR,5S,6S,7R,8R,11S,12S,12aR)-6,12-bis(benzyloxy)-11-(cyclohexyldimethylsilyloxy)-4,5-(isopropylidenedioxy)-4a-(methoxymethoxymethyl)-8,13,13-trimethyl-1-methylenetetradecahydro-7,11-methanobenzocyclododecene-7,8-dilo
• CAS No.: 815598-49-3
• Molecular Formula: C₄₇H₇₀O₉Si
• Molecular Weight: 807.153

Synonyms:(4S,4aR,5S,6S,7R,8R,11S,12S,12aR)-6,12-bis(benzyloxy)-11-(cyclohexyldimethylsilyloxy)-4,5-(isopropylidenedioxy)-4a-(methoxymethoxymethyl)-8,13,13-trimethyl-1-methylenetetradecahydro-7,11-methanobenzocyclododecene-7,8-dilo

Chemical Property of (4S,4aR,5S,6S,7R,8R,11S,12S,12aR)-6,12-bis(benzyloxy)-11-(cyclohexyldimethylsilyloxy)-4,5-(isopropylidenedioxy)-4a-(methoxymethoxymethyl)-8,13,13-trimethyl-1-methylenetetradecahydro-7,11-methanobenzocyclododecene-7,8-dilo

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S,4aR,5S,6S,7R,8R,11S,12S,12aR)-6,12-bis(benzyloxy)-11-(cyclohexyldimethylsilyloxy)-4,5-(isopropylidenedioxy)-4a-(methoxymethoxymethyl)-8,13,13-trimethyl-1-methylenetetradecahydro-7,11-methanobenzocyclododecene-7,8-dilo

There total 11 articles about (4S,4aR,5S,6S,7R,8R,11S,12S,12aR)-6,12-bis(benzyloxy)-11-(cyclohexyldimethylsilyloxy)-4,5-(isopropylidenedioxy)-4a-(methoxymethoxymethyl)-8,13,13-trimethyl-1-methylenetetradecahydro-7,11-methanobenzocyclododecene-7,8-dilo which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,2S,3S,5R,6S,7S,8R,9S)-2,6-bis(benzyloxy)-5-(t-butyldimethylsilyloxy)-7,9-(isopropylidenedioxy)-8-(methoxymethoxymethyl)-4,4-dimethyl-12-methylenebicyclo[6.4.0]dodecan-3-ol (815598-62-0) → (4S,4aR,5S,6S,7R,8R,11S,12S,12aR)-6,12-bis(benzyloxy)-11-(cyclohexyldimethylsilyloxy)-4,5-(isopropylidenedioxy)-4a-(methoxymethoxymethyl)-8,13,13-trimethyl-1-methylenetetradecahydro-7,11-methanobenzocyclododecene-7,8-dilo (815598-49-3)

Guidance literature:

Multi-step reaction with 8 steps

1: 95 percent / NaHCO₃; Dess-Martin periodinane / CH₂Cl₂ / 0.33 h / 20 °C

2: 97 percent / s-butyllithium / benzene; cyclohexane / 1 h / 0 °C

3: 80 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 1 h / 50 °C

4: 100 percent / imidazole / dimethylformamide / 0.17 h / 20 °C

5: 99 percent / tetrahydrofuran; hexamethylphosphoric acid triamide; diethyl ether / 0.5 h / -78 °C

6: 97 percent / NaHCO₃; Dess-Martim periodinane / CH₂Cl₂ / 0.33 h / 20 °C

7: 83 percent / palladium(II) chloride; H₂O / dimethylformamide / 3.5 h / 20 °C

8: 64 percent / titanium(II) chloride; lithium aluminium hydride / tetrahydrofuran / 0.33 h / 40 °C

With 1H-imidazole; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; water; sec.-butyllithium; titanium chloride; sodium hydrogencarbonate; Dess-Martin periodane; palladium dichloride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; cyclohexane; N,N-dimethyl-formamide; benzene;

DOI:10.1246/bcsj.78.677

Reference yield:

(1R,2S,3S,5R,6S,7S,8R,9S)-2,6-bis(benzyloxy)-3-(3-butenyl)-5-(t-butyldimethylsilyloxy)-7,9-(isopropylidenedioxy)-8-(methoxymethoxymethyl)-4,4-dimethyl-12-methylenebicyclo[6.4.0]dodecan-3-ol (815598-52-8) → (4S,4aR,5S,6S,7R,8R,11S,12S,12aR)-6,12-bis(benzyloxy)-11-(cyclohexyldimethylsilyloxy)-4,5-(isopropylidenedioxy)-4a-(methoxymethoxymethyl)-8,13,13-trimethyl-1-methylenetetradecahydro-7,11-methanobenzocyclododecene-7,8-dilo (815598-49-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 80 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 1 h / 50 °C

2: 100 percent / imidazole / dimethylformamide / 0.17 h / 20 °C

3: 99 percent / tetrahydrofuran; hexamethylphosphoric acid triamide; diethyl ether / 0.5 h / -78 °C

4: 97 percent / NaHCO₃; Dess-Martim periodinane / CH₂Cl₂ / 0.33 h / 20 °C

5: 83 percent / palladium(II) chloride; H₂O / dimethylformamide / 3.5 h / 20 °C

6: 64 percent / titanium(II) chloride; lithium aluminium hydride / tetrahydrofuran / 0.33 h / 40 °C

With 1H-imidazole; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; water; titanium chloride; sodium hydrogencarbonate; Dess-Martin periodane; palladium dichloride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1246/bcsj.78.677

Reference yield:

(1R,3R,4R,6R,7S,8R,12S)-3,7-bis(benzyloxy)-4-(t-butyldimethylsilyloxy)-12-hydroxy-1-methoxymethoxymethyl-6-(4-methoxybenzyloxy)-5,5-dimethyl-9-methylenebicyclo[6.4.0]dodecan-2-one (677751-25-6) → (4S,4aR,5S,6S,7R,8R,11S,12S,12aR)-6,12-bis(benzyloxy)-11-(cyclohexyldimethylsilyloxy)-4,5-(isopropylidenedioxy)-4a-(methoxymethoxymethyl)-8,13,13-trimethyl-1-methylenetetradecahydro-7,11-methanobenzocyclododecene-7,8-dilo (815598-49-3)

Guidance literature:

Multi-step reaction with 11 steps

1: 81 percent / LiAlH₄; sulfuric acid; water / tetrahydrofuran; toluene / 2 h / -23 °C

2: 92 percent / camphorsulfonic acid / CH₂Cl₂ / 5 h / 20 °C

3: 100 percent / phosphate buffer; 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂; H₂O / 1.5 h / 0 °C / pH 7

4: 95 percent / NaHCO₃; Dess-Martin periodinane / CH₂Cl₂ / 0.33 h / 20 °C

5: 97 percent / s-butyllithium / benzene; cyclohexane / 1 h / 0 °C

6: 80 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 1 h / 50 °C

7: 100 percent / imidazole / dimethylformamide / 0.17 h / 20 °C

8: 99 percent / tetrahydrofuran; hexamethylphosphoric acid triamide; diethyl ether / 0.5 h / -78 °C

9: 97 percent / NaHCO₃; Dess-Martim periodinane / CH₂Cl₂ / 0.33 h / 20 °C

10: 83 percent / palladium(II) chloride; H₂O / dimethylformamide / 3.5 h / 20 °C

11: 64 percent / titanium(II) chloride; lithium aluminium hydride / tetrahydrofuran / 0.33 h / 40 °C

With 1H-imidazole; lithium aluminium tetrahydride; phosphate buffer; sulfuric acid; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; water; sec.-butyllithium; titanium chloride; sodium hydrogencarbonate; Dess-Martin periodane; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium dichloride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; cyclohexane; water; N,N-dimethyl-formamide; toluene; benzene;

DOI:10.1246/bcsj.78.677

upstream raw materials:

(1R,3R,4R,6R,7S,8R,12S)-3,7-bis(benzyloxy)-4-(t-butyldimethylsilyloxy)-12-hydroxy-1-hydroxymethyl-6-(4-methoxybenzyloxy)-5,5-dimethyl-9-methylenebicyclo[6.4.0]dodecan-2-one

(1R,3R,4R,6R,7S,8R,12S)-3,7-bis(benzyloxy)-4-(t-butyldimethylsilyloxy)-12-hydroxy-1-methoxymethoxymethyl-6-(4-methoxybenzyloxy)-5,5-dimethyl-9-methylenebicyclo[6.4.0]dodecan-2-one

(1R,2S,5R,6S,7S,8R,9S)-2,6-bis(benzyloxy)-5-(t-butyldimethylsilyloxy)-7,9-(isopropylidenedioxy)-8-(methoxymethoxymethyl)-4,4-dimethyl-12-methylenebicyclo[6.4.0]dodecan-3-one

(1R,2S,3S,5R,6S,7S,8R,9S)-2,6-bis(benzyloxy)-3-(3-butenyl)-5-(t-butyldimethylsilyloxy)-7,9-(isopropylidenedioxy)-8-(methoxymethoxymethyl)-4,4-dimethyl-12-methylenebicyclo[6.4.0]dodecan-3-ol

Downstream raw materials:

(1S,4aR,5S,6S,9R,10R,11S,12S,12aR)-6-(cyclohexyldimethylsilyloxy)-1,12-(isopropylidenedioxy)-12a-(methoxymethoxymethyl)-9,13,13-trimethyl-4-methylenetetradecahydro-6,10-methanobenzocyclodecene-5,9,10,11-tetrol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 815598-49-3 (4S,4aR,5S,6S,7R,8R,11S,12S,12aR)-6,12-bis(benzyloxy)-11-(cyclohexyldimethylsilyloxy)-4,5-(isopropylidenedioxy)-4a-(methoxymethoxymethyl)-8,13,13-trimethyl-1-methylenetetradecahydro-7,11-methanobenzocyclododecene-7,8-dilo

Send

Send

Metric Ton KG G Pound L ML

Send

Send