4-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-ylamino]-α-(phenoxymethyl)-1-piperidineethanol

Base Information

Chemical Name:4-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-ylamino]-α-(phenoxymethyl)-1-piperidineethanol
CAS No.:75971-04-9
Molecular Formula:C₂₈H₃₁FN₄O₂
Molecular Weight:474.578
Hs Code.:

Synonyms:4-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-ylamino]-α-(phenoxymethyl)-1-piperidineethanol

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Chemical Property of 4-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-ylamino]-α-(phenoxymethyl)-1-piperidineethanol

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Technology Process of 4-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-ylamino]-α-(phenoxymethyl)-1-piperidineethanol

There total 5 articles about 4-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-ylamino]-α-(phenoxymethyl)-1-piperidineethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 122-60-1,71031-02-2
Phenyl glycidyl ether

: 75970-64-8
1-[(4-fluorophenyl)methyl]-N-(4-piperidinyl)-1H-benzimidazol-2-amine dihydrobromide

: 75971-04-9
4-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-ylamino]-α-(phenoxymethyl)-1-piperidineethanol

Guidance literature:: With sodium carbonate; In methanol; benzene; Heating;
DOI:10.1021/jm00150a029

Reference yield:

: 73734-07-3
(1H-benzimidazol-2-yl)-(1-ethoxycarbonyl-piperidin-4-yl)amine

: 75971-04-9
4-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-ylamino]-α-(phenoxymethyl)-1-piperidineethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / sodium carbonate, potassium iodide / dimethylformamide / 70 °C

2: 82 percent / 48 percent hydrobromic acid / 1 h / Heating

3: 32 percent / Na₂CO₃ / benzene; methanol / Heating

With hydrogen bromide; sodium carbonate; potassium iodide; In methanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00150a029

Reference yield:

: 84501-68-8
ethyl 4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinecarboxylate

: 75971-04-9
4-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-ylamino]-α-(phenoxymethyl)-1-piperidineethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / 48 percent hydrobromic acid / 1 h / Heating

2: 32 percent / Na₂CO₃ / benzene; methanol / Heating

With hydrogen bromide; sodium carbonate; In methanol; benzene;
DOI:10.1021/jm00150a029