3-(4-Methoxybenzyl)-5'-O-(triphenylmethyl)-2',3'-securidine

Base Information

• Chemical Name: 3-(4-Methoxybenzyl)-5'-O-(triphenylmethyl)-2',3'-securidine
• CAS No.: 157429-98-6
• Molecular Formula: C₃₆H₃₆N₂O₇
• Molecular Weight: 608.691
• Mol file: 157429-98-6.mol

Synonyms:3-(4-Methoxybenzyl)-5'-O-(triphenylmethyl)-2',3'-securidine

Chemical Property of 3-(4-Methoxybenzyl)-5'-O-(triphenylmethyl)-2',3'-securidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-Methoxybenzyl)-5'-O-(triphenylmethyl)-2',3'-securidine

There total 1 articles about 3-(4-Methoxybenzyl)-5'-O-(triphenylmethyl)-2',3'-securidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-(2-hydroxy-1-{[1-hydroxy-3-(triphenylmethoxy)propan-2-yl]oxy}ethyl)pyrimidine-2,4(1H,3H)-dione (101527-47-3) + p-methoxybenzyl chloride (824-94-2) → 3-(4-Methoxybenzyl)-5'-O-(triphenylmethyl)-2',3'-securidine (157429-98-6)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 60 ℃; for 1h;

DOI:10.1002/hlca.19950780714

Reference yield: 84.0%

p-toluenesulfonyl chloride (98-59-9) + 3-(4-Methoxybenzyl)-5'-O-(triphenylmethyl)-2',3'-securidine (157429-98-6) → 3-(4-methoxybenzyl)-2',3'-bis-O-<(tol-4-yl)sulfonyl>-5'-O-(triphenylmethyl)-2',3'-secouridine (173202-64-7)

Guidance literature:

In pyridine; Ambient temperature;

DOI:10.1002/hlca.19950780714

Reference yield:

3-(4-Methoxybenzyl)-5'-O-(triphenylmethyl)-2',3'-securidine (157429-98-6) → 3'-Azido-2',3'-dideoxy-5'-O-(triphenylmethyl)-2',3'-secouridin-1'-ene (173202-65-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent / pyridine / Ambient temperature

2: 33 percent / KO(t-Bu) / tetrahydrofuran / 75 h / 40 °C

3: 70 percent / NaN₃ / dimethylformamide / 18 h / 80 °C

4: 77 percent / AlCl₃ / various solvent(s) / 1 h / 60 °C

With aluminium trichloride; sodium azide; potassium tert-butylate; In tetrahydrofuran; pyridine; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19950780714

upstream raw materials:

1-(2-hydroxy-1-{[1-hydroxy-3-(triphenylmethoxy)propan-2-yl]oxy}ethyl)pyrimidine-2,4(1H,3H)-dione

p-methoxybenzyl chloride

Downstream raw materials:

3-(4-methoxybenzyl)-2',3'-bis-O-<(tol-4-yl)sulfonyl>-5'-O-(triphenylmethyl)-2',3'-secouridine

3'-Azido-2',3'-dideoxy-5'-O-(triphenylmethyl)-2',3'-secouridin-1'-ene

3'-Azido-2',3'-dodeoxy-3-(4-methoxybenzyl)-5'-O-(triphenylmethyl)-2',3'-secouridin-1'-ene

2'-Deoxy-3-(4-methoxybenxyl)-3'-O-<(tol-4-yl)sulfonyl>-5'-O-(triphenylmethyl)-2',3'-secouridin-1'-ene