6-((1E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(methylsulfonyl)amino)pyrimidin-5-yl)ethenyl)-2,2-dimethyl-1,3-dioxan-4yl acetic acid ethyl ester

Base Information

• Chemical Name: 6-((1E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(methylsulfonyl)amino)pyrimidin-5-yl)ethenyl)-2,2-dimethyl-1,3-dioxan-4yl acetic acid ethyl ester
• CAS No.: 851440-18-1
• Molecular Formula: C₂₇H₃₆FN₃O₆S
• Molecular Weight: 549.664
• Mol file: 851440-18-1.mol

Synonyms:6-((1E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(methylsulfonyl)amino)pyrimidin-5-yl)ethenyl)-2,2-dimethyl-1,3-dioxan-4yl acetic acid ethyl ester

Chemical Property of 6-((1E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(methylsulfonyl)amino)pyrimidin-5-yl)ethenyl)-2,2-dimethyl-1,3-dioxan-4yl acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-((1E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(methylsulfonyl)amino)pyrimidin-5-yl)ethenyl)-2,2-dimethyl-1,3-dioxan-4yl acetic acid ethyl ester

There total 4 articles about 6-((1E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(methylsulfonyl)amino)pyrimidin-5-yl)ethenyl)-2,2-dimethyl-1,3-dioxan-4yl acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4-acetic acid ethyl ester (915749-98-3) + N-{5-[(benzo[d]thiazol-2-ylsulfonyl)methyl]-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl}-N-methylmethanesulfonamide (1234331-55-5) → 6-((1E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(methylsulfonyl)amino)pyrimidin-5-yl)ethenyl)-2,2-dimethyl-1,3-dioxan-4yl acetic acid ethyl ester (851440-18-1)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at -30 ℃; Product distribution / selectivity;

Reference yield: 81.0%

(4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4-acetic acid ethyl ester (915749-98-3) + C31H34FN3O4PS(1+)*Br(1-) → 6-((1E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(methylsulfonyl)amino)pyrimidin-5-yl)ethenyl)-2,2-dimethyl-1,3-dioxan-4yl acetic acid ethyl ester (851440-18-1)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 70 - 80 ℃; stereoselective reaction;

Reference yield: 80.0%

(4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4-acetic acid ethyl ester (915749-98-3) + C32H36FN3O4PS(1+)*Br(1-) → 6-((1E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(methylsulfonyl)amino)pyrimidin-5-yl)ethenyl)-2,2-dimethyl-1,3-dioxan-4yl acetic acid ethyl ester (851440-18-1)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 70 - 80 ℃; stereoselective reaction;

upstream raw materials:

N-(5-((diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide

(4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4-acetic acid ethyl ester

N-{5-[(benzo[d]thiazol-2-ylsulfonyl)methyl]-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl}-N-methylmethanesulfonamide

Downstream raw materials:

{(4R,6S)-6-[(E)-2-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid

Rosuvastatin lactone