(1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid {(R)-2-hydroxy-1-[4-(2-methyl-pentyloxy)phenyl]ethyl}amide

Base Information

Chemical Name:(1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid {(R)-2-hydroxy-1-[4-(2-methyl-pentyloxy)phenyl]ethyl}amide
CAS No.:1286280-41-8
Molecular Formula:C₂₂H₂₉NO₃S
Molecular Weight:387.543
Hs Code.:

Synonyms:(1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid {(R)-2-hydroxy-1-[4-(2-methyl-pentyloxy)phenyl]ethyl}amide

Suppliers and Price of (1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid {(R)-2-hydroxy-1-[4-(2-methyl-pentyloxy)phenyl]ethyl}amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid {(R)-2-hydroxy-1-[4-(2-methyl-pentyloxy)phenyl]ethyl}amide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid {(R)-2-hydroxy-1-[4-(2-methyl-pentyloxy)phenyl]ethyl}amide

There total 9 articles about (1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid {(R)-2-hydroxy-1-[4-(2-methyl-pentyloxy)phenyl]ethyl}amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1286280-53-2
(1S,2S)-2-thiophen-2yl-cyclopropanecarboxylic chloride

: 1286280-73-6
(2R)-2-amino-2-[4-(2-methylpentyloxy)phenyl]ethanol hydrochloride

: 1286280-41-8
(1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid {(R)-2-hydroxy-1-[4-(2-methyl-pentyloxy)phenyl]ethyl}amide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1.5h; Cooling with ice; Inert atmosphere;

Reference yield:

: 36438-64-9
p-benzyloxystyrene

: 1286280-41-8
(1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid {(R)-2-hydroxy-1-[4-(2-methyl-pentyloxy)phenyl]ethyl}amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; tert-butylhypochlorite / water; propan-1-ol / 0.08 h / 20 °C

1.2: 0.1 h / Cooling with ice

1.3: 1.5 h / 0 °C

2.1: hydrogen / palladium on carbon / dichloromethane; ethanol / 20 °C / 760.05 Torr

3.1: caesium carbonate / N,N-dimethyl-formamide / 70 °C

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 1.5 h / 20 °C / Cooling with ice

5.1: triethylamine / dichloromethane / 1.5 h / 20 °C / Cooling with ice; Inert atmosphere

With hydrogenchloride; tert-butylhypochlorite; hydrogen; caesium carbonate; triethylamine; sodium hydroxide; palladium on carbon; In 1,4-dioxane; propan-1-ol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 1286280-41-8
(1S,2S)-2-thiophen-2-yl-cyclopropanecarboxylic acid {(R)-2-hydroxy-1-[4-(2-methyl-pentyloxy)phenyl]ethyl}amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

1.2: 3 h / 0 - 20 °C

2.1: sodium hydroxide; tert-butylhypochlorite / water; propan-1-ol / 0.08 h / 20 °C

2.2: 0.1 h / Cooling with ice

2.3: 1.5 h / 0 °C

3.1: hydrogen / palladium on carbon / dichloromethane; ethanol / 20 °C / 760.05 Torr

4.1: caesium carbonate / N,N-dimethyl-formamide / 70 °C

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 1.5 h / 20 °C / Cooling with ice

6.1: triethylamine / dichloromethane / 1.5 h / 20 °C / Cooling with ice; Inert atmosphere

With hydrogenchloride; n-butyllithium; tert-butylhypochlorite; hydrogen; caesium carbonate; triethylamine; sodium hydroxide; palladium on carbon; In tetrahydrofuran; 1,4-dioxane; propan-1-ol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;