1-(4-FLUOROPHENYL)-3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 1-(4-FLUOROPHENYL)-3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 288251-64-9
• Molecular Formula: C13H13 F N2 O2
• Molecular Weight: 248.25
• Mol file: 288251-64-9.mol

Synonyms:1-(4-FLUOROPHENYL)-3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER;BUTTPARK 85\18-81

Chemical Property of 1-(4-FLUOROPHENYL)-3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• PSA: 44.12000
• LogP: 2.49650

Purity/Quality:

97% ^*data from raw suppliers

Ethyl1-(4-fluorophenyl)-3-methyl-1H-pyrazole-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-FLUOROPHENYL)-3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

There total 3 articles about 1-(4-FLUOROPHENYL)-3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-fluorophenyhydrazine hydrochloride (823-85-8) + ethyl 2,4-diketopentanoate (615-79-2) → ethyl 1-(4-fluorophenyl)-5-methyl-1H-pyrazole-3-carboxylate (126129-41-7) + ethyl 1-(4-fluorophenyl)-3-methyl-1H-pyrazole-5-carboxylate (288251-64-9)

Guidance literature:

With potassium acetate; In ethanol;

Reference yield:

4-fluorophenylhydrazine (371-14-2) + ethyl 2,4-diketopentanoate (615-79-2) → ethyl 1-(4-fluorophenyl)-3-methyl-1H-pyrazole-5-carboxylate (288251-64-9)

Guidance literature:

4-fluorophenylhydrazine; ethyl 2,4-diketopentanoate; In ethanol; at 0 ℃; for 1h;

With acetic acid; In ethanol; at 20 ℃; for 4h;

DOI:10.3184/174751911X13149561530439

Reference yield:

4-fluorophenylhydrazine (371-14-2) + ethyl 2,4-diketopentanoate (615-79-2) → ethyl 1-(4-fluorophenyl)-5-methyl-1H-pyrazole-3-carboxylate (126129-41-7) + ethyl 1-(4-fluorophenyl)-3-methyl-1H-pyrazole-5-carboxylate (288251-64-9)

Guidance literature:

for 3h; Heating / reflux;

upstream raw materials:

4-fluorophenylhydrazine

ethyl 2,4-diketopentanoate

4-fluorophenyhydrazine hydrochloride

Downstream raw materials:

1-(4-fluorophenyl)-3-methyl-1H-pyrazole-5-carboxylic acid

C₁₁H₈ClFN₂O

1-(4-fluorophenyl)-3-methyl-N-(1H-tetrazol-5-yl)-1H-pyrazole-5-carboxamide

2-(2-(5-fluorouracil-1-yl)acetamido)ethyl 1-(4-fluorophenyl)-3-methyl-1H-pyrazole-5-carboxylate

Refernces

• 1、 -. "PYRAZOLOALKYL SUBSTITUTED IMIDAZO RING COMPOUNDS AND METHODS". Page/Page column 83. . Retrieved 2008/06/13.