(+/-)-N₂-(1-chloroethoxycarbonyl)-N₄-(2,2-dimethyl-3-oxo-4H-5-pyrido[1,4]oxazin-6-yl)-5-fluoro-N₂-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine

Base Information

• Chemical Name: (+/-)-N₂-(1-chloroethoxycarbonyl)-N₄-(2,2-dimethyl-3-oxo-4H-5-pyrido[1,4]oxazin-6-yl)-5-fluoro-N₂-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine
• CAS No.: 940310-12-3
• Molecular Formula: C₂₅H₂₆ClFN₆O₇
• Molecular Weight: 576.969

Synonyms:(+/-)-N₂-(1-chloroethoxycarbonyl)-N₄-(2,2-dimethyl-3-oxo-4H-5-pyrido[1,4]oxazin-6-yl)-5-fluoro-N₂-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine

Chemical Property of (+/-)-N₂-(1-chloroethoxycarbonyl)-N₄-(2,2-dimethyl-3-oxo-4H-5-pyrido[1,4]oxazin-6-yl)-5-fluoro-N₂-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine

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Technology Process of (+/-)-N₂-(1-chloroethoxycarbonyl)-N₄-(2,2-dimethyl-3-oxo-4H-5-pyrido[1,4]oxazin-6-yl)-5-fluoro-N₂-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine

There total 1 articles about (+/-)-N₂-(1-chloroethoxycarbonyl)-N₄-(2,2-dimethyl-3-oxo-4H-5-pyrido[1,4]oxazin-6-yl)-5-fluoro-N₂-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one (841290-80-0) + carbonochloridic acid 1-chloro-ethyl ester (50893-53-3) → (+/-)-N2-(1-chloroethoxycarbonyl)-N4-(2,2-dimethyl-3-oxo-4H-5-pyrido[1,4]oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine (940310-12-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dicholoroethane; ethyl acetate; at -78 - 20 ℃; for 1.08333h;

Reference yield:

(+/-)-N2-(1-chloroethoxycarbonyl)-N4-(2,2-dimethyl-3-oxo-4H-5-pyrido[1,4]oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine (940310-12-3) → (+/-)-N4-(2,2-dimethyl-3-oxo-4H-5-pyrido[1,4]oxazin-6-yl)-5-fluoro-N2-[[1(1-pyridinium)ethoxy-carbonyl]]-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine iodide salt

Guidance literature:

With pyridine; sodium iodide; In acetone; at 20 ℃; for 24h;

upstream raw materials:

6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one

carbonochloridic acid 1-chloro-ethyl ester

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