N,N-diisopropyl-6-(hydroxydiphenylmethyl)-2-(trimethylsilyl)-1-cyclohexenecarboxamide

Base Information

Chemical Name:N,N-diisopropyl-6-(hydroxydiphenylmethyl)-2-(trimethylsilyl)-1-cyclohexenecarboxamide
CAS No.:80997-63-3
Molecular Formula:C₂₉H₄₁NO₂Si
Molecular Weight:463.736
Hs Code.:

Synonyms:N,N-diisopropyl-6-(hydroxydiphenylmethyl)-2-(trimethylsilyl)-1-cyclohexenecarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N,N-diisopropyl-6-(hydroxydiphenylmethyl)-2-(trimethylsilyl)-1-cyclohexenecarboxamide

Chemical Property:

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Technology Process of N,N-diisopropyl-6-(hydroxydiphenylmethyl)-2-(trimethylsilyl)-1-cyclohexenecarboxamide

There total 4 articles about N,N-diisopropyl-6-(hydroxydiphenylmethyl)-2-(trimethylsilyl)-1-cyclohexenecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 119-61-9
benzophenone

: 80997-59-7
N,N-diisopropyl-6-(trimethylsilyl)-1-cyclohexenecarboxamide

: 80997-63-3
N,N-diisopropyl-6-(hydroxydiphenylmethyl)-2-(trimethylsilyl)-1-cyclohexenecarboxamide

Guidance literature:: With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; 1.) -78 deg C, 5 min; 2.) -78 deg C, 15 min;
DOI:10.1021/ja00302a024

Reference yield:

: 636-82-8
cyclohexene-1-carboxylic acid

: 80997-63-3
N,N-diisopropyl-6-(hydroxydiphenylmethyl)-2-(trimethylsilyl)-1-cyclohexenecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 2.5 h / Heating

2: diethyl ether / 4 h / Ambient temperature

3: 57 percent / sec-BuLi, TMEDA / tetrahydrofuran / 1.) -78 deg C, 15 min; 2.) -78 deg C to RT

4: 90 percent / sec-BuLi, TMEDA / tetrahydrofuran / 1.) -78 deg C, 5 min; 2.) -78 deg C, 15 min

With thionyl chloride; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ja00302a024

Reference yield:

: 80997-37-1
N,N-diisopropyl-1-cyclohexenecarboxamide

: 80997-63-3
N,N-diisopropyl-6-(hydroxydiphenylmethyl)-2-(trimethylsilyl)-1-cyclohexenecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 57 percent / sec-BuLi, TMEDA / tetrahydrofuran / 1.) -78 deg C, 15 min; 2.) -78 deg C to RT

2: 90 percent / sec-BuLi, TMEDA / tetrahydrofuran / 1.) -78 deg C, 5 min; 2.) -78 deg C, 15 min

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran;
DOI:10.1021/ja00302a024