5-Hydroxy-2-(4-hydroxyphenyl)-1-(6-methansulfonyloxyhexyl)-3-methylindole

Base Information

Chemical Name:5-Hydroxy-2-(4-hydroxyphenyl)-1-(6-methansulfonyloxyhexyl)-3-methylindole
CAS No.:130628-37-4
Molecular Formula:C₂₂H₂₇NO₅S
Molecular Weight:417.526
Hs Code.:

Synonyms:5-Hydroxy-2-(4-hydroxyphenyl)-1-(6-methansulfonyloxyhexyl)-3-methylindole

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Chemical Property of 5-Hydroxy-2-(4-hydroxyphenyl)-1-(6-methansulfonyloxyhexyl)-3-methylindole

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Technology Process of 5-Hydroxy-2-(4-hydroxyphenyl)-1-(6-methansulfonyloxyhexyl)-3-methylindole

There total 7 articles about 5-Hydroxy-2-(4-hydroxyphenyl)-1-(6-methansulfonyloxyhexyl)-3-methylindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 130628-36-3
5-(tert-Butyldimethylsiloxy)-2-<4-(tert-butyldimethylsiloxy)phenyl>-1-(6-methansulfonyloxyhexyl)-3-methylindole

: 130628-37-4
5-Hydroxy-2-(4-hydroxyphenyl)-1-(6-methansulfonyloxyhexyl)-3-methylindole

Guidance literature:: With toluene-4-sulfonic acid; In ethyl acetate; at 40 ℃; for 0.5h;
DOI:10.1002/ardp.19903230804

Reference yield:

: 25542-62-5
6-bromo-hexanoic acid ethyl ester

: 130628-37-4
5-Hydroxy-2-(4-hydroxyphenyl)-1-(6-methansulfonyloxyhexyl)-3-methylindole

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH (80 percent) / 1.) DMF, 45 min, 2.a) 0 deg C, b.) 4 h, room temperature

2: BBr₃ / CH₂Cl₂ / 1.) 30 min, 0 deg C, 2.) 2 h, room temperature

3: 43 percent / imidazole / dimethylformamide / 10 h / 35 °C

4: 94 percent / LiAlH₄ / diethyl ether / 1 h / Heating

5: 72 percent / NEt₃ / tetrahydrofuran / 0.33 h

6: 79 percent / p-toluenesulfonic acid monohydrate / ethyl acetate / 0.5 h / 40 °C

With 1H-imidazole; lithium aluminium tetrahydride; boron tribromide; sodium hydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1002/ardp.19903230804

Reference yield:

: 91444-18-7
5-methoxy-2-(4-methoxyphenyl)-3-methyl-1H-indole

: 130628-37-4
5-Hydroxy-2-(4-hydroxyphenyl)-1-(6-methansulfonyloxyhexyl)-3-methylindole

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH (80 percent) / 1.) DMF, 45 min, 2.a) 0 deg C, b.) 4 h, room temperature

2: BBr₃ / CH₂Cl₂ / 1.) 30 min, 0 deg C, 2.) 2 h, room temperature

3: 43 percent / imidazole / dimethylformamide / 10 h / 35 °C

4: 94 percent / LiAlH₄ / diethyl ether / 1 h / Heating

5: 72 percent / NEt₃ / tetrahydrofuran / 0.33 h

6: 79 percent / p-toluenesulfonic acid monohydrate / ethyl acetate / 0.5 h / 40 °C

With 1H-imidazole; lithium aluminium tetrahydride; boron tribromide; sodium hydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1002/ardp.19903230804