cyclobutanecarboxylic acid 4-nitrophenyl ester

Base Information

• Chemical Name: cyclobutanecarboxylic acid 4-nitrophenyl ester
• CAS No.: 321865-45-6
• Molecular Formula: C₁₁H₁₁NO₄
• Molecular Weight: 221.213

Synonyms:cyclobutanecarboxylic acid 4-nitrophenyl ester

Chemical Property of cyclobutanecarboxylic acid 4-nitrophenyl ester

Chemical Property:

Purity/Quality:

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Technology Process of cyclobutanecarboxylic acid 4-nitrophenyl ester

There total 10 articles about cyclobutanecarboxylic acid 4-nitrophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.8%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + Cyclobutanecarboxylic acid (3721-95-7) → cyclobutanecarboxylic acid 4-nitrophenyl ester (321865-45-6)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dimethyl sulfoxide; at 20 ℃; for 8h;

DOI:10.1016/j.molcatb.2011.07.010

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → cyclobutanecarboxylic acid 4-nitrophenyl ester (321865-45-6)

Guidance literature:

Multi-step reaction with 15 steps

1: dmap; dicyclohexyl-carbodiimide / dimethyl sulfoxide / 8 h / 20 °C

2: Candida antarctica lipase B / dimethyl sulfoxide / 0.05 h / 30 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

3: dmap; dicyclohexyl-carbodiimide / dimethyl sulfoxide / 8 h / 20 °C

4: Candida antarctica lipase B / dimethyl sulfoxide / 0.05 h / 30 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

5: dmap; dicyclohexyl-carbodiimide / dimethyl sulfoxide / 8 h / 20 °C

6: Bacillus subtilis 168 SrfAD esterase / dimethyl sulfoxide / 0.05 h / 30 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

7: dmap; dicyclohexyl-carbodiimide / dimethyl sulfoxide / 8 h / 20 °C

8: Candida antarctica lipase B / dimethyl sulfoxide / 0.05 h / 30 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

9: dmap; dicyclohexyl-carbodiimide / dimethyl sulfoxide / 8 h / 20 °C

10: Candida antarctica lipase B / dimethyl sulfoxide / 0.05 h / 30 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

11: dmap; dicyclohexyl-carbodiimide / dimethyl sulfoxide / 8 h / 20 °C

12: Candida antarctica lipase B / dimethyl sulfoxide / 0.05 h / 30 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

13: dmap; dicyclohexyl-carbodiimide / dimethyl sulfoxide / 8 h / 20 °C

14: Bacillus subtilis 168 SrfAD esterase / dimethyl sulfoxide / 0.05 h / 30 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

15: dmap; dicyclohexyl-carbodiimide / dimethyl sulfoxide / 8 h / 20 °C

With dmap; Candida antarctica lipase B; Bacillus subtilis 168 SrfAD esterase; dicyclohexyl-carbodiimide; In dimethyl sulfoxide;

DOI:10.1016/j.molcatb.2011.07.010

Reference yield:

4-nitrophenyl decanoate (1956-09-8) → cyclobutanecarboxylic acid 4-nitrophenyl ester (321865-45-6)

Guidance literature:

Multi-step reaction with 12 steps

1: Candida antarctica lipase B / dimethyl sulfoxide / 0.05 h / 30 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

2: dmap; dicyclohexyl-carbodiimide / dimethyl sulfoxide / 8 h / 20 °C

3: Bacillus subtilis 168 SrfAD esterase / dimethyl sulfoxide / 0.05 h / 30 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

4: dmap; dicyclohexyl-carbodiimide / dimethyl sulfoxide / 8 h / 20 °C

5: Candida antarctica lipase B / dimethyl sulfoxide / 0.05 h / 30 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

6: dmap; dicyclohexyl-carbodiimide / dimethyl sulfoxide / 8 h / 20 °C

7: Candida antarctica lipase B / dimethyl sulfoxide / 0.05 h / 30 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

8: dmap; dicyclohexyl-carbodiimide / dimethyl sulfoxide / 8 h / 20 °C

9: Candida antarctica lipase B / dimethyl sulfoxide / 0.05 h / 30 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

10: dmap; dicyclohexyl-carbodiimide / dimethyl sulfoxide / 8 h / 20 °C

11: Bacillus subtilis 168 SrfAD esterase / dimethyl sulfoxide / 0.05 h / 30 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

12: dmap; dicyclohexyl-carbodiimide / dimethyl sulfoxide / 8 h / 20 °C

With dmap; Candida antarctica lipase B; Bacillus subtilis 168 SrfAD esterase; dicyclohexyl-carbodiimide; In dimethyl sulfoxide;

DOI:10.1016/j.molcatb.2011.07.010

upstream raw materials:

4-nitro-phenol

Cyclobutanecarbonyl chloride

Cyclobutanecarboxylic acid

4-nitrophenyl 4-methylpentanoate

Downstream raw materials:

4-nitro-phenol

p-nitrophenyl butyrate

cyclohexanecarboxylic acid 4-nitrophenyl ester

p-nitrophenylbenzoate

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