ethyl [4-(3-tert-butyl-5-{[(1,3-thiazol-2-ylamino)carbonyl]amino}-1H-pyrazol-1-yl)phenyl]acetate

Base Information

Chemical Name:ethyl [4-(3-tert-butyl-5-{[(1,3-thiazol-2-ylamino)carbonyl]amino}-1H-pyrazol-1-yl)phenyl]acetate
CAS No.:1357621-29-4
Molecular Formula:C₂₁H₂₅N₅O₃S
Molecular Weight:427.527
Hs Code.:

Synonyms:ethyl [4-(3-tert-butyl-5-{[(1,3-thiazol-2-ylamino)carbonyl]amino}-1H-pyrazol-1-yl)phenyl]acetate

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Chemical Property of ethyl [4-(3-tert-butyl-5-{[(1,3-thiazol-2-ylamino)carbonyl]amino}-1H-pyrazol-1-yl)phenyl]acetate

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Technology Process of ethyl [4-(3-tert-butyl-5-{[(1,3-thiazol-2-ylamino)carbonyl]amino}-1H-pyrazol-1-yl)phenyl]acetate

There total 3 articles about ethyl [4-(3-tert-butyl-5-{[(1,3-thiazol-2-ylamino)carbonyl]amino}-1H-pyrazol-1-yl)phenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96-50-4
2-thiazolylamine

: 1357621-07-8
ethyl [4-(3-tert-butyl-5-{[(2,2,2-trichloroethoxy)carbonyl]amino}-1H-pyrazol-1-yl)phenyl]acetate

: 1357621-29-4
ethyl [4-(3-tert-butyl-5-{[(1,3-thiazol-2-ylamino)carbonyl]amino}-1H-pyrazol-1-yl)phenyl]acetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 60 ℃; Microwave irradiation;
DOI:10.1016/j.ejmech.2011.11.019

Reference yield:

: 1197-55-3
4-aminophenylacetic acid

: 1357621-29-4
ethyl [4-(3-tert-butyl-5-{[(1,3-thiazol-2-ylamino)carbonyl]amino}-1H-pyrazol-1-yl)phenyl]acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C

1.2: 2 h / 0 - 20 °C

2.1: Reflux

3.1: sodium hydroxide / water; ethyl acetate / 2.5 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 60 °C / Microwave irradiation

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sodium nitrite; In water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1016/j.ejmech.2011.11.019

Reference yield:

: 57412-05-2,65476-32-6
p-carboxymethylphenylhydrazine hydrochloride

: 1357621-29-4
ethyl [4-(3-tert-butyl-5-{[(1,3-thiazol-2-ylamino)carbonyl]amino}-1H-pyrazol-1-yl)phenyl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: Reflux

2: sodium hydroxide / water; ethyl acetate / 2.5 h / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 60 °C / Microwave irradiation

With N-ethyl-N,N-diisopropylamine; sodium hydroxide; In water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1016/j.ejmech.2011.11.019