p-carboxymethylphenylhydrazine hydrochloride

Base Information

• Chemical Name: p-carboxymethylphenylhydrazine hydrochloride
• CAS No.: 57412-05-2
• Molecular Formula: C₈H₁₀N₂O₂*ClH
• Molecular Weight: 202.641
• Mol file: 57412-05-2.mol

Synonyms:

Chemical Property of p-carboxymethylphenylhydrazine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of p-carboxymethylphenylhydrazine hydrochloride

There total 2 articles about p-carboxymethylphenylhydrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-aminophenylacetic acid (1197-55-3) → p-carboxymethylphenylhydrazine hydrochloride (57412-05-2,65476-32-6)

Guidance literature:

4-aminophenylacetic acid; With hydrogenchloride; at 120 ℃;

With sodium nitrite; at -5 ℃; for 0.25h;

With hydrogenchloride; tin(ll) chloride; at -20 - -5 ℃; Further stages.;

DOI:10.1021/jm0705096

Reference yield:

→ p-carboxymethylphenylhydrazine hydrochloride (57412-05-2,65476-32-6)

Guidance literature:

p-Aminophenylessigsaeure, 1) HCl-saure Lsg., Diazotierung, 2) SnCl2;

Reference yield: 54.0%

4,4,4-trifluoro-1-(4-methylphenyl)butane-1,3-dione (720-94-5) + p-carboxymethylphenylhydrazine hydrochloride (57412-05-2,65476-32-6) → C19H15F3N2O2

Guidance literature:

In acetonitrile; at 200 ℃; for 0.05h; microwave irradiation;

DOI:10.1021/jm0705096

upstream raw materials:

4-aminophenylacetic acid

Downstream raw materials:

3-[trans-N-(benzyloxycarbonyl)cyclobutanamine]-1H-indol-5-ylacetic acid

ethyl 2-(4-(5-amino-3-cyclopentyl-1H-pyrazol-1-yl)phenyl)acetate

ethyl [4-(3-tert-butyl-5-{[(2,2,2-trichloroethoxy)carbonyl]amino}-1H-pyrazol-1-yl)phenyl]acetate

ethyl [4-(3-cyclopentyl-5-{[(2,2,2-trichloroethoxy)carbonyl]amino}-1H-pyrazol-1-yl)phenyl]acetate