([1,3]dioxolo[4,5-g]quinazolin-8-yl)-(3'-chloro-4'-fluorophenyl)amine hydrochloride

Base Information

• Chemical Name: ([1,3]dioxolo[4,5-g]quinazolin-8-yl)-(3'-chloro-4'-fluorophenyl)amine hydrochloride
• CAS No.: 1266868-75-0
• Molecular Formula: C₁₅H₉ClFN₃O₂*ClH
• Molecular Weight: 354.168
• Mol file: 1266868-75-0.mol

Synonyms:([1,3]dioxolo[4,5-g]quinazolin-8-yl)-(3'-chloro-4'-fluorophenyl)amine hydrochloride

Chemical Property of ([1,3]dioxolo[4,5-g]quinazolin-8-yl)-(3'-chloro-4'-fluorophenyl)amine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ([1,3]dioxolo[4,5-g]quinazolin-8-yl)-(3'-chloro-4'-fluorophenyl)amine hydrochloride

There total 6 articles about ([1,3]dioxolo[4,5-g]quinazolin-8-yl)-(3'-chloro-4'-fluorophenyl)amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3-chloro-4-fluorophenylamine (367-21-5) + 8-chloro-[1,3]dioxolo[4,5-g]quinazoline (72700-23-3) → ([1,3]dioxolo[4,5-g]quinazolin-8-yl)-(3'-chloro-4'-fluorophenyl)amine hydrochloride (1266868-75-0)

Guidance literature:

In isopropyl alcohol; at 80 ℃; Microwave irradiation;

DOI:10.1021/jm901338g

Reference yield:

Piperonylic acid (94-53-1) → ([1,3]dioxolo[4,5-g]quinazolin-8-yl)-(3'-chloro-4'-fluorophenyl)amine hydrochloride (1266868-75-0)

Guidance literature:

Multi-step reaction with 6 steps

1: thionyl chloride / Reflux

2: nitric acid; tin(IV) chloride / dichloromethane / -70 °C

3: hydrogen / methanol / 20 °C

4: sodium methylate / methanol; N,N-dimethyl-formamide / 110 °C

5: trichlorophosphate / Reflux

6: isopropyl alcohol / 3 h / Reflux

With thionyl chloride; hydrogen; nitric acid; sodium methylate; tin(IV) chloride; trichlorophosphate; In methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1021/jm1009605

Reference yield:

6,7-methylenedioxyquinazoline-4(3H)-one (28310-11-4) → ([1,3]dioxolo[4,5-g]quinazolin-8-yl)-(3'-chloro-4'-fluorophenyl)amine hydrochloride (1266868-75-0)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / Reflux

2: isopropyl alcohol / 3 h / Reflux

With trichlorophosphate; In isopropyl alcohol;

DOI:10.1021/jm1009605

upstream raw materials:

3-chloro-4-fluorophenylamine

8-chloro-[1,3]dioxolo[4,5-g]quinazoline

6,7-methylenedioxyquinazoline-4(3H)-one

Piperonylic acid

Downstream raw materials:

4-(N-methyl-3-chloro-4-fluoroanilino)-6,7-methylenedioxyquinazoline