4-(N-methyl-3-chloro-4-fluoroanilino)-6,7-methylenedioxyquinazoline

Base Information

Chemical Name:4-(N-methyl-3-chloro-4-fluoroanilino)-6,7-methylenedioxyquinazoline
CAS No.:1256394-35-0
Molecular Formula:C₁₆H₁₁ClFN₃O₂
Molecular Weight:331.734
Hs Code.:

Synonyms:4-(N-methyl-3-chloro-4-fluoroanilino)-6,7-methylenedioxyquinazoline

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Chemical Property of 4-(N-methyl-3-chloro-4-fluoroanilino)-6,7-methylenedioxyquinazoline

Chemical Property:

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Technology Process of 4-(N-methyl-3-chloro-4-fluoroanilino)-6,7-methylenedioxyquinazoline

There total 7 articles about 4-(N-methyl-3-chloro-4-fluoroanilino)-6,7-methylenedioxyquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1266868-75-0
([1,3]dioxolo[4,5-g]quinazolin-8-yl)-(3'-chloro-4'-fluorophenyl)amine hydrochloride

: 74-88-4
methyl iodide

: 1256394-35-0
4-(N-methyl-3-chloro-4-fluoroanilino)-6,7-methylenedioxyquinazoline

Guidance literature:: ([1,3]dioxolo[4,5-g]quinazolin-8-yl)-(3'-chloro-4'-fluorophenyl)amine hydrochloride; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 5h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 16h;
DOI:10.1021/jm1009605

Reference yield:

: 28310-11-4
6,7-methylenedioxyquinazoline-4(3H)-one

: 1256394-35-0
4-(N-methyl-3-chloro-4-fluoroanilino)-6,7-methylenedioxyquinazoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / Reflux

2.1: isopropyl alcohol / 3 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 5 h / 20 °C / Inert atmosphere

3.2: 16 h / 20 °C

With sodium hydride; trichlorophosphate; In N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;
DOI:10.1021/jm1009605

Reference yield:

: 94-53-1
Piperonylic acid

: 1256394-35-0
4-(N-methyl-3-chloro-4-fluoroanilino)-6,7-methylenedioxyquinazoline

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / Reflux

2.1: nitric acid; tin(IV) chloride / dichloromethane / -70 °C

3.1: hydrogen / methanol / 20 °C

4.1: sodium methylate / methanol; N,N-dimethyl-formamide / 110 °C

5.1: trichlorophosphate / Reflux

6.1: isopropyl alcohol / 3 h / Reflux

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 5 h / 20 °C / Inert atmosphere

7.2: 16 h / 20 °C

With thionyl chloride; hydrogen; nitric acid; sodium methylate; tin(IV) chloride; sodium hydride; trichlorophosphate; In methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;
DOI:10.1021/jm1009605