(E)-3-[(2S,3S)-3-(4-Methoxy-benzyloxymethyl)-2-methyl-oxiranyl]-acrylic acid methyl ester

Base Information

Chemical Name:(E)-3-[(2S,3S)-3-(4-Methoxy-benzyloxymethyl)-2-methyl-oxiranyl]-acrylic acid methyl ester
CAS No.:585526-27-8
Molecular Formula:C₁₆H₂₀O₅
Molecular Weight:292.332
Hs Code.:

Synonyms:(E)-3-[(2S,3S)-3-(4-Methoxy-benzyloxymethyl)-2-methyl-oxiranyl]-acrylic acid methyl ester

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Chemical Property of (E)-3-[(2S,3S)-3-(4-Methoxy-benzyloxymethyl)-2-methyl-oxiranyl]-acrylic acid methyl ester

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Technology Process of (E)-3-[(2S,3S)-3-(4-Methoxy-benzyloxymethyl)-2-methyl-oxiranyl]-acrylic acid methyl ester

There total 8 articles about (E)-3-[(2S,3S)-3-(4-Methoxy-benzyloxymethyl)-2-methyl-oxiranyl]-acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 167687-19-6
(2E)-4-[(4-methoxyphenyl)methoxy]-2-methylbut-2-en-1-ol

: 585526-27-8
(E)-3-[(2S,3S)-3-(4-Methoxy-benzyloxymethyl)-2-methyl-oxiranyl]-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / TBHP; (+)-DET; MS 4 Angstroem / Ti(O-iPr)4 / CH₂Cl₂ / 24 h / -25 °C

2: (COCl)2; DMSO; triethylamine / CH₂Cl₂ / 1 h / -78 °C

3: benzene / 1 h / 20 °C

With tert.-butylhydroperoxide; oxalyl dichloride; diethyl (2R,3R)-tartrate; MS 4 Angstroem; dimethyl sulfoxide; triethylamine; titanium(IV) isopropylate; In dichloromethane; benzene;
DOI:10.1021/ol052039k

Reference yield:

: 109786-74-5,109786-77-8,13807-95-9
(±)-3-(4-methoxybenzyloxy)propane-1,2-diol

: 585526-27-8
(E)-3-[(2S,3S)-3-(4-Methoxy-benzyloxymethyl)-2-methyl-oxiranyl]-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: Pb(OAc)4 / toluene / 3 h / 20 °C

2: tetrahydrofuran / 24 h / 20 °C

3: 92 percent / DIBAH / diethyl ether / 0.25 h / 20 °C

4: 84 percent / TBHP; (+)-DET; MS 4 Angstroem / Ti(O-iPr)4 / CH₂Cl₂ / 24 h / -25 °C

5: (COCl)2; DMSO; triethylamine / CH₂Cl₂ / 1 h / -78 °C

6: benzene / 1 h / 20 °C

With lead(IV) acetate; tert.-butylhydroperoxide; oxalyl dichloride; diethyl (2R,3R)-tartrate; MS 4 Angstroem; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; titanium(IV) isopropylate; In tetrahydrofuran; diethyl ether; dichloromethane; toluene; benzene;
DOI:10.1021/ol052039k

Reference yield:

: 14289-62-4
1-(allyloxymethyl)-4-methoxybenzene

: 585526-27-8
(E)-3-[(2S,3S)-3-(4-Methoxy-benzyloxymethyl)-2-methyl-oxiranyl]-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: OsO₄; NMO / acetone; H₂O; 2-methyl-propan-2-ol / 72 h / 20 °C

2: Pb(OAc)4 / toluene / 3 h / 20 °C

3: tetrahydrofuran / 24 h / 20 °C

4: 92 percent / DIBAH / diethyl ether / 0.25 h / 20 °C

5: 84 percent / TBHP; (+)-DET; MS 4 Angstroem / Ti(O-iPr)4 / CH₂Cl₂ / 24 h / -25 °C

6: (COCl)2; DMSO; triethylamine / CH₂Cl₂ / 1 h / -78 °C

7: benzene / 1 h / 20 °C

With lead(IV) acetate; tert.-butylhydroperoxide; osmium(VIII) oxide; N-methyl-2-indolinone; oxalyl dichloride; diethyl (2R,3R)-tartrate; MS 4 Angstroem; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; titanium(IV) isopropylate; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetone; toluene; tert-butyl alcohol; benzene;
DOI:10.1021/ol052039k