tert-Butyl-{(1R,2S)-1-(4-methoxy-benzyloxymethyl)-4-[(2S,5S,6R)-2-methoxy-6-(4-methoxy-benzyloxymethyl)-5-methyl-tetrahydro-pyran-2-yl]-2-methyl-butoxy}-dimethyl-silane

Base Information

Chemical Name:tert-Butyl-{(1R,2S)-1-(4-methoxy-benzyloxymethyl)-4-[(2S,5S,6R)-2-methoxy-6-(4-methoxy-benzyloxymethyl)-5-methyl-tetrahydro-pyran-2-yl]-2-methyl-butoxy}-dimethyl-silane
CAS No.:585526-33-6
Molecular Formula:C₃₆H₅₈O₇Si
Molecular Weight:630.938
Hs Code.:

tert-Butyl-{(1R,2S)-1-(4-methoxy-benzyloxymethyl)-4-[(2S,5S,6R)-2-methoxy-6-(4-methoxy-benzyloxymethyl)-5-methyl-tetrahydro-pyran-2-yl]-2-methyl-butoxy}-dimethyl-silane

Synonyms:tert-Butyl-{(1R,2S)-1-(4-methoxy-benzyloxymethyl)-4-[(2S,5S,6R)-2-methoxy-6-(4-methoxy-benzyloxymethyl)-5-methyl-tetrahydro-pyran-2-yl]-2-methyl-butoxy}-dimethyl-silane

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Chemical Property of tert-Butyl-{(1R,2S)-1-(4-methoxy-benzyloxymethyl)-4-[(2S,5S,6R)-2-methoxy-6-(4-methoxy-benzyloxymethyl)-5-methyl-tetrahydro-pyran-2-yl]-2-methyl-butoxy}-dimethyl-silane

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Technology Process of tert-Butyl-{(1R,2S)-1-(4-methoxy-benzyloxymethyl)-4-[(2S,5S,6R)-2-methoxy-6-(4-methoxy-benzyloxymethyl)-5-methyl-tetrahydro-pyran-2-yl]-2-methyl-butoxy}-dimethyl-silane

There total 14 articles about tert-Butyl-{(1R,2S)-1-(4-methoxy-benzyloxymethyl)-4-[(2S,5S,6R)-2-methoxy-6-(4-methoxy-benzyloxymethyl)-5-methyl-tetrahydro-pyran-2-yl]-2-methyl-butoxy}-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 67-56-1
methanol

: 585526-32-5
(2R,3S,9S,10R)-2-(tert-Butyl-dimethyl-silanyloxy)-1,11-bis-(4-methoxy-benzyloxy)-3,9-dimethyl-10-triethylsilanyloxy-undecan-6-one

: 585526-33-6
tert-Butyl-{(1R,2S)-1-(4-methoxy-benzyloxymethyl)-4-[(2S,5S,6R)-2-methoxy-6-(4-methoxy-benzyloxymethyl)-5-methyl-tetrahydro-pyran-2-yl]-2-methyl-butoxy}-dimethyl-silane

Guidance literature:: With pyridinium p-toluenesulfonate; at 20 ℃;
DOI:10.1016/S0040-4039(03)01184-5

Reference yield:

: 167687-19-6
(2E)-4-[(4-methoxyphenyl)methoxy]-2-methylbut-2-en-1-ol

: 585526-33-6
tert-Butyl-{(1R,2S)-1-(4-methoxy-benzyloxymethyl)-4-[(2S,5S,6R)-2-methoxy-6-(4-methoxy-benzyloxymethyl)-5-methyl-tetrahydro-pyran-2-yl]-2-methyl-butoxy}-dimethyl-silane

Guidance literature:: Multi-step reaction with 10 steps

1.1: (+)-DET; Ti(OiPr)4; tBuOOH / MS-4A / CH₂Cl₂ / -25 °C

2.1: (COCl)2; DMSO / CH₂Cl₂ / -78 °C

3.1: benzene / 20 °C

4.1: 96 percent / Pd₂(dba)3*CHCl₃; n-Bu₃P; HCO₂H / triethylamine; dioxane

5.1: 99 percent / imidazole / dimethylformamide / 0 - 20 °C

6.1: OsO₄; NMO / acetone; H₂O; 2-methyl-propan-2-ol / 20 °C

6.2: Pb(OAc)4 / toluene / 20 °C

7.1: PPh₃; Et₃N / CH₂Cl₂ / 0 - 20 °C

7.2: n-BuLi / tetrahydrofuran / -78 - 20 °C

8.1: 91 percent / LHMDS / tetrahydrofuran / -78 - 20 °C

9.1: 99 percent / H₂ / Pd/C / ethyl acetate / 20 °C

10.1: 95 percent / PPTS / 20 °C

With 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; osmium(VIII) oxide; formic acid; N-methyl-2-indolinone; oxalyl dichloride; diethyl (2R,3R)-tartrate; tributylphosphine; hydrogen; pyridinium p-toluenesulfonate; dimethyl sulfoxide; triethylamine; triphenylphosphine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; triethylamine; N,N-dimethyl-formamide; acetone; tert-butyl alcohol; benzene; 3.1: Wittig reaction;
DOI:10.1016/S0040-4039(03)01184-5

Reference yield:

: 167687-20-9
[3-(4-methoxybenzyloxymethyl)-2-methyloxiranyl]methanol

: 585526-33-6
tert-Butyl-{(1R,2S)-1-(4-methoxy-benzyloxymethyl)-4-[(2S,5S,6R)-2-methoxy-6-(4-methoxy-benzyloxymethyl)-5-methyl-tetrahydro-pyran-2-yl]-2-methyl-butoxy}-dimethyl-silane

Guidance literature:: Multi-step reaction with 9 steps

1.1: (COCl)2; DMSO / CH₂Cl₂ / -78 °C

2.1: benzene / 20 °C

3.1: 96 percent / Pd₂(dba)3*CHCl₃; n-Bu₃P; HCO₂H / triethylamine; dioxane

4.1: 99 percent / imidazole / dimethylformamide / 0 - 20 °C

5.1: OsO₄; NMO / acetone; H₂O; 2-methyl-propan-2-ol / 20 °C

5.2: Pb(OAc)4 / toluene / 20 °C

6.1: PPh₃; Et₃N / CH₂Cl₂ / 0 - 20 °C

6.2: n-BuLi / tetrahydrofuran / -78 - 20 °C

7.1: 91 percent / LHMDS / tetrahydrofuran / -78 - 20 °C

8.1: 99 percent / H₂ / Pd/C / ethyl acetate / 20 °C

9.1: 95 percent / PPTS / 20 °C

With 1H-imidazole; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; osmium(VIII) oxide; formic acid; N-methyl-2-indolinone; oxalyl dichloride; tributylphosphine; hydrogen; pyridinium p-toluenesulfonate; dimethyl sulfoxide; triethylamine; triphenylphosphine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; triethylamine; N,N-dimethyl-formamide; acetone; tert-butyl alcohol; benzene; 2.1: Wittig reaction;
DOI:10.1016/S0040-4039(03)01184-5