(R)-2-methylcarbonyloxy-1-phenylethyl acetate

Base Information

Chemical Name:(R)-2-methylcarbonyloxy-1-phenylethyl acetate
CAS No.:78692-90-7
Molecular Formula:C₁₂H₁₄O₄
Molecular Weight:222.241
Hs Code.:

Synonyms:(R)-2-methylcarbonyloxy-1-phenylethyl acetate

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Chemical Property of (R)-2-methylcarbonyloxy-1-phenylethyl acetate

Chemical Property:

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Technology Process of (R)-2-methylcarbonyloxy-1-phenylethyl acetate

There total 22 articles about (R)-2-methylcarbonyloxy-1-phenylethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6
styrene

: 56021-54-6
iodine triacetate

: 78692-90-7,83023-91-0
(R)-2-methylcarbonyloxy-1-phenylethyl acetate

Guidance literature:: iodine triacetate; With dimethyl 2,2’-(1,3-phenylenebis(oxy))(2R,2’R)-dipropionate; acetic acid; at 20 ℃; for 5h; Schlenk technique; Inert atmosphere;

styrene; With trimethylsilyl acetate; boron trifluoride diethyl etherate; In dichloromethane; at -78 - 20 ℃; for 10h; Reagent/catalyst; stereoselective reaction; Schlenk technique; Inert atmosphere;
DOI:10.1002/anie.201804642

Reference yield: 54.0%

: 100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6
styrene

: 2754-27-0
trimethylsilyl acetate

: 78692-90-7,83023-91-0
(R)-2-methylcarbonyloxy-1-phenylethyl acetate

Guidance literature:: With boron trifluoride diethyl etherate; dimethyl-2,2’-((4-(diacetoxy-λ³-iodanyl)-1,3-phenylene)bis(oxy))(2R,2’R)-dipropionate; acetic acid; In dichloromethane; at -78 - 20 ℃; for 10h; stereoselective reaction; Schlenk technique; Inert atmosphere;
DOI:10.1002/anie.201804642

Reference yield:

: 100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6
styrene

: 108-24-7
acetic anhydride

: 64-19-7,77671-22-8
acetic acid

: 78692-90-7,83023-91-0
(R)-2-methylcarbonyloxy-1-phenylethyl acetate

: 147256-19-7,83023-91-0
(S)-2-methylcarbonyloxy-1-phenylethyl acetate

Guidance literature:: styrene; acetic acid; With trimethylsilyl trifluoromethanesulfonate; (R,R)-1,3-di(1-(1-adamantoxycarbonyl)ethoxy)-2-iodobenzene; Selectfluor; at 20 ℃; for 12h; Sealed tube;

acetic anhydride; With dmap; at 20 ℃; for 5h; Reagent/catalyst; Overall yield = 66 %; Overall yield = 29.4 mg; enantioselective reaction;
DOI:10.1055/s-0035-1561313