trans-N-(1-(4-(methylamino)cyclohexyl)indolin-5-yl)thiophene-2-carboximidamide

Base Information

Chemical Name:trans-N-(1-(4-(methylamino)cyclohexyl)indolin-5-yl)thiophene-2-carboximidamide
CAS No.:1063410-24-1
Molecular Formula:C₂₀H₂₆N₄S
Molecular Weight:354.519
Hs Code.:

Synonyms:trans-N-(1-(4-(methylamino)cyclohexyl)indolin-5-yl)thiophene-2-carboximidamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of trans-N-(1-(4-(methylamino)cyclohexyl)indolin-5-yl)thiophene-2-carboximidamide

Chemical Property:

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Technology Process of trans-N-(1-(4-(methylamino)cyclohexyl)indolin-5-yl)thiophene-2-carboximidamide

There total 10 articles about trans-N-(1-(4-(methylamino)cyclohexyl)indolin-5-yl)thiophene-2-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1063410-20-7
trans-tert-butylmethyl(4-(5-(thiophene-2-carboximidamido)indolin-1-yl)cyclohexyl)carbamate

: 1063410-24-1
trans-N-(1-(4-(methylamino)cyclohexyl)indolin-5-yl)thiophene-2-carboximidamide

Guidance literature:: With hydrogenchloride; In methanol; water; at 20 ℃; Reflux; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.07.006

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1063410-24-1
trans-N-(1-(4-(methylamino)cyclohexyl)indolin-5-yl)thiophene-2-carboximidamide

Guidance literature:: Multi-step reaction with 9 steps

1: sodium cyanoborohydride; acetic acid / 1,2-dichloro-ethane / 20 °C / Inert atmosphere

2: N-Bromosuccinimide / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3: hydrogenchloride / water; acetone / 16 h / 20 °C / Inert atmosphere

4: sodium cyanoborohydride; acetic acid / methanol / 0 - 20 °C / Inert atmosphere

5: triethylamine / 1,4-dioxane / 20 °C / Inert atmosphere

6: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; lithium hexamethyldisilazane / tetrahydrofuran; hexane / 3 h / 20 - 100 °C / Sealed tube; Inert atmosphere

7: tetrabutyl ammonium fluoride / tetrahydrofuran; hexane / 20 °C / Sealed tube; Inert atmosphere

8: ethanol / 20 °C / Inert atmosphere

9: hydrogenchloride / methanol; water / 20 °C / Reflux; Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; tri-tert-butyl phosphine; tetrabutyl ammonium fluoride; sodium cyanoborohydride; acetic acid; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; 6: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.ejmech.2012.07.006

Reference yield:

: 1063410-05-8
1-(1,4-dioxaspiro[4.5]decan-8-yl)indoline

: 1063410-24-1
trans-N-(1-(4-(methylamino)cyclohexyl)indolin-5-yl)thiophene-2-carboximidamide

Guidance literature:: Multi-step reaction with 8 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: hydrogenchloride / water; acetone / 16 h / 20 °C / Inert atmosphere

3: sodium cyanoborohydride; acetic acid / methanol / 0 - 20 °C / Inert atmosphere

4: triethylamine / 1,4-dioxane / 20 °C / Inert atmosphere

5: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; lithium hexamethyldisilazane / tetrahydrofuran; hexane / 3 h / 20 - 100 °C / Sealed tube; Inert atmosphere

6: tetrabutyl ammonium fluoride / tetrahydrofuran; hexane / 20 °C / Sealed tube; Inert atmosphere

7: ethanol / 20 °C / Inert atmosphere

8: hydrogenchloride / methanol; water / 20 °C / Reflux; Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; tri-tert-butyl phosphine; tetrabutyl ammonium fluoride; sodium cyanoborohydride; acetic acid; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; water; N,N-dimethyl-formamide; acetone; 5: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.ejmech.2012.07.006