{(E)-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-phenylethenyl} 2-pyrimidinyl sulfide

Base Information

Chemical Name:{(E)-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-phenylethenyl} 2-pyrimidinyl sulfide
CAS No.:864498-92-0
Molecular Formula:C₂₄H₂₄N₂O₂S
Molecular Weight:404.533
Hs Code.:

Synonyms:{(E)-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-phenylethenyl} 2-pyrimidinyl sulfide

Suppliers and Price of {(E)-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-phenylethenyl} 2-pyrimidinyl sulfide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of {(E)-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-phenylethenyl} 2-pyrimidinyl sulfide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of {(E)-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-phenylethenyl} 2-pyrimidinyl sulfide

There total 3 articles about {(E)-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-phenylethenyl} 2-pyrimidinyl sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 651023-32-4
2-(cyclopentyloxy)-4-iodo-1-methoxybenzene

: 591-50-4
iodobenzene

: 83335-28-8
2-pyrimidinyl vinyl sulfide

: {(Z)-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-phenylethenyl} 2-pyrimidinyl sulfide

: 864498-92-0
{(E)-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-phenylethenyl} 2-pyrimidinyl sulfide

Guidance literature:: iodobenzene; 2-pyrimidinyl vinyl sulfide; With bis(tri-t-butylphosphine)palladium⁽⁰⁾; triethylamine; In toluene; at 60 ℃; for 4h;

2-(cyclopentyloxy)-4-iodo-1-methoxybenzene; In toluene; at 90 ℃; for 18h;
DOI:10.1021/jo0510437

Reference yield:

: 137-43-9
Cyclopentyl bromide

: 864498-92-0
{(E)-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-phenylethenyl} 2-pyrimidinyl sulfide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 81 percent / K₂CO₃ / dimethylformamide / 22 h / 50 °C

2.1: triethylamine; Pd[P(t-Bu)3]2 / toluene / 4 h / 60 °C

2.2: 87 percent / toluene / 18 h / 90 °C

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium carbonate; triethylamine; In N,N-dimethyl-formamide; toluene; 2.1: Mizoroki-Heck arylation / 2.2: Mizoroki-Heck reaction;
DOI:10.1021/jo0510437

Reference yield:

: 160257-85-2
5-iodo-2-methoxyphenol

: 864498-92-0
{(E)-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-phenylethenyl} 2-pyrimidinyl sulfide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 81 percent / K₂CO₃ / dimethylformamide / 22 h / 50 °C

2.1: triethylamine; Pd[P(t-Bu)3]2 / toluene / 4 h / 60 °C

2.2: 87 percent / toluene / 18 h / 90 °C

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium carbonate; triethylamine; In N,N-dimethyl-formamide; toluene; 2.1: Mizoroki-Heck arylation / 2.2: Mizoroki-Heck reaction;
DOI:10.1021/jo0510437