N-[4-(2-thienylmethyleneamino)phenyl]-5-isopropyl-3,8-dimethylazulene-1-sulfonamide

Base Information

Chemical Name:N-[4-(2-thienylmethyleneamino)phenyl]-5-isopropyl-3,8-dimethylazulene-1-sulfonamide
CAS No.:1338351-04-4
Molecular Formula:C₂₆H₂₆N₂O₂S₂
Molecular Weight:462.637
Hs Code.:

Synonyms:N-[4-(2-thienylmethyleneamino)phenyl]-5-isopropyl-3,8-dimethylazulene-1-sulfonamide

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Chemical Property of N-[4-(2-thienylmethyleneamino)phenyl]-5-isopropyl-3,8-dimethylazulene-1-sulfonamide

Chemical Property:

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Technology Process of N-[4-(2-thienylmethyleneamino)phenyl]-5-isopropyl-3,8-dimethylazulene-1-sulfonamide

There total 5 articles about N-[4-(2-thienylmethyleneamino)phenyl]-5-isopropyl-3,8-dimethylazulene-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 98-03-3
thiophene-2-carbaldehyde

: 1338351-00-0
N-(4-aminophenyl)-3,8-dimethyl-5-isopropyl-1-azulene sulfonamide

: 1338351-04-4
N-[4-(2-thienylmethyleneamino)phenyl]-5-isopropyl-3,8-dimethylazulene-1-sulfonamide

Guidance literature:: In ethanol; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2011.08.018

Reference yield:

: 16915-32-5
5-isopropyl-3,8-dimethyl-azulene-1-sulfonic acid

: 1338351-04-4
N-[4-(2-thienylmethyleneamino)phenyl]-5-isopropyl-3,8-dimethylazulene-1-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide

2: pyridine; oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.17 h / Cooling with ice

3: pyridine; triethylamine / dichloromethane / 1 h / 20 °C

4: ethanol / 1 h / 20 °C

With pyridine; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; In ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.08.018

Reference yield:

: 69174-69-2
5-isopropyl-3,8-dimethyl-azulene-1-sulfonyl chloride

: 1338351-04-4
N-[4-(2-thienylmethyleneamino)phenyl]-5-isopropyl-3,8-dimethylazulene-1-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; triethylamine / dichloromethane / 1 h / 20 °C

2: ethanol / 1 h / 20 °C

With pyridine; triethylamine; In ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.08.018