N-(2-fluoro-4-nitrophenyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

Base Information

Chemical Name:N-(2-fluoro-4-nitrophenyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine
CAS No.:1428155-02-5
Molecular Formula:C₁₆H₁₅FN₆O₃
Molecular Weight:358.332
Hs Code.:

Synonyms:N-(2-fluoro-4-nitrophenyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

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Chemical Property of N-(2-fluoro-4-nitrophenyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

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Technology Process of N-(2-fluoro-4-nitrophenyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

There total 1 articles about N-(2-fluoro-4-nitrophenyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 369-35-7
2-fluoro-4-nitroaniline

: 7306-68-5
6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

: 1428155-02-5
N-(2-fluoro-4-nitrophenyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

Guidance literature:: With palladium diacetate; potassium carbonate; XPhos; In water; tert-butyl alcohol; at 110 ℃; for 15h; Inert atmosphere; Sealed tube;
DOI:10.1016/j.ejmech.2012.06.005

Reference yield: 89.0%

: 1428155-02-5
N-(2-fluoro-4-nitrophenyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

: 1428155-04-7
2-fluoro-N₁-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)benzene-1,4-diamine

Guidance literature:: With iron; ammonium chloride; In ethanol; water; at 90 ℃; for 2h;
DOI:10.1016/j.ejmech.2012.06.005

Reference yield:

: 1428155-02-5
N-(2-fluoro-4-nitrophenyl)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

: 1428155-21-8
C₂₈H₂₃F₂N₇O₃

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium chloride; iron / water; ethanol / 2 h / 90 °C

2: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; dichloromethane; water;
DOI:10.1016/j.ejmech.2012.06.005