369-35-7

Basic information

• Product Name: 2-Fluoro-4-nitroaniline
• Synonyms: 2-FLUORO-4-NITRO-PHENYLAMINE;2-FLUORO-4-NITROANILINE;2-Fluoro-4-niroaniline;2-FLUORO-4-NITROANILNE;2-Fluoro-4-nitrobenzenamine;2-Fluoro-4-nitroanil;2-Fluoro-4-nitroaninline;4-Amino-3-fluoronitrobenzene
• CAS NO: 369-35-7
• Molecular Formula: C₆H₅FN₂O₂
• Molecular Weight: 156.11
• EINECS: 206-719-8
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds;Amines;C2 to C6;Nitrogen Compounds;Aniline series
• Mol File: 369-35-7.mol
• Article Data: 10

Chemical Properties

• Melting Point: 126-130°C
• Boiling Point: 317.2 °C at 760 mmHg
• Flash Point: 145.6 °C
• Appearance: /
• Density: 1.448 g/cm³
• Vapor Pressure: 0.000392mmHg at 25°C
• Refractive Index: 1.603
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: -0.45±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 2-Fluoro-4-nitroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-4-nitroaniline(369-35-7)
• EPA Substance Registry System: 2-Fluoro-4-nitroaniline(369-35-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22
• Safety Statements: 36/37
• WGK Germany: 3
• HazardClass: IRRITANT, IRRITANT-HARMFUL
• Hazardous Substances Data: 369-35-7(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

It is used as a pharmaceutical intermediate.

Purification Methods

The aniline forms yellow crystals on recrystallisation from aqueous MeOH or EtOH. The acetyl derivative has m 203-204o (from EtOH). [Wepster & Verkade Recl Trav Chim, Pays Bas 68 86 1949, Beilstein 12 III 1647.]

InChI:InChI=1/C6H5FN2O2/c7-5-3-4(9(10)11)1-2-6(5)8/h1-3H,8H2

Upstream product

• 348-19-6 2'-fluoro-4'-nitroacetanilide 
• 367-11-3 ortho-difluorobenzene 
• 369-34-6 3,4-difluoronitrobenzene 
• 399-31-5 N-(2-fluorophenyl)acetamide 
• 402-67-5 3-fluoro-1-nitrobenzene 
• 348-54-9 2-Fluoroaniline 

Downstream Products

• 350-20-9 2-chloro-6-fluoro-4-nitro-aniline 
• 869335-25-1 N-(2-fluoro-4-nitrophenyl)-1H-pyrrolo[2,3-b]pyridin-4-amine 
• 160984-03-2 N-(4-amino-2-fluorophenyl)-1-cyclohexene-1,2-dicarboximide 
• 1073353-89-5 2-(2-fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 819057-45-9 3-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenylamine 
• 1565857-74-0 (3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)trimethylstannane 
• 1623478-23-8 N-(2-fluoro-4-nitrophenyl)-6,7,8-trimethoxy-2-(pyridin-3-yl)quinazolin-4-amine hydrochloride 
• 1621684-19-2 C₂₂H₂₃FN₄O₄S 
• 1609550-65-3 C₁₉H₁₈FN₅O₅ 
• 1542259-37-9 2-fluoro-4-nitro-N-(3-(tetrahydrofuran-2-yl)propyl)aniline 
• 1542259-33-5 N-(2-(adamantan-1-yl)ethyl)-2-fluoro-4-nitroaniline 
• 1542259-17-5 N-(3-(1H-tetrazol-1-yl)propyl)-2-fluoro-4-nitroaniline 
• 220159-01-3 N-(3-(1H-imidazol-1-yl)propyl)-2-fluoro-4-nitroaniline 
• 1542258-43-4 3-(4-((2-(adamantan-1-yl)ethyl)amino)-3-fluorophenyl)-2,6-dimethylpyrimidin-4(3H)-one 

Relevant articles and documents

Synthesis and Evaluation of Novel 7- and 8-Aminophenoxazinones for the Detection of β-Alanine Aminopeptidase Activity and the Reliable Identification of Pseudomonas aeruginosa in Clinical Samples

A series of novel 8-aminophenoxazin-3-one and 7-aminophenoxazin-3-one chromogens and their corresponding β-alanine derivatives were synthesized and evaluated for their ability to detect β-alanyl aminopeptidase activity in bacteria known to hydrolyze β-ala

A convenient copper-catalyzed direct animation of nitroarenes with 9-alkylhydroxylamines

O-Alkylhydroxylamines, particularly O-methylhydroxylamine, aminate nitroarenes in the presence of a strong base and a copper catalyst to give aminonitroarenes in good yields, ortho- or para-Animation with respect to the nitro group takes place, and in some cases the ortho-aminated product is preferentially obtained. With 3-substituted nitrobenzenes where the substituent has a lone pair of electrons, preferential amination occurs at the 2-position to give the sterically most congested 3c-f, 14 and 22g.

Copper-catalyzed direct amination of nitrobenzenes with O-alkylhydroxylamines

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