369-35-7Relevant academic research and scientific papers
Synthesis and Evaluation of Novel 7- and 8-Aminophenoxazinones for the Detection of β-Alanine Aminopeptidase Activity and the Reliable Identification of Pseudomonas aeruginosa in Clinical Samples
Bedernjak, Alexandre F.,Zaytsev, Andrey V.,Babolat, Michèle,Cellier, Marie,James, Arthur L.,Orenga, Sylvain,Perry, John D.,Groundwater, Paul W.,Anderson, Rosaleen J.
supporting information, p. 4476 - 4487 (2016/06/13)
A series of novel 8-aminophenoxazin-3-one and 7-aminophenoxazin-3-one chromogens and their corresponding β-alanine derivatives were synthesized and evaluated for their ability to detect β-alanyl aminopeptidase activity in bacteria known to hydrolyze β-ala
A convenient copper-catalyzed direct animation of nitroarenes with 9-alkylhydroxylamines
Seko, Shinzo,Miyake, Kunihito,Kavvamura, Norio
, p. 1437 - 1444 (2007/10/03)
O-Alkylhydroxylamines, particularly O-methylhydroxylamine, aminate nitroarenes in the presence of a strong base and a copper catalyst to give aminonitroarenes in good yields, ortho- or para-Animation with respect to the nitro group takes place, and in some cases the ortho-aminated product is preferentially obtained. With 3-substituted nitrobenzenes where the substituent has a lone pair of electrons, preferential amination occurs at the 2-position to give the sterically most congested 3c-f, 14 and 22g.
Nitroarylamines via the Vicarious Nucleophilic Substitution of Hydrogen: Amination, Alkylamination, and Arylamination of Nitroarenes with Sulfenamides
Makosza, Mieczyslaw,Bialecki, Maciej
, p. 4878 - 4888 (2007/10/03)
A new reaction of sulfenamides with electrophilic arenes under basic conditions is described. The σ adducts formed from nitroarenes and the anions of sulfenamides undergo elimination of thiol to produce the corresponding o- and/or p-nitroanilines. This reaction is analogous to the known alkylation and hydroxylation of nitroarenes via the vicarious nucleophilic substitution of hydrogen (VNS). The reaction gives access to a wide range of substituted nitroanilines, nitronaphthylamines, and aminoheterocycles. By means of the reaction with N-alkyl- and N-arylsulfenamides, it is possible to obtain N-alkylnitroanilines and nitrodiarylamines. By varying the structure of sulfenamide and the reaction conditions, particularly the nature and concentration of the base, it is possible to control the orientation of animation.
Preparation and alkylation of regioisomeric tetrahydrophthalimide-substituted indolin-2(3H)-ones
Karp,Condon
, p. 1513 - 1520 (2007/10/02)
A series of novel regioisomeric tetrahydrophthalimide-substituted indolin-2-ones has been prepared via the Sommelet-Hauser type cyclization of appropriately substituted anilines as potential herbicides. The resultant indolin-2-ones were then regioselectively alkylated at N-1 and C-3 to give 1,3,3-trisubstituted indolin-2-ones. The most active series was also prepared by the bis-nitration of m-fluorophenylacetic acid followed by reduction and cyclization to give 6-amino-5-fluoroindolin-2-one. Elaboration to the tetrahydrophthalimide-substituted indolin-2-one was followed by C- and N-alkylation to give the desired compounds.
Herbicidal 3-(1-substituted-quinolin-2-on-7-yl)-1-substituted-6-trifluoromethyluracils
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, (2008/06/13)
Herbicidal compounds, compositions containing them, and a method for controlling weeds by application of the compositions is disclosed. The herbicidal compounds are 3-(1-substituted-quinolin-2-on-7-yl)-1-substituted-6-trifluoromethyluracils and related quinolinyl compounds of the formula STR1 in which R is lower alkyl, lower alkenyl, lower alkynyl, lower haloalkyl, lower cyanoalkyl, lower alkoxy, lower alkoxy lower alkylene, and benzyl; X is hydrogen or halogen; and Y is hydrogen, lower alkyl, lower haloalkyl, halogen, lower alkoxy, lower haloalkoxy, lower alkythio, lower alkoxy lower alkylene, lower alkylthio lower alkylene, and hydroxy.
HETEROCYCLIC SYSTEMS CONTAINING BRIDGEHEAD NITROGEN ATOM: PART LXVI. STUDIES OF ORIENTATION OF CYCLIZATION IN THE SYNTHESIS OF 8-FLUOROTHIAZOLOBENZIMIDAZOL-3(2H)-ONE
Dahiya, Rajinder,Pujari, H. K.
, p. 245 - 256 (2007/10/02)
2-Fluoro-6-nitroaniline, obtained by nitration of 2-fluoroacetanilide, on reduction with Raney nickel and hydrazine hydrate followed by treatment of the resulting diamine with carbon disulphide in situ gives 4-fluorobenzimidazolyl-2-thione.This thione on condensation with chloroacetic acid gives 4-fluorobenzimidazol-2-thiolacetic acid which on cyclization with a mixture of acetic anhydride and pyridine furnished 8-fluorothiazolobenzimidazol-3(2H)-one as revealed by 1H-NMR spectroscopy.The condensation of 4-fluorobenzimidazolyl-2-thione with 1,2-dibromoethane yields 2,3-dihydro-8-fluorothiazolobenzimidazole and sym-bis-(4-fluorobenzimidazol-2-ylmercapto)ethane.
Direct Amination of Nitrobenzenes by Vicarious Nucleophilic Substitution
Katritzky, Alan R.,Laurenzo, Kathleen S.
, p. 5039 - 5040 (2007/10/02)
4-Amino-1,2,4-triazole reacts at 25 deg C with nitrobenzene and some substituted nitrobenzenes in the presence of potassium tert-butoxide in Me2SO to give 4-nitroanilines in good yields.The reaction represents an extension of Makosza's vicarious substitution to a convenient nitrogen nucleophile.
