(S,S)-3,4,5-TRIFLUOROPHENYL-NAS BROMIDE

Base Information

• Chemical Name: (S,S)-3,4,5-TRIFLUOROPHENYL-NAS BROMIDE
• CAS No.: 287384-12-7
• Molecular Formula: Br*C₅₆H₃₄F₆N
• Molecular Weight: 914.787
• Mol file: 287384-12-7.mol

Synonyms:4,4'-Spirobi[4H-dinaphth[2,1-c:1',2'-e]azepinium],3,3',5,5'-tetrahydro-2,6-bis(3,4,5-trifluorophenyl)-, bromide, (11bS,11'bS)-(9CI)

Chemical Property of (S,S)-3,4,5-TRIFLUOROPHENYL-NAS BROMIDE

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 0.00000
• Density: g/cm³
• LogP: 12.30900

Purity/Quality:

98% ^*data from raw suppliers

(S,S)-3,4,5-TRIFLUOROPHENYL-NAS BROMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S,S)-3,4,5-TRIFLUOROPHENYL-NAS BROMIDE

There total 8 articles about (S,S)-3,4,5-TRIFLUOROPHENYL-NAS BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(S)-4,5-dihydro-3H-dinaphtho[2,1-c:1′,2′-e]azepine (97551-09-2) + (S)-3,3'-bis(3,4,5-trifluorophenyl)-2,2'-bis(bromomethyl)-1,1'-binaphthyl → (SS)-3,4,5-trifluorophenyl-NAS bromide (287384-12-7,534570-50-8)

Guidance literature:

With potassium carbonate; In acetonitrile; Heating;

DOI:10.1021/jo030032f

Reference yield: 84.0%

(S)-4,5-dihydro-3H-dinaphtho[2,1-c:1′,2′-e]azepine (97551-09-2) + (S)-3,3'-bis(3,4,5-trifluorophenyl)-2,2'-bis(bromomethyl)-1,1'-binaphthyl → (11bS,11b’S)-2,6-bis(3,4,5-trifluorophenyl)-3,3’,5,5’-tetrahydro-4,4’-spirobi[dinaphtho[2,1-c:1’,2’-e]azepin]-4-ium bromide (287384-12-7,534570-50-8)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 3.5h; Heating / reflux;

Reference yield: 66.0%

(S)-2,6-bis(3,4,5-trifluorophenyl)-4,5-dihydro-3H-dinaphtho[2,1-c:1’,2’-e]azepine + (S)-2,2'-bis(bromomethyl)-1,1'-binaphthyl (37803-02-4) → (11bS,11b’S)-2,6-bis(3,4,5-trifluorophenyl)-3,3’,5,5’-tetrahydro-4,4’-spirobi[dinaphtho[2,1-c:1’,2’-e]azepin]-4-ium bromide (287384-12-7,534570-50-8)

Guidance literature:

With potassium carbonate; In acetonitrile; at 85 - 90 ℃; for 24h; Schlenk technique;

DOI:10.3390/molecules24213844

upstream raw materials:

(S)-4,5-dihydro-3H-dinaphtho[2,1-c:1′,2′-e]azepine

(S)-2,2'-bis(bromomethyl)-1,1'-binaphthyl

3,4,5-trifluorophenylboronic acid