(3aR,6R,7R,7aR)-6-(4-(p-methoxybenzyloxy)but-2-ynyl)-7-(tert-butyldimethylsilyl)oxy-tetrahydro-2,2-dimethyl-3aH-[1,3]dioxolo[4,5-c]pyran

Base Information

Chemical Name:(3aR,6R,7R,7aR)-6-(4-(p-methoxybenzyloxy)but-2-ynyl)-7-(tert-butyldimethylsilyl)oxy-tetrahydro-2,2-dimethyl-3aH-[1,3]dioxolo[4,5-c]pyran
CAS No.:892569-36-7
Molecular Formula:C₂₆H₄₀O₆Si
Molecular Weight:476.686
Hs Code.:

Synonyms:(3aR,6R,7R,7aR)-6-(4-(p-methoxybenzyloxy)but-2-ynyl)-7-(tert-butyldimethylsilyl)oxy-tetrahydro-2,2-dimethyl-3aH-[1,3]dioxolo[4,5-c]pyran

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Chemical Property of (3aR,6R,7R,7aR)-6-(4-(p-methoxybenzyloxy)but-2-ynyl)-7-(tert-butyldimethylsilyl)oxy-tetrahydro-2,2-dimethyl-3aH-[1,3]dioxolo[4,5-c]pyran

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Technology Process of (3aR,6R,7R,7aR)-6-(4-(p-methoxybenzyloxy)but-2-ynyl)-7-(tert-butyldimethylsilyl)oxy-tetrahydro-2,2-dimethyl-3aH-[1,3]dioxolo[4,5-c]pyran

There total 8 articles about (3aR,6R,7R,7aR)-6-(4-(p-methoxybenzyloxy)but-2-ynyl)-7-(tert-butyldimethylsilyl)oxy-tetrahydro-2,2-dimethyl-3aH-[1,3]dioxolo[4,5-c]pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 892569-84-5
Trifluoro-methanesulfonic acid (3aR,6R,7R,7aR)-7-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-ylmethyl ester

: 4039-83-2
3-(4-methoxybenzyloxy)propyne

: 892569-36-7
(3aR,6R,7R,7aR)-6-(4-(p-methoxybenzyloxy)but-2-ynyl)-7-(tert-butyldimethylsilyl)oxy-tetrahydro-2,2-dimethyl-3aH-[1,3]dioxolo[4,5-c]pyran

Guidance literature:: 3-(4-methoxybenzyloxy)propyne; With n-butyllithium; In tetrahydrofuran; hexane; at -65 ℃; for 2h;

Trifluoro-methanesulfonic acid (3aR,6R,7R,7aR)-7-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-ylmethyl ester; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In tetrahydrofuran; hexane; at -65 ℃; for 2.5h;
DOI:10.1021/jo060410r

Reference yield:

: 892569-32-3
(3aR,6R,7R,7aR)-tetrahydro-(7-(tert-butyldimethylsilyl)oxy-2,2-dimethyl-3aH-[1,3]dioxolo[4,5-c]pyran-6-yl)methanol

: 892569-36-7
(3aR,6R,7R,7aR)-6-(4-(p-methoxybenzyloxy)but-2-ynyl)-7-(tert-butyldimethylsilyl)oxy-tetrahydro-2,2-dimethyl-3aH-[1,3]dioxolo[4,5-c]pyran

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,6-lutidine / CH₂Cl₂ / 2 h / -65 °C

2.1: n-Buli / tetrahydrofuran; hexane / 2 h / -65 °C

2.2: 36.0 g / DMPU / tetrahydrofuran; hexane / 2.5 h / -65 °C

With 2,6-dimethylpyridine; n-butyllithium; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo060410r

Reference yield:

: 892569-24-3
3-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-3,6-dihydro-2H-pyran

: 892569-36-7
(3aR,6R,7R,7aR)-6-(4-(p-methoxybenzyloxy)but-2-ynyl)-7-(tert-butyldimethylsilyl)oxy-tetrahydro-2,2-dimethyl-3aH-[1,3]dioxolo[4,5-c]pyran

Guidance literature:: Multi-step reaction with 5 steps

1.1: OsO₄; N-methylmorpholine oxide / H₂O; acetone / 15 h

2.1: TsOH*H₂O / CH₂Cl₂ / 4 h / 0 °C

3.1: 45.0 g / MeOH / 10 h / 20 °C

4.1: 2,6-lutidine / CH₂Cl₂ / 2 h / -65 °C

5.1: n-Buli / tetrahydrofuran; hexane / 2 h / -65 °C

5.2: 36.0 g / DMPU / tetrahydrofuran; hexane / 2.5 h / -65 °C

With 2,6-dimethylpyridine; methanol; osmium(VIII) oxide; n-butyllithium; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; In tetrahydrofuran; hexane; dichloromethane; water; acetone;
DOI:10.1021/jo060410r