2-(3,4,5-Trimethoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

Base Information

• Chemical Name: 2-(3,4,5-Trimethoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one
• CAS No.: 13165-12-3
• Molecular Formula: C₁₇H₁₈N₂O₄
• Molecular Weight: 314.341
• European Community (EC) Number: 653-575-0
• Nikkaji Number: J2.937.965C
• Mol file: 13165-12-3.mol

Synonyms:2-(3,4,5-Trimethoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one;13165-12-3;Oprea1_541970;2-(3,4,5-trimethoxyphenyl)-2,3-dihydro-1H-quinazolin-4-one;MFCD00086807;AKOS002265648;AKOS016314864;AB00682541-01;Z48978324;2-(3,4,5-trimethoxyphenyl)-2,3-dihydro-4(1H)-quinazolinone;2-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydroquinazolin-4-one

Chemical Property of 2-(3,4,5-Trimethoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

Chemical Property:

• XLogP3: 2.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 314.12665706
• Heavy Atom Count: 23
• Complexity: 405

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1OC)OC)C2NC3=CC=CC=C3C(=O)N2

Technology Process of 2-(3,4,5-Trimethoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

There total 3 articles about 2-(3,4,5-Trimethoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3,4,5-trimethoxy-benzaldehyde (86-81-7) + anthranilic acid amide (28144-70-9,88-68-6) → 2-(3,4,5-trimethoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one (13165-12-3)

Guidance literature:

With antimony(III) chloride; In methanol; at 20 ℃; for 0.3h;

DOI:10.1016/j.jpcs.2017.03.008

Reference yield: 95.0%

isatoic anhydride (118-48-9) + 3,4,5-trimethoxy-benzaldehyde (86-81-7) → 2-(3,4,5-trimethoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one (13165-12-3)

Guidance literature:

With titanium silicon oxide; ammonium acetate; In water; at 100 ℃; for 2h; Green chemistry;

DOI:10.1080/00397911.2016.1254801

Reference yield:

→ 2-(3,4,5-trimethoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one (13165-12-3)

Guidance literature:

2-<3.4.5-Trimethoxy-benzylidenamino>-benzamid, wss. HCl, Δ;

upstream raw materials:

3,4,5-trimethoxy-benzaldehyde

anthranilic acid amide

isatoic anhydride

Downstream raw materials:

6-chloro-2-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one