6-chloro-2-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

Base Information

• Chemical Name: 6-chloro-2-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one
• CAS No.: 21878-28-4
• Molecular Formula: C₁₇H₁₆N₂O₄
• Molecular Weight: 312.325
• Mol file: 21878-28-4.mol

Synonyms:6-chloro-2-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

Chemical Property of 6-chloro-2-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-chloro-2-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

There total 18 articles about 6-chloro-2-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3,4,5-trimethoxy-benzaldehyde (86-81-7) + anthranilic acid amide (28144-70-9,88-68-6) → 6-chloro-2-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one (21878-28-4)

Guidance literature:

With copper(II) choride dihydrate; In ethanol; for 16h; Reflux;

DOI:10.1016/j.bmc.2014.04.039

Reference yield: 99.0%

→ 6-chloro-2-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one (21878-28-4)

Guidance literature:

With copper(II) choride dihydrate; In ethanol; for 16h; Reflux;

Reference yield: 95.0%

2-(3,4,5-trimethoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one (13165-12-3) → 6-chloro-2-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one (21878-28-4)

Guidance literature:

With oxygen; hydroquinone; In tetrahydrofuran; aq. phosphate buffer; at 40 ℃; for 20h; pH=4.5; Green chemistry;

DOI:10.1016/j.jcat.2019.12.023

upstream raw materials:

N-(3,4,5-trimethoxy-benzoyl)-anthranilic acid methyl ester

3,4,5-trimethoxy-benzaldehyde

anthranilic acid amide

3,4,5-Trimethoxybenzoyl chloride