N-<α-(2-bromobenzyl)-3,4-methylenedioxybenzyl>-N-methylaminoacetaldehyde diethyl acetal

Base Information

Chemical Name:N-<α-(2-bromobenzyl)-3,4-methylenedioxybenzyl>-N-methylaminoacetaldehyde diethyl acetal
CAS No.:81396-92-1
Molecular Formula:C₂₂H₂₈BrNO₄
Molecular Weight:450.373
Hs Code.:

Synonyms:N-<α-(2-bromobenzyl)-3,4-methylenedioxybenzyl>-N-methylaminoacetaldehyde diethyl acetal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<α-(2-bromobenzyl)-3,4-methylenedioxybenzyl>-N-methylaminoacetaldehyde diethyl acetal

Chemical Property:

Purity/Quality:

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Technology Process of N-<α-(2-bromobenzyl)-3,4-methylenedioxybenzyl>-N-methylaminoacetaldehyde diethyl acetal

There total 6 articles about N-<α-(2-bromobenzyl)-3,4-methylenedioxybenzyl>-N-methylaminoacetaldehyde diethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 81396-91-0
acetaldehyde diethyl acetal

: 81396-92-1
N-<α-(2-bromobenzyl)-3,4-methylenedioxybenzyl>-N-methylaminoacetaldehyde diethyl acetal

Guidance literature:: With formic acid; In N,N-dimethyl-formamide; for 2.5h;
DOI:10.1021/jo00388a053

Reference yield:

: 274-09-9
Methylenedioxybenzene

: 81396-92-1
N-<α-(2-bromobenzyl)-3,4-methylenedioxybenzyl>-N-methylaminoacetaldehyde diethyl acetal

Guidance literature:: Multi-step reaction with 4 steps

1: 90.2 percent / anhyd. aluminium chloride / CH₂Cl₂ / 2 h / -50 - -40 °C

2: titanium tetrachloride / benzene / 1.) 0-5 deg C, 30 min; 2.) room temp., 3 d

3: NaBH₄ / methanol / 3 h / Ambient temperature

4: 2.) NaBH₄ / 1.) MeOH, room temp., 1 h; 2.) MeOH, room temp., 1 h

With sodium tetrahydroborate; aluminium trichloride; titanium tetrachloride; In methanol; dichloromethane; benzene;
DOI:10.1248/cpb.30.4283

Reference yield:

: 55116-09-1
2-bromophenylacetyl chloride

: 81396-92-1
N-<α-(2-bromobenzyl)-3,4-methylenedioxybenzyl>-N-methylaminoacetaldehyde diethyl acetal

Guidance literature:: Multi-step reaction with 4 steps

1: 90.2 percent / anhyd. aluminium chloride / CH₂Cl₂ / 2 h / -50 - -40 °C

2: titanium tetrachloride / benzene / 1.) 0-5 deg C, 30 min; 2.) room temp., 3 d

3: NaBH₄ / methanol / 3 h / Ambient temperature

4: 2.) NaBH₄ / 1.) MeOH, room temp., 1 h; 2.) MeOH, room temp., 1 h

With sodium tetrahydroborate; aluminium trichloride; titanium tetrachloride; In methanol; dichloromethane; benzene;
DOI:10.1248/cpb.30.4283