6-iodo-9-[2,3,5-tri-O-(2,4,6-trimethylbenzoyl)-β-D-ribofuranosyl]purine

Base Information

Chemical Name:6-iodo-9-[2,3,5-tri-O-(2,4,6-trimethylbenzoyl)-β-D-ribofuranosyl]purine
CAS No.:756494-08-3
Molecular Formula:C₄₀H₄₁IN₄O₇
Molecular Weight:816.693
Hs Code.:

Synonyms:6-iodo-9-[2,3,5-tri-O-(2,4,6-trimethylbenzoyl)-β-D-ribofuranosyl]purine

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Chemical Property of 6-iodo-9-[2,3,5-tri-O-(2,4,6-trimethylbenzoyl)-β-D-ribofuranosyl]purine

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Technology Process of 6-iodo-9-[2,3,5-tri-O-(2,4,6-trimethylbenzoyl)-β-D-ribofuranosyl]purine

There total 4 articles about 6-iodo-9-[2,3,5-tri-O-(2,4,6-trimethylbenzoyl)-β-D-ribofuranosyl]purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 756494-07-2
6-chloro-9-[2,3,5-tri-O-(2,4,6-trimethylbenzoyl)-β-D-ribofuranosyl]purine

: 756494-08-3
6-iodo-9-[2,3,5-tri-O-(2,4,6-trimethylbenzoyl)-β-D-ribofuranosyl]purine

Guidance literature:: With trifluoroacetic acid; sodium iodide; In butanone; at -50 - -40 ℃; for 5h;
DOI:10.1021/ol048987n

Reference yield:

: 756494-06-1
2',3',5'-tri-O-(2,4,6-trimethylbenzoyl)inosine

: 756494-08-3
6-iodo-9-[2,3,5-tri-O-(2,4,6-trimethylbenzoyl)-β-D-ribofuranosyl]purine

Guidance literature:: Multi-step reaction with 2 steps

1: POCl₃; N,N-dimethylaniline / acetonitrile / Heating

2: NaI / butan-2-one / 2 h / -40 °C

With N,N-dimethyl-aniline; sodium iodide; trichlorophosphate; In acetonitrile; butanone; 2: Finkelstein reaction;
DOI:10.1021/ja070021u

Reference yield:

: 480-63-7
mesitylenecarboxylic acid

: 756494-08-3
6-iodo-9-[2,3,5-tri-O-(2,4,6-trimethylbenzoyl)-β-D-ribofuranosyl]purine

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / TFAA / CH₂Cl₂ / 4 h / 0 °C

2: 87 percent / POCl₃; benzyltriethylammonium chloride; N,N-dimethylaniline / acetonitrile / 0.17 h / 80 °C

3: 73 percent / NaI; TFA / butan-2-one / 5 h / -50 - -40 °C

With N-benzyl-N,N,N-triethylammonium chloride; N,N-dimethyl-aniline; trifluoroacetic acid; trifluoroacetic anhydride; sodium iodide; trichlorophosphate; In dichloromethane; acetonitrile; butanone; 3: Finkelstein reaction;
DOI:10.1021/ol048987n