480-63-7

Usage

Uses

Used in Chemical Industry:
2,4,6-Trimethylbenzoic acid is used as an intermediate in the synthesis of various organic compounds, such as dyes, pharmaceuticals, and other specialty chemicals, due to its unique chemical structure and reactivity.
Used in Antioxidant Applications:
2,4,6-Trimethylbenzoic acid is used as an antioxidant in the chemical and pharmaceutical industries to prevent the oxidation of sensitive compounds, thereby extending their shelf life and maintaining their stability.
Used in Pharmaceutical Industry:
2,4,6-Trimethylbenzoic acid is used as a building block for the development of new drugs, particularly in the synthesis of various pharmaceutical compounds that target specific biological pathways.
Used in Cosmetics Industry:
2,4,6-Trimethylbenzoic acid can be used as an additive in the cosmetics industry, where its antioxidant properties can help protect formulations from oxidative degradation, ensuring their efficacy and stability over time.

Synthesis Reference(s)

Journal of the American Chemical Society, 96, p. 590, 1974 DOI: 10.1021/ja00809a049Organic Syntheses, Coll. Vol. 3, p. 553, 1955Tetrahedron Letters, 11, p. 4459, 1970

Purification Methods

Crystallise mesitoic acid from water, ligroin or carbon tetrachloride [Ohwada et al. J Am Chem Soc 108 3029 1986]. [Beilstein 9 H 553, 9 I 214, 9 II 360, 9 III 2489, 9 IV 1854.]

InChI:InChI=1/C10H12O2/c1-6-4-7(2)9(10(11)12)8(3)5-6/h4-5H,1-3H3,(H,11,12)/p-1

Synthetic route

carbon dioxide (124-38-9) + 1,3,5-trimethyl-benzene (108-67-8) → mesitylenecarboxylic acid (480-63-7)

Conditions	Yield
With Et3SiB(C6F5)4 at 20℃; under 22502.3 Torr; for 18h; Reagent/catalyst;	100%
With aluminum tri-bromide; Triphenylsilyl chloride at 20℃; under 22502.3 Torr; for 3h; Autoclave;	97%
With aluminum (III) chloride at 30℃; under 15001.5 Torr; for 5h; Pressure; Temperature;	95.2%

carbon dioxide (124-38-9) + 2-mesitylmagnesium bromide (2633-66-1) → mesitylenecarboxylic acid (480-63-7)

Conditions	Yield
Stage #1: carbon dioxide; 2-mesitylmagnesium bromide In tetrahydrofuran at 20℃; under 3000.3 Torr; gas-liquid flow reactor assembly; Stage #2: With polymer-supported sulfonic acid In tetrahydrofuran	100%
In tetrahydrofuran at 1℃; for 0.0833333h;	74%

2,4,6-trimethyl-benzoic acid-anhydride (5745-51-7) → 2,4,6-trimethylbenzyl alcohol (4170-90-5) + mesitylenecarboxylic acid (480-63-7)

Conditions	Yield
With Li(1+)*C12H28AlO3(1-) In tetrahydrofuran; hexane at -78℃; for 1h;	A 99% B 98%

mesytaldehyde (487-68-3) → mesitylenecarboxylic acid (480-63-7)

Conditions	Yield
With C4H11FeMo6NO24(3-)*3C16H36N(1+); water; oxygen; sodium carbonate at 50℃; under 760.051 Torr; for 8h; Green chemistry;	99%
With 4H3N*4H(1+)*CuMo6O18(OH)6(4-); water; oxygen; sodium carbonate at 50℃; under 760.051 Torr; for 12h;	99%
With tris[2-(4,6-difluorophenyl)pyridinato-C2,N]-iridium(III); oxygen In acetonitrile at 20℃; Irradiation; Sealed tube; Green chemistry; chemoselective reaction;	90%

2,4,6-trimethylbenzyl alcohol (4170-90-5) → mesitylenecarboxylic acid (480-63-7)

Conditions	Yield
With dihydrogen peroxide In water; toluene at 20 - 85℃; for 4h;	98%
With diethylene glycol dimethyl ether at 70℃; for 0.5h; Sonication;	93%
With potassium phosphate; carbon dioxide; CrH6Mo6O24(3-)*3H3N*3H(1+) In dimethyl sulfoxide at 80℃; under 750.075 Torr; for 24h; Green chemistry;	84%

carbon dioxide (124-38-9) + 2,4,6-trimethylbenzeneboronic acid neopentyl glycol cyclic ester (214360-78-8) → mesitylenecarboxylic acid (480-63-7)

Conditions	Yield
With potassium tert-butylate; copper(l) chloride; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride In tetrahydrofuran at 70℃; under 760.051 Torr; for 24h;	98%

methyl 2,4,6-trimethylbenzoate (2282-84-0) → mesitylenecarboxylic acid (480-63-7)

Conditions	Yield
With tetra(n-butyl)ammonium hydroxide In tetrahydrofuran; water at 70℃; for 1h;	97%
With potassium hydroxide; Aliquat 336 at 200℃; for 0.0833333h; microwave irradiation;	95%
With Me2AlTeMe In toluene at 23℃; for 6h;	91%

n-octyl mesitoate (99921-94-5) → mesitylenecarboxylic acid (480-63-7)

Conditions	Yield
With sodium hydroxide; Aliquat 336 at 200℃; for 0.0833333h; microwave irradiation;	97%

Trichloroacetyl chloride (76-02-8) + 1,3,5-trimethyl-benzene (108-67-8) → mesitylenecarboxylic acid (480-63-7)

Conditions	Yield
Stage #1: trifluoroacetyl chloride; 1,3,5-trimethyl-benzene With aluminum (III) chloride at 0 - 10℃; for 2h; Inert atmosphere; Stage #2: With hydrogenchloride In water Temperature;	95%

C26H30O2Si → mesitylenecarboxylic acid (480-63-7)

Conditions	Yield
With water; N,N-dimethyl-formamide at 70℃; for 3h; Green chemistry; chemoselective reaction;	94%
With N,N,N',N'-tetramethylguanidine In acetonitrile at 50℃; for 1h;	92%

formic acid (64-18-6) + 1,3,5-trimethyl-benzene (108-67-8) → mesitylenecarboxylic acid (480-63-7)

Conditions	Yield
With dipotassium peroxodisulfate; (4-CH3O-C6H4-N-CH2)2PO3SCF3; palladium(II) trifluoroacetate In trifluoroacetic acid at 30℃; for 48h;	93%

C19H32O2Si → mesitylenecarboxylic acid (480-63-7)

Conditions	Yield
With water; N,N-dimethyl-formamide at 70℃; for 3h; Green chemistry; chemoselective reaction;	93%

2,4,6-trimethyl-benzoic acid 2-trimethylsilanyl-ethyl ester → mesitylenecarboxylic acid (480-63-7)

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 20℃;	92%

methyl 2,4,6-trimethylbenzoate (2282-84-0) + diphenyl diselenide (1666-13-3) → mesitylenecarboxylic acid (480-63-7) + selenoanisole (4346-64-9)

Conditions	Yield
Stage #1: diphenyl diselenide With aluminum (III) chloride; zinc In acetonitrile at 70℃; under 760.051 Torr; for 1.25h; Neutral; Stage #2: methyl 2,4,6-trimethylbenzoate In acetonitrile at 70℃; under 760.051 Torr; for 6h; Neutral;	A 92% B n/a

allyl 2,4,6-trimethylbenzoate (2000-88-6) → mesitylenecarboxylic acid (480-63-7)

Conditions	Yield
With Me2AlTeMe In toluene at 23℃; for 12h;	89%
With dichloro bis(acetonitrile) palladium(II); cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate; diethylene glycol dimethyl ether; 1,6-bis(diphenylphosphino)hexane; water In 1,2-dimethoxyethane; dichloromethane at 20 - 85℃; for 1.33333h; Inert atmosphere;	26 %Chromat.

iodomesitylene (4028-63-1) + carbon dioxide (124-38-9) → mesitylenecarboxylic acid (480-63-7)

Conditions	Yield
With C26H30B10Cl2P2Pd In toluene at 80℃; under 760.051 Torr; for 8h;	89%
With copper(l) iodide; diethylzinc; N,N`-dimethylethylenediamine In dimethyl sulfoxide at 25℃; under 760.051 Torr;	61%

carbon dioxide (124-38-9) + 1,3,5-trimethyl-benzene (108-67-8) → mesitylenecarboxylic acid (480-63-7) + dimesityl ketone (5623-45-0)

Conditions	Yield
With chloro-trimethyl-silane; aluminum tri-bromide at 20℃; under 22501.8 Torr; for 3h;	A 87% B 6%
With chloro-trimethyl-silane; aluminum tri-bromide at 20℃; under 22502.3 Torr; for 3h; Autoclave;	A 87% B 6%
With Et3SiB(C6F5)4 at 20℃; under 22502.3 Torr; for 18h; Reagent/catalyst; Friedel-Crafts Acylation;	A 86% B 14%
With aluminum tri-bromide under 44130.5 Torr;

benzyl 2,4,6-trimethylbenzoate (4909-77-7) → mesitylenecarboxylic acid (480-63-7)

Conditions	Yield
With Me2AlTeMe In toluene at 23℃; for 14h;	87%
With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate at 20℃; for 0.25h; chemoselective reaction;	85%

sodium methyl carbonate (6482-39-9) + 2-mesitylmagnesium bromide (2633-66-1) → mesitylenecarboxylic acid (480-63-7)

Conditions	Yield
In diethyl ether at 20℃; for 24h; Inert atmosphere;	85%

carbon dioxide (124-38-9) + 2,4,6-trimethylbenzenesulfonate sodium salt (6148-75-0) → mesitylenecarboxylic acid (480-63-7)

Conditions	Yield
Stage #1: carbon dioxide; 2,4,6-trimethylbenzenesulfonate sodium salt With copper(l) iodide; potassium tert-butylate; o-phenanthroline In dimethyl sulfoxide at 140℃; under 760.051 Torr; for 12h; Schlenk technique; Stage #2: With hydrogenchloride In water; dimethyl sulfoxide Schlenk technique;	82%

carbon dioxide (124-38-9) + sodium 2,4,6-trimethylbenzenesulfinic acid (50827-54-8) → mesitylenecarboxylic acid (480-63-7)

Conditions	Yield
With copper(l) iodide; 1,10-Phenanthroline; potassium tert-butylate In dimethyl sulfoxide at 140℃; under 750.075 Torr; for 3h; Schlenk technique; Sealed tube;	82%

1-mesityl-5-phenyl-6,7,8-trioxabicyclo<3.2.1>octane → 4-hydroxy-1-phenyl-butan-1-one (39755-03-8) + mesitylenecarboxylic acid (480-63-7) + butyrophenone (495-40-9) + 3,4-dihydronaphthalene-1(2H)-one (529-34-0)

Conditions	Yield
With iron(II) sulfate In tetrahydrofuran; water at 20℃; for 16h;	A 9% B 81% C 26% D 13%

1,2,3,4-tetrahydro-1-naphthyl ester of 2,4,6-trimethylbenzoic acid → mesitylenecarboxylic acid (480-63-7)

Conditions	Yield
With chloro-trimethyl-silane; sodium iodide In acetonitrile at 20℃; for 1h; Substitution;	80%

2,4,6-Trimethylacetophenone (1667-01-2) → mesitylenecarboxylic acid (480-63-7)

Conditions	Yield
With oxygen; manganese (II) acetate tetrahydrate; cobalt(II) diacetate tetrahydrate In acetic acid at 100℃; under 760.051 Torr; for 15h;	78%
With permanganate(VII) ion anschl. Behandeln mit Schwefelsaeure;
Multi-step reaction with 2 steps 1: KMnO4; alkali 2: bei der Destillation View Scheme

carbon dioxide (124-38-9) + 2,4,6-trimethylphenyl trifluoromethanesulfonate (125261-32-7) → mesitylenecarboxylic acid (480-63-7)

Conditions	Yield
Stage #1: carbon dioxide; 2,4,6-trimethylphenyl trifluoromethanesulfonate With manganese; [Co(2,9-dimethyl-1,10-phenanthroline)I2] In N,N-dimethyl acetamide at 40℃; under 760.051 Torr; for 20h; Schlenk technique; Stage #2: With hydrogenchloride In diethyl ether; water at 20℃; for 0.166667h; Temperature; Reagent/catalyst; Schlenk technique;	77%
With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; DavePhos In N,N-dimethyl acetamide at 20℃; for 36h; Irradiation; Green chemistry; chemoselective reaction;	75%
With (2’,4’,6’-triisopropyl-[1,1’-biphenyl]-2-yl)-diphenylphosphine; bis(2-phenylpyridinato)(2,2'-bipyridine)iridium(III) hexafluorophosphate; tetrabutylammomium bromide; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide at 20℃; under 760.051 Torr; for 4h; Irradiation;

[(3R,4S)-2-(4-Nitro-phenyl)-5-phenyl-4-(2,4,6-trimethyl-benzoyl)-3,4-dihydro-2H-pyrazol-3-yl]-(2,4,6-trimethyl-phenyl)-methanone (78830-35-0) → mesitylenecarboxylic acid (480-63-7) + [1-(4-Nitro-phenyl)-3-phenyl-1H-pyrazol-4-yl]-(2,4,6-trimethyl-phenyl)-methanone (78830-48-5)

Conditions	Yield
at 200℃; for 0.166667h;	A 65% B 75%

C18H20O2 → mesitylenecarboxylic acid (480-63-7) + 4-methoxybenzoic acid (100-09-4)

Conditions	Yield
With oxygen; potassium hydroxide at 20℃; Schlenk technique; chemoselective reaction;	A 62% B 63%

[(3R,4S)-2,5-Di-p-tolyl-4-(2,4,6-trimethyl-benzoyl)-3,4-dihydro-2H-pyrazol-3-yl]-(2,4,6-trimethyl-phenyl)-methanone (78830-39-4) → mesitylenecarboxylic acid (480-63-7) + (1,3-Di-p-tolyl-1H-pyrazol-4-yl)-(2,4,6-trimethyl-phenyl)-methanone (78830-51-0)

Conditions	Yield
at 200℃; for 0.166667h;	A 30% B 55%

2-(2,4,6-trimethylphenyl)-2-hydroxyacetonitrile (49685-65-6) → mesytaldehyde (487-68-3) + mesitylenecarboxylic acid (480-63-7)

Conditions	Yield
Stage #1: 2-hydroxy-2-(2,4,6-trimethylphenyl)acetonitrile With (η(6)-benzene)chloro[1,2-bis(diphenylphosphino)ethane]ruthenium(II) chloride In benzene at 120℃; for 24h; Inert atmosphere; Schlenk technique; Stage #2: With water In dichloromethane; ethyl acetate; benzene for 24h;	A 40% B 55%

diazomethane (186581-53-3, 908094-01-9) + mesitylenecarboxylic acid (480-63-7) → methyl 2,4,6-trimethylbenzoate (2282-84-0)

Conditions	Yield
In diethyl ether	100%
With diethyl ether

methanol (67-56-1) + mesitylenecarboxylic acid (480-63-7) → methyl 2,4,6-trimethylbenzoate (2282-84-0)

Conditions	Yield
With sulfuric acid at 148 - 159℃; under 9375.7 Torr; for 0.0866667h; Irradiation;	100%
With dmap; dicyclohexyl-carbodiimide
With fluorosulphonic acid at -70℃; Yield given;
With sulfuric acid at 20℃; for 48h;
With sulfuric acid at 100℃; for 24h;

mesitylenecarboxylic acid (480-63-7) + ethyl iodide (75-03-6) → ethyl 2,4,6-trimethylbenzoate (1754-55-8)

Conditions	Yield
With caesium carbonate In acetonitrile for 2h; Heating;	100%
With cesium fluoride In acetonitrile for 1h; Heating;	99%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In benzene
With potassium carbonate In acetone for 16h; Heating;
With cesium fluoride In N,N-dimethyl-formamide at 10 - 15℃; for 24h;	88 % Chromat.

mesitylenecarboxylic acid (480-63-7) + methyl 6'-O-butyryl-β-lactoside (141484-96-0) → methyl 6'-O-butyryl-2,2',3,3',4',6-hexa-O-mesitoyl-β-lactoside (141485-04-3)

Conditions	Yield
With trifluoroacetic anhydride In benzene for 2h; Ambient temperature;	100%

mesitylenecarboxylic acid (480-63-7) + aniline (62-53-3) → 2,4,6-trimethyl-N-phenylbenzamide (5215-40-7)

Conditions	Yield
With diphosphorus tetraiodide In tetrachloromethane; dichloromethane Heating;	100%
With ethylene dichloride hydrochloride; triethylamine In dichloromethane at 0 - 20℃; for 6h;

mesitylenecarboxylic acid (480-63-7) → potassium 2,4,6-trimethylbenzoate

Conditions	Yield
With potassium tert-butylate In methanol at 20℃; for 4h;	100%
With potassium tert-butylate In methanol for 4h;	82%

2-iodo-propane (75-30-9) + mesitylenecarboxylic acid (480-63-7) → isopropyl 2,4,6-trimethylbenzoate (41589-61-1)

Conditions	Yield
With N(Et)4(1+)*(2-pyrrolidone-anion) In N,N-dimethyl-formamide for 1h; Ambient temperature;	99%
With caesium carbonate In acetonitrile for 2h; Heating;	96%
With potassium carbonate In acetone for 16h; Heating;

dichloromethane (75-09-2) + mesitylenecarboxylic acid (480-63-7) → Methylendi-<2,4,6-trimethylbenzoesaeure>-ester (56741-13-0)

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 130℃; for 5h;	99%
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate

styrene (292638-84-7) + mesitylenecarboxylic acid (480-63-7) → (E)-2,4,6-trimethylstilbene (17024-58-7)

Conditions	Yield
With silver carbonate; palladium(II) trifluoroacetate In dimethyl sulfoxide; N,N-dimethyl-formamide at 120℃; for 1.5h; Heck olefination;	99%

mesitylenecarboxylic acid (480-63-7) + poly(styrene-co-divinylbenzene)-supported methyl sulfonate, loading rate of SO3Me: ca. 4.0 mmol/g → methyl 2,4,6-trimethylbenzoate (2282-84-0)

Conditions	Yield
With potassium carbonate In acetonitrile for 4h; Heating;	99%

mesitylenecarboxylic acid (480-63-7) + trimethylaluminum (75-24-1) → [Me2Al(μ-2,4,6-trimethylbenzoate)]2 (884337-83-1)

Conditions	Yield
In hexane byproducts: CH4; in a glovebox, Al-contg. compd. (2.00 mmol) was slowly added to a cooledhexane suspn. (-35.degree C) of carboxylic acid (2.00 mmol); stirring a t ambient temp. for 3 h; the solvent was removed in vac.; elem. anal.;	99%

[RhCl2(p-cymene)]2 + mesitylenecarboxylic acid (480-63-7) → Ru(mesitylCO2)2(p-cymene)

Conditions	Yield
With potassium carbonate In toluene at 20℃; for 2h; Inert atmosphere;	99%

mesitylenecarboxylic acid (480-63-7) + N-(2-methylbenzoyl)-8-aminoquinoline (1182669-71-1) → 3-methyl-2-(quinolin-8-ylcarbamoyl)phenyl 2,4,6-trimethylbenzoate

Conditions	Yield
With cobalt(II) acetate; sodium carbonate; silver sulfate In 1,2-dichloro-ethane at 80℃; for 24h; Inert atmosphere; Sealed tube; regioselective reaction;	99%

mesitylenecarboxylic acid (480-63-7) + aniline (62-53-3) → N-(2,4,6-trimethylphenyl)-N'-phenylurea (2904-67-8)

Conditions	Yield
With diphenyl phosphoryl azide; triethylamine In toluene at 100℃; for 0.0166667h; Curtius Rearrangement; Microwave irradiation;	99%

mesitylenecarboxylic acid (480-63-7) + 1,2-diamino-benzene (95-54-5) → 2-(2,4,6-trimethylphenyl)-1H-benzoimidazole (36677-31-3)

Conditions	Yield
With Eaton’s reagent at 140℃; for 0.5h; Inert atmosphere;	98.6%
With Eaton′s Reagent at 120 - 140℃; for 0.5h; Inert atmosphere;	98.6%
With polyphosphoric acid at 200℃; for 2h;	80%
With polyphosphoric acid at 120 - 150℃; for 16h;	62%

ethyl bromide (74-96-4) + mesitylenecarboxylic acid (480-63-7) → ethyl 2,4,6-trimethylbenzoate (1754-55-8)

Conditions	Yield
With potassium hydroxide; Aliquat 336 at 60℃; for 1h;	98%
With potassium carbonate In acetone at 100℃; for 0.166667h; microwave irradiation;	94%
With tetradecyl(trihexyl)phosphonium bistriflamide; N-ethyl-N,N-diisopropylamine at 30℃;	86%

mesitylenecarboxylic acid (480-63-7) + benzylamine (100-46-9) → N-benzyl-2,4,6-trimethylbenzamide (104385-10-6)

Conditions	Yield
With TEA; diphenyl (2,3-dihydro-2-thioxo-3-benzoxazolyl)phosphonate In various solvent(s) for 2h; Ambient temperature;	98%
With 1-methyl-pyrrolidin-2-one; 3,3'-(phenylphosphinylidene)bis<2(3H)-benzothiazolone; triethylamine Ambient temperature;	91%

mesitylenecarboxylic acid (480-63-7) + benzyl alcohol (100-51-6) → benzyl 2,4,6-trimethylbenzoate (4909-77-7)

Conditions	Yield
With pyridine at 115℃; for 0.5h;	98%

mesitylenecarboxylic acid (480-63-7) + methyl iodide (74-88-4) → methyl 2,4,6-trimethylbenzoate (2282-84-0)

Conditions	Yield
With potassium hydroxide; Aliquat 336 at 20℃; for 1h;	98%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere;	88%

mesitylenecarboxylic acid (480-63-7) + allyl bromide (106-95-6) → allyl 2,4,6-trimethylbenzoate (2000-88-6)

Conditions	Yield
With caesium carbonate In acetonitrile for 0.5h; Heating;	98%
With potassium fluoride; tetra(n-butyl)ammonium hydrogensulfate In tetrahydrofuran at 20℃; for 72h; Inert atmosphere;	98%

mesitylenecarboxylic acid (480-63-7) + Triethyl orthoacetate (78-39-7) → ethyl 2,4,6-trimethylbenzoate (1754-55-8)

Conditions	Yield
microwave irradiation;	98%
In various solvent(s) at 80℃; for 1.5h;	96%

mesitylenecarboxylic acid (480-63-7) + cyclohexanylcarbonyl chloride (2719-27-9) → C17H22O3

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 6h;	98%

bis(trimethylsilyl)amide yttrium(III) + mesitylenecarboxylic acid (480-63-7) → yttrium tris(2,4,6-trimethylbenzoate) (197774-00-8)

Conditions	Yield
In tetrahydrofuran byproducts: HN(SiMe3)2; under vac.; to a soln. of Y-contg. compd. (1.50 mmol) in THF was slowly added a soln. of carboxylic acid (4.50 mmol) in THF at -45°C; stirring at ambient temp. overnight (16 h); the solvent and volatiles were removed in vac.; solid was washed severaltimes with hexane; drying for several hours; elem. anal.;	98%
In tetrahydrofuran Ar-atmosphere; stirring for 20 min; evapn. (reduced pressure), washing (PhMe, hexanes);	54%

mesitylenecarboxylic acid (480-63-7) + 4-Methoxybenzyl alcohol (105-13-5) → 4-methoxybenzyl 2,4,6-trimethylbenzoate

Conditions	Yield
With potassium carbonate In acetonitrile at 80℃; for 3h; Inert atmosphere;	98%

Upstream product

• 67-56-1 methanol 
• 1795-80-8 tert-butyl 2,4,6-trimethylbenzoate 
• 693-03-8 n-butyl magnesium bromide 
• 142-96-1 dibutyl ether 
• 2282-84-0 methyl 2,4,6-trimethylbenzoate 
• 4909-77-7 benzyl 2,4,6-trimethylbenzoate 
• 917-64-6 methyl magnesium iodide 
• 709028-15-9 2,4,6-trimethyl-benzoic acid bibenzyl-α-yl ester 
• 60-29-7 diethyl ether 
• 2000-88-6 allyl 2,4,6-trimethylbenzoate 
• 64-17-5 ethanol 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 67-66-3 chloroform 
• 17024-58-7 (E)-2,4,6-trimethylstilbene 

Downstream Products

• 2282-84-0 methyl 2,4,6-trimethylbenzoate 
• 4170-90-5 2,4,6-trimethylbenzyl alcohol 
• 479-47-0 benzene-1,2,3,5-tetracarboxylic acid 
• 5333-13-1 3-bromo-2,4,6-trimethylbenzoic acid 
• 108983-07-9 2,4,6-Trimethyl-benzoesaeure-(2-diethylamino-ethylester) 
• 55610-37-2 2,4,6-trimethyl-3,5-dinitro-benzoic acid 
• 89441-75-8 2c.4c.6c-trimethyl-cyclohexane-carboxylic acid-(1r) 
• 106567-41-3 2,4,6-trimethyl-3-nitrobenzoic acid 
• 80238-12-6 2,6-dimethyl-terephthalic acid 
• 938-18-1 mesitylene-2-carboxylic acid chloride 
• 108881-54-5 (carbonic acid ethyl ester)-(2,4,6-trimethyl-benzoic acid )-anhydride 
• 41589-61-1 isopropyl 2,4,6-trimethylbenzoate 
• 79444-24-9 2,3,4,6-tetra-O-acetyl-1-O-(2,4,6-trimethylbenzoyl)-α-D-glucopyranose 
• 14036-52-3 Mesitylcarbonsaeure-(diethoxymethylester) 

Relevant academic research and scientific papers

Electrophilic aromatic substitution of arenes with CO2 mediated by R3SiB(C6F5)4

The FriedelCrafts- type carboxylation of arenes has been achieved by activating CO2 with silylium borates. The reaction exhibits broader substrate applicability than does our previously reported AlX3/R 3SiX-mediated carboxylation.

Method for preparing 2, 4, 6-trimethylbenzoic acid from mesitylene and carbon dioxide

The invention discloses a method for preparing 2, 4, 6-trimethylbenzoic acid from mesitylene and carbon dioxide. The method comprises the step of synthesizing 2, 4, 6-trimethylbenzoic acid by taking mesitylene as a raw material, lewis acid as a catalyst and carbon dioxide as a carbon source under certain pressure and temperature. Oxidants such as potassium permanganate are not used. The method has the highest atom utilization rate of the synthesis reaction, and has atom economy and good industrial application prospect.

An efficient chromium(iii)-catalyzed aerobic oxidation of methylarenes in water for the green preparation of corresponding acids

A highly efficient method to oxidize methylarenes to their corresponding acids with a reusable Cr catalyst was developed. The reaction can be carried out in water with 1 atm oxygen and K2S2O8as cooxidants, proceeds under green and mild conditions, and is suitable for the oxidation of both electron-deficient and electron-rich methylarenes, including heteroaryl methylarenes, even at the gram level. The excellent result, together with its simplicity of operation and the ability to continuously reuse the catalyst, makes this new methodology environmentally benign and cost-effective. The generality of this methodology gives it the potential for use on an industrial scale. Differing from the accepted oxidation mechanism of toluene, GC-MS studies and DFT calculations have revealed that the key benzyl alcohol intermediate is formed under the synergetic effect of the chromium and molybdenum in the Cr catalyst, which can be further oxidized to afford benzaldehyde and finally benzoic acid.

Pd(II) porphyrins: Synthesis, singlet oxygen generation and photoassisted oxidation of aldehydes to carboxilic acids

The synthesis and spectral studies of A3B and A2B2 type porphyrins and their Pd(II) complexes are reported. The meso-positions on porphyrin macrocycle are substituted with pentafluorophenyl and N-butylcarbazole or triphenylamine groups. Pd(II) porphyrins displayed decent phosphorescence ～670 nm and are able to produce singlet oxygen by type II pathway, after photoirradiation. The calculated singlet oxygen quantum yields for Pd(II) porphyrins are (ΦΔ = 30%–63%). The catalytic application of Pd(II) porphyrins towards photoassisted aerobic oxidation of aromatic aldehydes to carboxylic acids is demonstrated.

Highly efficient oxidation of alcohols to carboxylic acids using a polyoxometalate-supported chromium(iii) catalyst and CO2

Direct catalytic oxidation of alcohols to carboxylic acids is very attractive, but economical catalysis systems have not yet been well established. Here, we show that a pure inorganic ligand-supported chromium compound, (NH4)3[CrMo6O18(OH)6] (simplified as CrMo6), could be used to effectively promote this type of reaction in the presence of CO2. In almost all cases, oxidation of various alcohols (aromatic and aliphatic) could be achieved under mild conditions, and the corresponding carboxylic acids can be achieved in high yield. The chromium catalyst 1 can be reused several times with little loss of activity. Mechanism study and control reactions demonstrate that the acidification proceeds via the key oxidative immediate of aldehydes.

Two-Phase Reactions in Microdroplets

Improved two phase chemical reactions (liquid-liquid or liquid-gas) are provided by forming microdroplets of either or both liquid reagents and configuring the reaction as a collision between the microdroplet reagent and the other reagent. We have found that this approach can provide high reaction yields in short times (1 s) without the use of a phase transfer catalyst.

Carboxylation of Aryl Triflates with CO2 Merging Palladium and Visible-Light-Photoredox Catalysts

We report herein a visible-light-promoted, highly practical carboxylation of readily accessible aryl triflates at ambient temperature and a balloon pressure of CO2 by the combined use of palladium and photoredox Ir(III) catalysts. Strikingly, the stoichiometric metallic reductant is replaced by a nonmetallic amine reductant providing an environmentally benign carboxylation process. In addition, one-pot synthesis of a carboxylic acid directly from phenol and modification of estrone and concise synthesis of pharmaceutical drugs adapalene and bexarotene have been accomplished via late-stage carboxylation reaction. Furthermore, a parallel decarboxylation-carboxylation reaction has been demonstrated in an H-type closed vessel that is an interesting concept for the strategic sector. Spectroscopic and spectroelectrochemical studies indicated electron transfer from the Ir(III)/DIPEA combination to generate aryl carboxylate and Pd(0) for catalytic turnover.

Palladium-Catalyzed Visible-Light-Driven Carboxylation of Aryl and Alkenyl Triflates by Using Photoredox Catalysts

A visible-light-driven carboxylation of aryl and alkenyl triflates with CO2 is developed by using a combination of Pd and photoredox catalysts. This reaction proceeds under mild conditions and can be applied to a wide range of substrates including acyclic alkenyl triflates.

Palladium complex containing diphosphine m-carborane ligand as well as preparation and application of palladium complex

The invention relates to a palladium complex containing a diphosphine m-carborane ligand as well as a preparation and an application of the palladium complex. The preparation method of the palladium complex comprises the following steps of 1) adding an n-BuLi solution into a m-carborane solution, and then reacting for 30-60 minutes at a room temperature; 2) adding diphenyl phosphorus chloride, andreacting for 3-6 h at the room temperature; and 3) adding PdCl2, reacting at the room temperature for 3-5 hours, and carrying out post-treatment to obtain the palladium complex. The palladium complexis used for catalyzing the reaction of halohydrocarbon with carbon dioxide to synthesize carboxylic acid. Compared with the prior art, the synthesis process is simple and green, and has the excellentselectivity and high yield; the palladium complex has the stable physicochemical properties and is used as the catalyst, the halogenated hydrocarbon is used as a substrate, the palladium complex andthe halogenated hydrocarbon are jointly dissolved in toluene, and the carbon dioxide is introduced at the normal pressure for reaction, so that the corresponding carboxylic acid can be synthesized athigh yield.

Substituted arene formyl chloride synthesis method

The invention relates to the technical field of synthesis of fine chemical intermediates, particularly to a substituted arene formyl chloride synthesis method, which comprises: carrying out a reactionon substituted arene formic acid and substituted trichloromethyl arene under the action of a catalyst 3 to obtain the substituted arene formyl chloride. According to the present invention, the synthesis method has characteristics of inexpensive and easily-available raw materials, short process route, good production safety, easy separation of catalyst, high atomic utilization rate, less waste acid discharge, simple post-treatment, high yield and good quality, and is suitable for industrial continuous production.