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    Cas No: 480-63-7

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480-63-7 Usage

Chemical Properties

white to almost white crystalline powder

Uses

Mesitoic acid can be used for its antioxidant.

Definition

ChEBI: A trimethylbenzoic acid in which the three methyl substituents are located at positions 2, 4 and 6.

Synthesis Reference(s)

Journal of the American Chemical Society, 96, p. 590, 1974 DOI: 10.1021/ja00809a049Organic Syntheses, Coll. Vol. 3, p. 553, 1955Tetrahedron Letters, 11, p. 4459, 1970

Purification Methods

Crystallise mesitoic acid from water, ligroin or carbon tetrachloride [Ohwada et al. J Am Chem Soc 108 3029 1986]. [Beilstein 9 H 553, 9 I 214, 9 II 360, 9 III 2489, 9 IV 1854.]

Check Digit Verification of cas no

The CAS Registry Mumber 480-63-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 0 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 480-63:
(5*4)+(4*8)+(3*0)+(2*6)+(1*3)=67
67 % 10 = 7
So 480-63-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H12O2/c1-6-4-7(2)9(10(11)12)8(3)5-6/h4-5H,1-3H3,(H,11,12)/p-1

480-63-7 Well-known Company Product Price

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  • Alfa Aesar

  • (A11831)  2,4,6-Trimethylbenzoic acid, 99%   

  • 480-63-7

  • 10g

  • 528.0CNY

  • Detail
  • Alfa Aesar

  • (A11831)  2,4,6-Trimethylbenzoic acid, 99%   

  • 480-63-7

  • 50g

  • 2003.0CNY

  • Detail
  • Alfa Aesar

  • (A11831)  2,4,6-Trimethylbenzoic acid, 99%   

  • 480-63-7

  • 250g

  • 8455.0CNY

  • Detail

480-63-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,4,6-trimethylbenzoic acid

1.2 Other means of identification

Product number -
Other names Mesitylenecarboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:480-63-7 SDS

480-63-7Synthetic route

carbon dioxide
124-38-9

carbon dioxide

1,3,5-trimethyl-benzene
108-67-8

1,3,5-trimethyl-benzene

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

Conditions
ConditionsYield
With Et3SiB(C6F5)4 at 20℃; under 22502.3 Torr; for 18h; Reagent/catalyst;100%
With aluminum tri-bromide; Triphenylsilyl chloride at 20℃; under 22502.3 Torr; for 3h; Autoclave;97%
With aluminum (III) chloride at 30℃; under 15001.5 Torr; for 5h; Pressure; Temperature;95.2%
carbon dioxide
124-38-9

carbon dioxide

2-mesitylmagnesium bromide
2633-66-1

2-mesitylmagnesium bromide

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

Conditions
ConditionsYield
Stage #1: carbon dioxide; 2-mesitylmagnesium bromide In tetrahydrofuran at 20℃; under 3000.3 Torr; gas-liquid flow reactor assembly;
Stage #2: With polymer-supported sulfonic acid In tetrahydrofuran
100%
In tetrahydrofuran at 1℃; for 0.0833333h;74%
2,4,6-trimethyl-benzoic acid-anhydride
5745-51-7

2,4,6-trimethyl-benzoic acid-anhydride

A

2,4,6-trimethylbenzyl alcohol
4170-90-5

2,4,6-trimethylbenzyl alcohol

B

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

Conditions
ConditionsYield
With Li(1+)*C12H28AlO3(1-) In tetrahydrofuran; hexane at -78℃; for 1h;A 99%
B 98%
mesytaldehyde
487-68-3

mesytaldehyde

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

Conditions
ConditionsYield
With C4H11FeMo6NO24(3-)*3C16H36N(1+); water; oxygen; sodium carbonate at 50℃; under 760.051 Torr; for 8h; Green chemistry;99%
With 4H3N*4H(1+)*CuMo6O18(OH)6(4-); water; oxygen; sodium carbonate at 50℃; under 760.051 Torr; for 12h;99%
With tris[2-(4,6-difluorophenyl)pyridinato-C2,N]-iridium(III); oxygen In acetonitrile at 20℃; Irradiation; Sealed tube; Green chemistry; chemoselective reaction;90%
2,4,6-trimethylbenzyl alcohol
4170-90-5

2,4,6-trimethylbenzyl alcohol

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

Conditions
ConditionsYield
With dihydrogen peroxide In water; toluene at 20 - 85℃; for 4h;98%
With diethylene glycol dimethyl ether at 70℃; for 0.5h; Sonication;93%
With potassium phosphate; carbon dioxide; CrH6Mo6O24(3-)*3H3N*3H(1+) In dimethyl sulfoxide at 80℃; under 750.075 Torr; for 24h; Green chemistry;84%
carbon dioxide
124-38-9

carbon dioxide

2,4,6-trimethylbenzeneboronic acid neopentyl glycol cyclic ester
214360-78-8

2,4,6-trimethylbenzeneboronic acid neopentyl glycol cyclic ester

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

Conditions
ConditionsYield
With potassium tert-butylate; copper(l) chloride; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride In tetrahydrofuran at 70℃; under 760.051 Torr; for 24h;98%
methyl 2,4,6-trimethylbenzoate
2282-84-0

methyl 2,4,6-trimethylbenzoate

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

Conditions
ConditionsYield
With tetra(n-butyl)ammonium hydroxide In tetrahydrofuran; water at 70℃; for 1h;97%
With potassium hydroxide; Aliquat 336 at 200℃; for 0.0833333h; microwave irradiation;95%
With Me2AlTeMe In toluene at 23℃; for 6h;91%
n-octyl mesitoate
99921-94-5

n-octyl mesitoate

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

Conditions
ConditionsYield
With sodium hydroxide; Aliquat 336 at 200℃; for 0.0833333h; microwave irradiation;97%
Trichloroacetyl chloride
76-02-8

Trichloroacetyl chloride

1,3,5-trimethyl-benzene
108-67-8

1,3,5-trimethyl-benzene

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

Conditions
ConditionsYield
Stage #1: trifluoroacetyl chloride; 1,3,5-trimethyl-benzene With aluminum (III) chloride at 0 - 10℃; for 2h; Inert atmosphere;
Stage #2: With hydrogenchloride In water Temperature;
95%
C26H30O2Si

C26H30O2Si

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

Conditions
ConditionsYield
With water; N,N-dimethyl-formamide at 70℃; for 3h; Green chemistry; chemoselective reaction;94%
With N,N,N',N'-tetramethylguanidine In acetonitrile at 50℃; for 1h;92%
formic acid
64-18-6

formic acid

1,3,5-trimethyl-benzene
108-67-8

1,3,5-trimethyl-benzene

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

Conditions
ConditionsYield
With dipotassium peroxodisulfate; (4-CH3O-C6H4-N-CH2)2PO3SCF3; palladium(II) trifluoroacetate In trifluoroacetic acid at 30℃; for 48h;93%
C19H32O2Si

C19H32O2Si

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

Conditions
ConditionsYield
With water; N,N-dimethyl-formamide at 70℃; for 3h; Green chemistry; chemoselective reaction;93%
2,4,6-trimethyl-benzoic acid 2-trimethylsilanyl-ethyl ester

2,4,6-trimethyl-benzoic acid 2-trimethylsilanyl-ethyl ester

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 20℃;92%
methyl 2,4,6-trimethylbenzoate
2282-84-0

methyl 2,4,6-trimethylbenzoate

diphenyl diselenide
1666-13-3

diphenyl diselenide

A

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

B

selenoanisole
4346-64-9

selenoanisole

Conditions
ConditionsYield
Stage #1: diphenyl diselenide With aluminum (III) chloride; zinc In acetonitrile at 70℃; under 760.051 Torr; for 1.25h; Neutral;
Stage #2: methyl 2,4,6-trimethylbenzoate In acetonitrile at 70℃; under 760.051 Torr; for 6h; Neutral;
A 92%
B n/a
allyl 2,4,6-trimethylbenzoate
2000-88-6

allyl 2,4,6-trimethylbenzoate

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

Conditions
ConditionsYield
With Me2AlTeMe In toluene at 23℃; for 12h;89%
With dichloro bis(acetonitrile) palladium(II); cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate; diethylene glycol dimethyl ether; 1,6-bis(diphenylphosphino)hexane; water In 1,2-dimethoxyethane; dichloromethane at 20 - 85℃; for 1.33333h; Inert atmosphere;26 %Chromat.
iodomesitylene
4028-63-1

iodomesitylene

carbon dioxide
124-38-9

carbon dioxide

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

Conditions
ConditionsYield
With C26H30B10Cl2P2Pd In toluene at 80℃; under 760.051 Torr; for 8h;89%
With copper(l) iodide; diethylzinc; N,N`-dimethylethylenediamine In dimethyl sulfoxide at 25℃; under 760.051 Torr;61%
carbon dioxide
124-38-9

carbon dioxide

1,3,5-trimethyl-benzene
108-67-8

1,3,5-trimethyl-benzene

A

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

B

dimesityl ketone
5623-45-0

dimesityl ketone

Conditions
ConditionsYield
With chloro-trimethyl-silane; aluminum tri-bromide at 20℃; under 22501.8 Torr; for 3h;A 87%
B 6%
With chloro-trimethyl-silane; aluminum tri-bromide at 20℃; under 22502.3 Torr; for 3h; Autoclave;A 87%
B 6%
With Et3SiB(C6F5)4 at 20℃; under 22502.3 Torr; for 18h; Reagent/catalyst; Friedel-Crafts Acylation;A 86%
B 14%
With aluminum tri-bromide under 44130.5 Torr;
benzyl 2,4,6-trimethylbenzoate
4909-77-7

benzyl 2,4,6-trimethylbenzoate

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

Conditions
ConditionsYield
With Me2AlTeMe In toluene at 23℃; for 14h;87%
With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate at 20℃; for 0.25h; chemoselective reaction;85%
sodium methyl carbonate
6482-39-9

sodium methyl carbonate

2-mesitylmagnesium bromide
2633-66-1

2-mesitylmagnesium bromide

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

Conditions
ConditionsYield
In diethyl ether at 20℃; for 24h; Inert atmosphere;85%
carbon dioxide
124-38-9

carbon dioxide

2,4,6-trimethylbenzenesulfonate sodium salt
6148-75-0

2,4,6-trimethylbenzenesulfonate sodium salt

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

Conditions
ConditionsYield
Stage #1: carbon dioxide; 2,4,6-trimethylbenzenesulfonate sodium salt With copper(l) iodide; potassium tert-butylate; o-phenanthroline In dimethyl sulfoxide at 140℃; under 760.051 Torr; for 12h; Schlenk technique;
Stage #2: With hydrogenchloride In water; dimethyl sulfoxide Schlenk technique;
82%
carbon dioxide
124-38-9

carbon dioxide

sodium 2,4,6-trimethylbenzenesulfinic acid
50827-54-8

sodium 2,4,6-trimethylbenzenesulfinic acid

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

Conditions
ConditionsYield
With copper(l) iodide; 1,10-Phenanthroline; potassium tert-butylate In dimethyl sulfoxide at 140℃; under 750.075 Torr; for 3h; Schlenk technique; Sealed tube;82%
1-mesityl-5-phenyl-6,7,8-trioxabicyclo<3.2.1>octane

1-mesityl-5-phenyl-6,7,8-trioxabicyclo<3.2.1>octane

A

4-hydroxy-1-phenyl-butan-1-one
39755-03-8

4-hydroxy-1-phenyl-butan-1-one

B

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

C

butyrophenone
495-40-9

butyrophenone

D

3,4-dihydronaphthalene-1(2H)-one
529-34-0

3,4-dihydronaphthalene-1(2H)-one

Conditions
ConditionsYield
With iron(II) sulfate In tetrahydrofuran; water at 20℃; for 16h;A 9%
B 81%
C 26%
D 13%
1,2,3,4-tetrahydro-1-naphthyl ester of 2,4,6-trimethylbenzoic acid

1,2,3,4-tetrahydro-1-naphthyl ester of 2,4,6-trimethylbenzoic acid

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

Conditions
ConditionsYield
With chloro-trimethyl-silane; sodium iodide In acetonitrile at 20℃; for 1h; Substitution;80%
2,4,6-Trimethylacetophenone
1667-01-2

2,4,6-Trimethylacetophenone

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

Conditions
ConditionsYield
With oxygen; manganese (II) acetate tetrahydrate; cobalt(II) diacetate tetrahydrate In acetic acid at 100℃; under 760.051 Torr; for 15h;78%
With permanganate(VII) ion anschl. Behandeln mit Schwefelsaeure;
Multi-step reaction with 2 steps
1: KMnO4; alkali
2: bei der Destillation
View Scheme
carbon dioxide
124-38-9

carbon dioxide

2,4,6-trimethylphenyl trifluoromethanesulfonate
125261-32-7

2,4,6-trimethylphenyl trifluoromethanesulfonate

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

Conditions
ConditionsYield
Stage #1: carbon dioxide; 2,4,6-trimethylphenyl trifluoromethanesulfonate With manganese; [Co(2,9-dimethyl-1,10-phenanthroline)I2] In N,N-dimethyl acetamide at 40℃; under 760.051 Torr; for 20h; Schlenk technique;
Stage #2: With hydrogenchloride In diethyl ether; water at 20℃; for 0.166667h; Temperature; Reagent/catalyst; Schlenk technique;
77%
With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; DavePhos In N,N-dimethyl acetamide at 20℃; for 36h; Irradiation; Green chemistry; chemoselective reaction;75%
With (2’,4’,6’-triisopropyl-[1,1’-biphenyl]-2-yl)-diphenylphosphine; bis(2-phenylpyridinato)(2,2'-bipyridine)iridium(III) hexafluorophosphate; tetrabutylammomium bromide; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide at 20℃; under 760.051 Torr; for 4h; Irradiation;
[(3R,4S)-2-(4-Nitro-phenyl)-5-phenyl-4-(2,4,6-trimethyl-benzoyl)-3,4-dihydro-2H-pyrazol-3-yl]-(2,4,6-trimethyl-phenyl)-methanone
78830-35-0

[(3R,4S)-2-(4-Nitro-phenyl)-5-phenyl-4-(2,4,6-trimethyl-benzoyl)-3,4-dihydro-2H-pyrazol-3-yl]-(2,4,6-trimethyl-phenyl)-methanone

A

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

B

[1-(4-Nitro-phenyl)-3-phenyl-1H-pyrazol-4-yl]-(2,4,6-trimethyl-phenyl)-methanone
78830-48-5

[1-(4-Nitro-phenyl)-3-phenyl-1H-pyrazol-4-yl]-(2,4,6-trimethyl-phenyl)-methanone

Conditions
ConditionsYield
at 200℃; for 0.166667h;A 65%
B 75%
C18H20O2

C18H20O2

A

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

B

4-methoxybenzoic acid
100-09-4

4-methoxybenzoic acid

Conditions
ConditionsYield
With oxygen; potassium hydroxide at 20℃; Schlenk technique; chemoselective reaction;A 62%
B 63%
[(3R,4S)-2,5-Di-p-tolyl-4-(2,4,6-trimethyl-benzoyl)-3,4-dihydro-2H-pyrazol-3-yl]-(2,4,6-trimethyl-phenyl)-methanone
78830-39-4

[(3R,4S)-2,5-Di-p-tolyl-4-(2,4,6-trimethyl-benzoyl)-3,4-dihydro-2H-pyrazol-3-yl]-(2,4,6-trimethyl-phenyl)-methanone

A

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

B

(1,3-Di-p-tolyl-1H-pyrazol-4-yl)-(2,4,6-trimethyl-phenyl)-methanone
78830-51-0

(1,3-Di-p-tolyl-1H-pyrazol-4-yl)-(2,4,6-trimethyl-phenyl)-methanone

Conditions
ConditionsYield
at 200℃; for 0.166667h;A 30%
B 55%
2-(2,4,6-trimethylphenyl)-2-hydroxyacetonitrile
49685-65-6

2-(2,4,6-trimethylphenyl)-2-hydroxyacetonitrile

A

mesytaldehyde
487-68-3

mesytaldehyde

B

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

Conditions
ConditionsYield
Stage #1: 2-hydroxy-2-(2,4,6-trimethylphenyl)acetonitrile With (η(6)-benzene)chloro[1,2-bis(diphenylphosphino)ethane]ruthenium(II) chloride In benzene at 120℃; for 24h; Inert atmosphere; Schlenk technique;
Stage #2: With water In dichloromethane; ethyl acetate; benzene for 24h;
A 40%
B 55%
mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

methyl 2,4,6-trimethylbenzoate
2282-84-0

methyl 2,4,6-trimethylbenzoate

Conditions
ConditionsYield
In diethyl ether100%
With diethyl ether
methanol
67-56-1

methanol

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

methyl 2,4,6-trimethylbenzoate
2282-84-0

methyl 2,4,6-trimethylbenzoate

Conditions
ConditionsYield
With sulfuric acid at 148 - 159℃; under 9375.7 Torr; for 0.0866667h; Irradiation;100%
With dmap; dicyclohexyl-carbodiimide
With fluorosulphonic acid at -70℃; Yield given;
With sulfuric acid at 20℃; for 48h;
With sulfuric acid at 100℃; for 24h;
mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

ethyl iodide
75-03-6

ethyl iodide

ethyl 2,4,6-trimethylbenzoate
1754-55-8

ethyl 2,4,6-trimethylbenzoate

Conditions
ConditionsYield
With caesium carbonate In acetonitrile for 2h; Heating;100%
With cesium fluoride In acetonitrile for 1h; Heating;99%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In benzene
With potassium carbonate In acetone for 16h; Heating;
With cesium fluoride In N,N-dimethyl-formamide at 10 - 15℃; for 24h;88 % Chromat.
mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

methyl 6'-O-butyryl-β-lactoside
141484-96-0

methyl 6'-O-butyryl-β-lactoside

methyl 6'-O-butyryl-2,2',3,3',4',6-hexa-O-mesitoyl-β-lactoside
141485-04-3

methyl 6'-O-butyryl-2,2',3,3',4',6-hexa-O-mesitoyl-β-lactoside

Conditions
ConditionsYield
With trifluoroacetic anhydride In benzene for 2h; Ambient temperature;100%
mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

aniline
62-53-3

aniline

2,4,6-trimethyl-N-phenylbenzamide
5215-40-7

2,4,6-trimethyl-N-phenylbenzamide

Conditions
ConditionsYield
With diphosphorus tetraiodide In tetrachloromethane; dichloromethane Heating;100%
With ethylene dichloride hydrochloride; triethylamine In dichloromethane at 0 - 20℃; for 6h;
mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

potassium 2,4,6-trimethylbenzoate

potassium 2,4,6-trimethylbenzoate

Conditions
ConditionsYield
With potassium tert-butylate In methanol at 20℃; for 4h;100%
With potassium tert-butylate In methanol for 4h;82%
2-iodo-propane
75-30-9

2-iodo-propane

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

isopropyl 2,4,6-trimethylbenzoate
41589-61-1

isopropyl 2,4,6-trimethylbenzoate

Conditions
ConditionsYield
With N(Et)4(1+)*(2-pyrrolidone-anion) In N,N-dimethyl-formamide for 1h; Ambient temperature;99%
With caesium carbonate In acetonitrile for 2h; Heating;96%
With potassium carbonate In acetone for 16h; Heating;
dichloromethane
75-09-2

dichloromethane

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

Methylendi-<2,4,6-trimethylbenzoesaeure>-ester
56741-13-0

Methylendi-<2,4,6-trimethylbenzoesaeure>-ester

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 130℃; for 5h;99%
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate
styrene
292638-84-7

styrene

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

(E)-2,4,6-trimethylstilbene
17024-58-7

(E)-2,4,6-trimethylstilbene

Conditions
ConditionsYield
With silver carbonate; palladium(II) trifluoroacetate In dimethyl sulfoxide; N,N-dimethyl-formamide at 120℃; for 1.5h; Heck olefination;99%
mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

poly(styrene-co-divinylbenzene)-supported methyl sulfonate, loading rate of SO3Me: ca. 4.0 mmol/g

poly(styrene-co-divinylbenzene)-supported methyl sulfonate, loading rate of SO3Me: ca. 4.0 mmol/g

methyl 2,4,6-trimethylbenzoate
2282-84-0

methyl 2,4,6-trimethylbenzoate

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 4h; Heating;99%
mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

trimethylaluminum
75-24-1

trimethylaluminum

[Me2Al(μ-2,4,6-trimethylbenzoate)]2
884337-83-1

[Me2Al(μ-2,4,6-trimethylbenzoate)]2

Conditions
ConditionsYield
In hexane byproducts: CH4; in a glovebox, Al-contg. compd. (2.00 mmol) was slowly added to a cooledhexane suspn. (-35.degree C) of carboxylic acid (2.00 mmol); stirring a t ambient temp. for 3 h; the solvent was removed in vac.; elem. anal.;99%
[RhCl2(p-cymene)]2

[RhCl2(p-cymene)]2

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

Ru(mesitylCO2)2(p-cymene)

Ru(mesitylCO2)2(p-cymene)

Conditions
ConditionsYield
With potassium carbonate In toluene at 20℃; for 2h; Inert atmosphere;99%
mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

N-(2-methylbenzoyl)-8-aminoquinoline
1182669-71-1

N-(2-methylbenzoyl)-8-aminoquinoline

3-methyl-2-(quinolin-8-ylcarbamoyl)phenyl 2,4,6-trimethylbenzoate

3-methyl-2-(quinolin-8-ylcarbamoyl)phenyl 2,4,6-trimethylbenzoate

Conditions
ConditionsYield
With cobalt(II) acetate; sodium carbonate; silver sulfate In 1,2-dichloro-ethane at 80℃; for 24h; Inert atmosphere; Sealed tube; regioselective reaction;99%
mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

aniline
62-53-3

aniline

N-(2,4,6-trimethylphenyl)-N'-phenylurea
2904-67-8

N-(2,4,6-trimethylphenyl)-N'-phenylurea

Conditions
ConditionsYield
With diphenyl phosphoryl azide; triethylamine In toluene at 100℃; for 0.0166667h; Curtius Rearrangement; Microwave irradiation;99%
mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

2-(2,4,6-trimethylphenyl)-1H-benzoimidazole
36677-31-3

2-(2,4,6-trimethylphenyl)-1H-benzoimidazole

Conditions
ConditionsYield
With Eaton’s reagent at 140℃; for 0.5h; Inert atmosphere;98.6%
With Eaton′s Reagent at 120 - 140℃; for 0.5h; Inert atmosphere;98.6%
With polyphosphoric acid at 200℃; for 2h;80%
With polyphosphoric acid at 120 - 150℃; for 16h;62%
ethyl bromide
74-96-4

ethyl bromide

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

ethyl 2,4,6-trimethylbenzoate
1754-55-8

ethyl 2,4,6-trimethylbenzoate

Conditions
ConditionsYield
With potassium hydroxide; Aliquat 336 at 60℃; for 1h;98%
With potassium carbonate In acetone at 100℃; for 0.166667h; microwave irradiation;94%
With tetradecyl(trihexyl)phosphonium bistriflamide; N-ethyl-N,N-diisopropylamine at 30℃;86%
mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

benzylamine
100-46-9

benzylamine

N-benzyl-2,4,6-trimethylbenzamide
104385-10-6

N-benzyl-2,4,6-trimethylbenzamide

Conditions
ConditionsYield
With TEA; diphenyl (2,3-dihydro-2-thioxo-3-benzoxazolyl)phosphonate In various solvent(s) for 2h; Ambient temperature;98%
With 1-methyl-pyrrolidin-2-one; 3,3'-(phenylphosphinylidene)bis<2(3H)-benzothiazolone; triethylamine Ambient temperature;91%
mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

benzyl alcohol
100-51-6

benzyl alcohol

benzyl 2,4,6-trimethylbenzoate
4909-77-7

benzyl 2,4,6-trimethylbenzoate

Conditions
ConditionsYield
With pyridine at 115℃; for 0.5h;98%
mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

methyl iodide
74-88-4

methyl iodide

methyl 2,4,6-trimethylbenzoate
2282-84-0

methyl 2,4,6-trimethylbenzoate

Conditions
ConditionsYield
With potassium hydroxide; Aliquat 336 at 20℃; for 1h;98%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere;88%
mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

allyl bromide
106-95-6

allyl bromide

allyl 2,4,6-trimethylbenzoate
2000-88-6

allyl 2,4,6-trimethylbenzoate

Conditions
ConditionsYield
With caesium carbonate In acetonitrile for 0.5h; Heating;98%
With potassium fluoride; tetra(n-butyl)ammonium hydrogensulfate In tetrahydrofuran at 20℃; for 72h; Inert atmosphere;98%
mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

ethyl 2,4,6-trimethylbenzoate
1754-55-8

ethyl 2,4,6-trimethylbenzoate

Conditions
ConditionsYield
microwave irradiation;98%
In various solvent(s) at 80℃; for 1.5h;96%
mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

cyclohexanylcarbonyl chloride
2719-27-9

cyclohexanylcarbonyl chloride

C17H22O3

C17H22O3

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 6h;98%
bis(trimethylsilyl)amide yttrium(III)

bis(trimethylsilyl)amide yttrium(III)

mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

yttrium tris(2,4,6-trimethylbenzoate)
197774-00-8

yttrium tris(2,4,6-trimethylbenzoate)

Conditions
ConditionsYield
In tetrahydrofuran byproducts: HN(SiMe3)2; under vac.; to a soln. of Y-contg. compd. (1.50 mmol) in THF was slowly added a soln. of carboxylic acid (4.50 mmol) in THF at -45°C; stirring at ambient temp. overnight (16 h); the solvent and volatiles were removed in vac.; solid was washed severaltimes with hexane; drying for several hours; elem. anal.;98%
In tetrahydrofuran Ar-atmosphere; stirring for 20 min; evapn. (reduced pressure), washing (PhMe, hexanes);54%
mesitylenecarboxylic acid
480-63-7

mesitylenecarboxylic acid

4-Methoxybenzyl alcohol
105-13-5

4-Methoxybenzyl alcohol

4-methoxybenzyl 2,4,6-trimethylbenzoate

4-methoxybenzyl 2,4,6-trimethylbenzoate

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 80℃; for 3h; Inert atmosphere;98%

480-63-7Relevant articles and documents

Pinkus et al.

, p. 2649 (1967)

Electrophilic aromatic substitution of arenes with CO2 mediated by R3SiB(C6F5)4

Konno, Megumi,Chiba, Masafumi,Nemoto, Koji,Hattori, Tetsutaro

, p. 913 - 914,2 (2012)

The FriedelCrafts- type carboxylation of arenes has been achieved by activating CO2 with silylium borates. The reaction exhibits broader substrate applicability than does our previously reported AlX3/R 3SiX-mediated carboxylation.

Effect of cations, substrates and temperature on the microwave-assisted saponification of benzoic and mesitoic esters

Perreux, Laurence,Loupy, Andre

, p. 361 - 368 (2003)

-

Method for preparing 2, 4, 6-trimethylbenzoic acid from mesitylene and carbon dioxide

-

Paragraph 0019-0030, (2021/04/17)

The invention discloses a method for preparing 2, 4, 6-trimethylbenzoic acid from mesitylene and carbon dioxide. The method comprises the step of synthesizing 2, 4, 6-trimethylbenzoic acid by taking mesitylene as a raw material, lewis acid as a catalyst and carbon dioxide as a carbon source under certain pressure and temperature. Oxidants such as potassium permanganate are not used. The method has the highest atom utilization rate of the synthesis reaction, and has atom economy and good industrial application prospect.

Highly efficient oxidation of alcohols to carboxylic acids using a polyoxometalate-supported chromium(iii) catalyst and CO2

Han, Sheng,Wang, Ying,Wei, Yongge,Wu, Zhikang,Yu, Han

, p. 3150 - 3154 (2020/06/19)

Direct catalytic oxidation of alcohols to carboxylic acids is very attractive, but economical catalysis systems have not yet been well established. Here, we show that a pure inorganic ligand-supported chromium compound, (NH4)3[CrMo6O18(OH)6] (simplified as CrMo6), could be used to effectively promote this type of reaction in the presence of CO2. In almost all cases, oxidation of various alcohols (aromatic and aliphatic) could be achieved under mild conditions, and the corresponding carboxylic acids can be achieved in high yield. The chromium catalyst 1 can be reused several times with little loss of activity. Mechanism study and control reactions demonstrate that the acidification proceeds via the key oxidative immediate of aldehydes.

Substituted arene formyl chloride synthesis method

-

Paragraph 0089; 0090; 0093; 0094; 0097; 0098, (2019/04/18)

The invention relates to the technical field of synthesis of fine chemical intermediates, particularly to a substituted arene formyl chloride synthesis method, which comprises: carrying out a reactionon substituted arene formic acid and substituted trichloromethyl arene under the action of a catalyst 3 to obtain the substituted arene formyl chloride. According to the present invention, the synthesis method has characteristics of inexpensive and easily-available raw materials, short process route, good production safety, easy separation of catalyst, high atomic utilization rate, less waste acid discharge, simple post-treatment, high yield and good quality, and is suitable for industrial continuous production.

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