4-((3-(1,3-dioxoisoindolin-2-yl)propyl)(methyl)amino)benzaldehyde

Base Information

• Chemical Name: 4-((3-(1,3-dioxoisoindolin-2-yl)propyl)(methyl)amino)benzaldehyde
• CAS No.: 1426399-74-7
• Molecular Formula: C₁₉H₁₈N₂O₃
• Molecular Weight: 322.364
• Mol file: 1426399-74-7.mol

Synonyms:4-((3-(1,3-dioxoisoindolin-2-yl)propyl)(methyl)amino)benzaldehyde

Chemical Property of 4-((3-(1,3-dioxoisoindolin-2-yl)propyl)(methyl)amino)benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((3-(1,3-dioxoisoindolin-2-yl)propyl)(methyl)amino)benzaldehyde

There total 3 articles about 4-((3-(1,3-dioxoisoindolin-2-yl)propyl)(methyl)amino)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-(3-(methyl(phenyl)amino)propyl)isoindoline-1,3-dione (53100-74-6) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-((3-(1,3-dioxoisoindolin-2-yl)propyl)(methyl)amino)benzaldehyde (1426399-74-7)

Guidance literature:

N,N-dimethyl-formamide; With trichlorophosphate; at 0 - 20 ℃; for 2.5h; Inert atmosphere;

2-(3-(methyl(phenyl)amino)propyl)isoindoline-1,3-dione; In N,N-dimethyl-formamide; at 95 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.tet.2013.01.075

Reference yield:

2-(3-bromopropyl)isoindole-1,3-dione (5460-29-7) → 4-((3-(1,3-dioxoisoindolin-2-yl)propyl)(methyl)amino)benzaldehyde (1426399-74-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / acetonitrile / 18 h / Reflux

2.1: trichlorophosphate / 2.5 h / 0 - 20 °C / Inert atmosphere

2.2: 4 h / 95 °C / Inert atmosphere

With potassium carbonate; trichlorophosphate; In acetonitrile;

DOI:10.1016/j.tet.2013.01.075

Reference yield:

N-methylaniline (100-61-8) → 4-((3-(1,3-dioxoisoindolin-2-yl)propyl)(methyl)amino)benzaldehyde (1426399-74-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / acetonitrile / 18 h / Reflux

2.1: trichlorophosphate / 2.5 h / 0 - 20 °C / Inert atmosphere

2.2: 4 h / 95 °C / Inert atmosphere

With potassium carbonate; trichlorophosphate; In acetonitrile;

DOI:10.1016/j.tet.2013.01.075

upstream raw materials:

N-methylaniline

2-(3-bromopropyl)isoindole-1,3-dione

2-(3-(methyl(phenyl)amino)propyl)isoindoline-1,3-dione

N,N-dimethyl-formamide

Downstream raw materials:

(E,E)-1-(4(dibutylamino)styryl)-4-(((3-(1,3-dioxoisoindolin-2-yl)propyl)(methyl)amino)styryl)-2,3,5,6-tetrafluorobenzene

N¹-(4-(4-(4-(dibutylamino)styryl)-2,3,5,6-tetrafluorostyryl)phenyl)-N¹-methylpropane-1,3-diamine

N-(3-((4-(4-(4-(dibutylamino)styryl)-2,3,5,6-tetrafluorostyryl)phenyl)(methyl)amino)propyl)acetamide

N¹-(3-((4-(4-(4-(dibutylamino)styryl)-2,3,5,6-tetrafluorostyryl)phenyl)(methyl)amino)propyl)-N³,N⁵-bis(3-(4-methyl-2-oxo-2H-chromen-7-yloxy)propyl)benzene-1,3,5-tricarboxamide

Refernces