ethyl 3-[N-(t-butoxycarbonyl)-N-methylamino]-3-[(3-dimethylcarbamoyloxy)phenyl]propionate

Base Information

Chemical Name:ethyl 3-[N-(t-butoxycarbonyl)-N-methylamino]-3-[(3-dimethylcarbamoyloxy)phenyl]propionate
CAS No.:444646-08-6
Molecular Formula:C₂₀H₃₀N₂O₆
Molecular Weight:394.468
Hs Code.:

Synonyms:ethyl 3-[N-(t-butoxycarbonyl)-N-methylamino]-3-[(3-dimethylcarbamoyloxy)phenyl]propionate

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Chemical Property of ethyl 3-[N-(t-butoxycarbonyl)-N-methylamino]-3-[(3-dimethylcarbamoyloxy)phenyl]propionate

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Technology Process of ethyl 3-[N-(t-butoxycarbonyl)-N-methylamino]-3-[(3-dimethylcarbamoyloxy)phenyl]propionate

There total 5 articles about ethyl 3-[N-(t-butoxycarbonyl)-N-methylamino]-3-[(3-dimethylcarbamoyloxy)phenyl]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 79-44-7
N,N-Dimethylcarbamoyl chloride

: 444646-07-5
3-(tert-butoxycarbonyl(methyl)amino)-3-(3-hydroxyphenyl)propionic acid ethyl ester

: 444646-08-6
ethyl 3-[N-(t-butoxycarbonyl)-N-methylamino]-3-[(3-dimethylcarbamoyloxy)phenyl]propionate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 79-44-7
N,N-Dimethylcarbamoyl chloride

: 444646-08-6
ethyl 3-[N-(t-butoxycarbonyl)-N-methylamino]-3-[(3-dimethylcarbamoyloxy)phenyl]propionate

Guidance literature:: 3-(tert-butoxycarbonyl(methyl)amino)-3-(3-hydroxyphenyl)propionic acid ethyl ester; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.333333h;

N,N-Dimethylcarbamoyl chloride; at 20 ℃; for 1h;

Reference yield:

: 100-83-4
meta-hydroxybenzaldehyde

: 444646-08-6
ethyl 3-[N-(t-butoxycarbonyl)-N-methylamino]-3-[(3-dimethylcarbamoyloxy)phenyl]propionate

Guidance literature:: Multi-step reaction with 4 steps

1: 58 percent / ethanol / 2 h / 90 °C

2: 6.04 g / sulfuric acid / 6 h / 80 °C

3: 8.53 g / tetrahydrofuran / 12 h / 20 °C

4: 88 percent / K₂CO₃ / dimethylformamide / 3 h / 20 °C

With sulfuric acid; potassium carbonate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;