(S)-1-((S)-2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid 2-(4-bromo-3-fluoro-phenyl)-2-oxo-ethyl ester

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Chemical Name:(S)-1-((S)-2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid 2-(4-bromo-3-fluoro-phenyl)-2-oxo-ethyl ester
CAS No.:1399845-01-2
Molecular Formula:C₂₀H₂₄BrFN₂O₆
Molecular Weight:487.323
Hs Code.:

Synonyms:(S)-1-((S)-2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid 2-(4-bromo-3-fluoro-phenyl)-2-oxo-ethyl ester

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Chemical Property of (S)-1-((S)-2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid 2-(4-bromo-3-fluoro-phenyl)-2-oxo-ethyl ester

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Technology Process of (S)-1-((S)-2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid 2-(4-bromo-3-fluoro-phenyl)-2-oxo-ethyl ester

There total 1 articles about (S)-1-((S)-2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid 2-(4-bromo-3-fluoro-phenyl)-2-oxo-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 869569-77-7
1-(4-bromo-2-fluorophenyl)-2-bromo-1-ethanone

: 181827-47-4
(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidine-2-carboxylic acid

: 1399845-01-2
(S)-1-((S)-2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid 2-(4-bromo-3-fluoro-phenyl)-2-oxo-ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; potassium iodide; In acetonitrile; at 50 ℃; for 4h;

Reference yield: 49.0%

: 1399845-01-2
(S)-1-((S)-2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid 2-(4-bromo-3-fluoro-phenyl)-2-oxo-ethyl ester

: 1373165-26-4
((S)-1-{(S)-2-[5-(4-bromo-3-fluoro-phenyl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Guidance literature:: With ammonium acetate; In xylene; at 140 ℃; for 3h;

Reference yield:

: 1399845-01-2
(S)-1-((S)-2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid 2-(4-bromo-3-fluoro-phenyl)-2-oxo-ethyl ester

: 1399845-00-1
{(2S,5S)-2-[5-(2'-Fluoro-4'-{2-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-1H-imidazol-4-yl}-biphenyl-4-yl)-1H-imidazol-2-yl]-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-5-yl}-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium acetate / xylene / 3 h / 140 °C

2: potassium phosphate / palladium diacetate; ruphos / butan-1-ol; water / 3 h / 90 °C / Sealed tube; Inert atmosphere

With potassium phosphate; ammonium acetate; palladium diacetate; ruphos; In water; xylene; butan-1-ol;