181827-47-4Relevant articles and documents
5,5-FUSED ARYLENE OR HETEROARYLENE HEPATITIS C VIRUS INHIBITORS
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Paragraph 0234; 0235; 0236; 0237; 0238; 0239, (2018/08/20)
Provided herein are 5,5-fused heteroarylene hepatitis C virus inhibitor compounds, for example, of Formula I, IA, or IB, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.
Preparation method for daclatasvir
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, (2017/10/22)
The invention discloses a preparation method for daclatasvir. The preparation method comprises the following steps: in a solvent, performing a cyclization reaction on a compound shown as a formula D10 and ammonium acetate, so as to prepare the daclatasvir shown as a formula I, wherein the cyclization reaction is shown in the description. The preparation method for daclatasvir is low in cost, high in yield, friendly to environment, simple in steps, mild in reaction conditions and suitable for industrialized production.
Novel synthesis method of Daclatasvir
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Paragraph 0081; 0084, (2017/04/13)
The invention relates to a novel synthesis method of Daclatasvir, particularly discloses an intermediate for preparing Daclatasvir and a preparation method of the intermediate, and provides a preparation method of Daclatasvir. The method is more economical and more efficient.