(2R,3R)-3-ethyl-2-((R)-1-((1R,2R)-2-hydroxy-1,2-diphenylethoxy)heptyl)cyclohexanone

Base Information

• Chemical Name: (2R,3R)-3-ethyl-2-((R)-1-((1R,2R)-2-hydroxy-1,2-diphenylethoxy)heptyl)cyclohexanone
• CAS No.: 1262388-86-2
• Molecular Formula: C₂₉H₄₀O₃
• Molecular Weight: 436.635
• Mol file: 1262388-86-2.mol

Synonyms:(2R,3R)-3-ethyl-2-((R)-1-((1R,2R)-2-hydroxy-1,2-diphenylethoxy)heptyl)cyclohexanone

Chemical Property of (2R,3R)-3-ethyl-2-((R)-1-((1R,2R)-2-hydroxy-1,2-diphenylethoxy)heptyl)cyclohexanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R)-3-ethyl-2-((R)-1-((1R,2R)-2-hydroxy-1,2-diphenylethoxy)heptyl)cyclohexanone

There total 7 articles about (2R,3R)-3-ethyl-2-((R)-1-((1R,2R)-2-hydroxy-1,2-diphenylethoxy)heptyl)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

(4R,5R)-2-hexyl-4,5-diphenyl-1,3-dioxolane (1262388-76-0) + (R)-trimethyl(3-ethylcyclohex-1-enyloxy)silane (1262388-94-2) → (2R,3R)-3-ethyl-2-((R)-1-((1R,2R)-2-hydroxy-1,2-diphenylethoxy)heptyl)cyclohexanone (1262388-86-2)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at -78 ℃; for 4h; stereoselective reaction;

DOI:10.1016/j.tet.2010.10.048

Reference yield:

(4R,5R)-2-hexyl-4,5-diphenyl-1,3-dioxolane (1262388-76-0) + C2H5ZnOC6H8C2H5 → (2R,3R)-3-ethyl-2-((R)-1-((1R,2R)-2-hydroxy-1,2-diphenylethoxy)heptyl)cyclohexanone (1262388-86-2) + (2R,3R)-3-ethyl-2-(1-(2-hydroxy-1,2-diphenylethoxy)heptyl)cyclohexanone

Guidance literature:

With titanium tetrachloride; In hexane; dichloromethane; at -50 - 20 ℃; Overall yield = 70 mg; Inert atmosphere;

DOI:10.1016/j.tet.2010.10.048

Reference yield:

cyclohexenone (930-68-7) → (2R,3R)-3-ethyl-2-((R)-1-((1R,2R)-2-hydroxy-1,2-diphenylethoxy)heptyl)cyclohexanone (1262388-86-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: copper(II) bis(trifluoromethanesulfonate); (3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-(1-phenyl-ethyl)-amine / dichloromethane; hexane / -20 °C / Inert atmosphere; Schlenk technique

1.2: 0.5 h / -20 °C / Inert atmosphere; Schlenk technique

2.1: titanium tetrachloride / dichloromethane; hexane / -50 - 20 °C / Inert atmosphere

With titanium tetrachloride; copper(II) bis(trifluoromethanesulfonate); (3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-(1-phenyl-ethyl)-amine; In hexane; dichloromethane;

DOI:10.1016/j.tet.2010.10.048

upstream raw materials:

stilbene

cyclohexenone

(4R,5R)-2-hexyl-4,5-diphenyl-1,3-dioxolane

(R,R)-hydroxybenzoin

Downstream raw materials:

(2R,3R)-3-ethyl-2-((R)-1-hydroxyheptyl)cyclohexanone