2-<2-<4-<<5-<(2,5-dioxo-1-pyrrolidynyl)oxy>-1,5-dioxopentyl>amino>phenyl>-1-hydroxyethyl>-1-methylbenzene

Base Information

Chemical Name:2-<2-<4-<<5-<(2,5-dioxo-1-pyrrolidynyl)oxy>-1,5-dioxopentyl>amino>phenyl>-1-hydroxyethyl>-1-methylbenzene
CAS No.:134485-42-0
Molecular Formula:C₂₄H₂₆N₂O₆
Molecular Weight:438.48
Hs Code.:

Synonyms:2-<2-<4-<<5-<(2,5-dioxo-1-pyrrolidynyl)oxy>-1,5-dioxopentyl>amino>phenyl>-1-hydroxyethyl>-1-methylbenzene

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Chemical Property of 2-<2-<4-<<5-<(2,5-dioxo-1-pyrrolidynyl)oxy>-1,5-dioxopentyl>amino>phenyl>-1-hydroxyethyl>-1-methylbenzene

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Technology Process of 2-<2-<4-<<5-<(2,5-dioxo-1-pyrrolidynyl)oxy>-1,5-dioxopentyl>amino>phenyl>-1-hydroxyethyl>-1-methylbenzene

There total 9 articles about 2-<2-<4-<<5-<(2,5-dioxo-1-pyrrolidynyl)oxy>-1,5-dioxopentyl>amino>phenyl>-1-hydroxyethyl>-1-methylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 134485-56-6
2-<2-(4-aminophenyl)-1-hydroxyethyl>-1-methylbenzene

: 117746-42-6
5-[(2',5'-dioxo-1'-pyrrolidinyl)oxy]-5-oxopentanoyl chloride

: 134485-42-0
2-<2-<4-<<5-<(2,5-dioxo-1-pyrrolidynyl)oxy>-1,5-dioxopentyl>amino>phenyl>-1-hydroxyethyl>-1-methylbenzene

Guidance literature:: With triethylamine; In dichloromethane; for 0.5h;
DOI:10.1021/ja00014a039

Reference yield:

: 100-13-0
4-nitrostyrene

: 134485-42-0
2-<2-<4-<<5-<(2,5-dioxo-1-pyrrolidynyl)oxy>-1,5-dioxopentyl>amino>phenyl>-1-hydroxyethyl>-1-methylbenzene

Guidance literature:: Multi-step reaction with 8 steps

1: 50 percent / Pb(OAc)4, TFA / CH₂Cl₂ / 3 h / Ambient temperature

2: 60 percent / Rexyn 101 (H) cation-exchange resin, CaSO₄ / CH₂Cl₂ / 24 h / Ambient temperature

3: 95 percent / H₂ / 10percent Pd/C / methanol / 6 h / Ambient temperature

4: 80 percent / Et₃N / CH₂Cl₂ / 1 h

5: 40 percent / 4 M HCl / acetone / 24 h / Ambient temperature

6: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 2 h

7: 95 percent / H₂ / 10percent Pd/C / ethyl acetate / 4 h / 2585.7 Torr

8: 85 percent / Et₃N / CH₂Cl₂ / 0.5 h

With lead(IV) acetate; hydrogenchloride; calcium sulfate; n-butyllithium; Rexyn 101 (H) cation-exchange resin; hydrogen; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; acetone;
DOI:10.1021/ja00014a039

Reference yield:

: 1460-05-5
p-nitrophenylacetaldehyde

: 134485-42-0
2-<2-<4-<<5-<(2,5-dioxo-1-pyrrolidynyl)oxy>-1,5-dioxopentyl>amino>phenyl>-1-hydroxyethyl>-1-methylbenzene

Guidance literature:: Multi-step reaction with 7 steps

1: 60 percent / Rexyn 101 (H) cation-exchange resin, CaSO₄ / CH₂Cl₂ / 24 h / Ambient temperature

2: 95 percent / H₂ / 10percent Pd/C / methanol / 6 h / Ambient temperature

3: 80 percent / Et₃N / CH₂Cl₂ / 1 h

4: 40 percent / 4 M HCl / acetone / 24 h / Ambient temperature

5: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 2 h

6: 95 percent / H₂ / 10percent Pd/C / ethyl acetate / 4 h / 2585.7 Torr

7: 85 percent / Et₃N / CH₂Cl₂ / 0.5 h

With hydrogenchloride; calcium sulfate; n-butyllithium; Rexyn 101 (H) cation-exchange resin; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; acetone;
DOI:10.1021/ja00014a039